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PLA2R1 phospholipase A2 receptor 1 [ Homo sapiens (human) ]

Gene ID: 22925, updated on 1-Aug-2020

Summary

Official Symbol
PLA2R1provided by HGNC
Official Full Name
phospholipase A2 receptor 1provided by HGNC
Primary source
HGNC:HGNC:9042
See related
Ensembl:ENSG00000153246 MIM:604939
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLA2R; PLA2-R; PLA2IR; CLEC13C; PLA2G1R
Summary
This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Expression
Broad expression in thyroid (RPKM 11.6), kidney (RPKM 5.9) and 16 other tissues See more
Orthologs

Genomic context

See PLA2R1 in Genome Data Viewer
Location:
2q24.2
Exon count:
35
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (159932002..160062615, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (160788523..160919126, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene membrane associated ring-CH-type finger 7 Neighboring gene LY75-CD302 readthrough Neighboring gene CD302 molecule Neighboring gene lymphocyte antigen 75 Neighboring gene uncharacterized LOC105373717 Neighboring gene integrin subunit beta 6 Neighboring gene ITGB6-RBMS1 intergenic CAGE-defined low expression enhancer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association of serum bilirubin levels in Korean population.
NHGRI GWA Catalog
Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase binding IEA
Inferred from Electronic Annotation
more info
 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of arachidonic acid secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of phospholipase A2 activity ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidative stress-induced premature senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of arachidonic acid secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of glomerular visceral epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
replicative senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
secretory phospholipase A2 receptor
Names
180 kDa secretory phospholipase A2 receptor
C-type lectin domain family 13 member C
M-type receptor
phospholipase A2 receptor 1, 180kD
phospholipase A2 receptor 1, 180kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007267.2NP_001007268.1  secretory phospholipase A2 receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001007268.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein. It encodes a secreted isoform (2), which lacks a C-terminal transmembrane region found in isoform 1.
    Source sequence(s)
    AC080166, AI672072, AL598405, BC140823, BP351340, W15508
    Consensus CDS
    CCDS42767.1
    UniProtKB/Swiss-Prot
    Q13018
    Related
    ENSP00000376524.1, ENST00000392771.1
    Conserved Domains (5) summary
    smart00059
    Location:171219
    FN2; Fibronectin type 2 domain
    cd00037
    Location:242356
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:378502
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:43151
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:39119
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
  2. NM_001195641.2NP_001182570.1  secretory phospholipase A2 receptor isoform 3 precursor

    See identical proteins and their annotated locations for NP_001182570.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC080166, AC093873, BC144631, BP351340, U17033
    UniProtKB/Swiss-Prot
    Q13018
    UniProtKB/TrEMBL
    B7ZML4
    Conserved Domains (5) summary
    smart00059
    Location:171219
    FN2; Fibronectin type 2 domain
    cd00037
    Location:242356
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:378502
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:43151
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:39119
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
  3. NM_007366.5NP_031392.3  secretory phospholipase A2 receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_031392.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC080166, AC093873, BC140823, BP351340, U17033
    Consensus CDS
    CCDS33309.1
    UniProtKB/Swiss-Prot
    Q13018
    Related
    ENSP00000283243.7, ENST00000283243.13
    Conserved Domains (5) summary
    smart00059
    Location:171219
    FN2; Fibronectin type 2 domain
    cd00037
    Location:242356
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:378502
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:43151
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:39119
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    159932002..160062615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510820.3XP_011509122.1  secretory phospholipase A2 receptor isoform X1

    See identical proteins and their annotated locations for XP_011509122.1

    UniProtKB/Swiss-Prot
    Q13018
    Conserved Domains (5) summary
    smart00059
    Location:171219
    FN2; Fibronectin type 2 domain
    cd00037
    Location:242356
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:378502
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:43151
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:39119
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
  2. XM_005246392.4XP_005246449.1  secretory phospholipase A2 receptor isoform X1

    See identical proteins and their annotated locations for XP_005246449.1

    UniProtKB/Swiss-Prot
    Q13018
    Conserved Domains (5) summary
    smart00059
    Location:171219
    FN2; Fibronectin type 2 domain
    cd00037
    Location:242356
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:378502
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:43151
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:39119
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
  3. XM_017003598.1XP_016859087.1  secretory phospholipase A2 receptor isoform X1

    UniProtKB/Swiss-Prot
    Q13018
    Conserved Domains (5) summary
    smart00059
    Location:171219
    FN2; Fibronectin type 2 domain
    cd00037
    Location:242356
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:378502
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:43151
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:39119
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
  4. XM_017003602.1XP_016859091.1  secretory phospholipase A2 receptor isoform X5

    Conserved Domains (1) summary
    smart00034
    Location:129251
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
  5. XM_017003600.2XP_016859089.1  secretory phospholipase A2 receptor isoform X3

    Conserved Domains (1) summary
    smart00034
    Location:197319
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
  6. XM_017003599.1XP_016859088.1  secretory phospholipase A2 receptor isoform X2

  7. XM_017003601.2XP_016859090.1  secretory phospholipase A2 receptor isoform X4

RNA

  1. XR_922892.3 RNA Sequence

  2. XR_001738672.2 RNA Sequence

  3. XR_001738671.2 RNA Sequence

  4. XR_001738673.1 RNA Sequence

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