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Prkcz protein kinase C, zeta [ Mus musculus (house mouse) ]

Gene ID: 18762, updated on 6-Jun-2024

Summary

Official Symbol
Prkczprovided by MGI
Official Full Name
protein kinase C, zetaprovided by MGI
Primary source
MGI:MGI:97602
See related
Ensembl:ENSMUSG00000029053 AllianceGenome:MGI:97602
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkcz; zetaPKC; aPKCzeta; nPKC-zeta
Summary
Enables protein serine/threonine kinase activity. Involved in positive regulation of T-helper 2 cell differentiation and positive regulation of cytokine production. Acts upstream of or within several processes, including neuron projection extension; protein localization to plasma membrane; and protein phosphorylation. Located in several cellular components, including axon hillock; myelin sheath abaxonal region; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PRKCZ (protein kinase C zeta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 34.2), cerebellum adult (RPKM 31.5) and 19 other tissues See more
Orthologs
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Genomic context

See Prkcz in Genome Data Viewer
Location:
4 E2; 4 86.17 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155344579..155445856, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155260118..155361428, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6296 Neighboring gene predicted gene, 33187 Neighboring gene Fanconi anemia core complex associated protein 20 Neighboring gene STARR-seq mESC enhancer starr_12256 Neighboring gene RIKEN cDNA 5830444B04 gene Neighboring gene gamma-aminobutyric acid (GABA) A receptor, subunit delta Neighboring gene cilia and flagella associated protein 74

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables diacylglycerol-dependent serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase binding ISO
Inferred from Sequence Orthology
more info
 
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in long-term memory ISO
Inferred from Sequence Orthology
more info
 
involved_in long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane hyperpolarization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within microtubule cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron projection extension IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T-helper 2 cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T-helper 2 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-13 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-5 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle transport along microtubule ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in apical cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon hillock IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule organizing center IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in myelin sheath abaxonal region IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein kinase C zeta type
Names
atypical protein kinase C
protein kinase C zeta subspecies
NP_001034168.1
NP_001342107.1
NP_001411727.1
NP_001411728.1
NP_001411729.1
NP_001411730.1
NP_001411731.1
NP_001411732.1
NP_001411733.1
NP_032886.2
XP_006538719.1
XP_017175531.1
XP_030109177.1
XP_036019727.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039079.3NP_001034168.1  protein kinase C zeta type isoform b

    See identical proteins and their annotated locations for NP_001034168.1

    Status: VALIDATED

    Source sequence(s)
    AL670227, AL670413
    Consensus CDS
    CCDS19027.1
    UniProtKB/TrEMBL
    Q3V341
    Related
    ENSMUSP00000099467.5, ENSMUST00000103178.11
    Conserved Domains (1) summary
    cl21453
    Location:53409
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001355178.2NP_001342107.1  protein kinase C zeta type isoform c

    Status: VALIDATED

    Source sequence(s)
    AL670227, AL670413
    UniProtKB/TrEMBL
    A4QPC7
    Conserved Domains (2) summary
    pfam00130
    Location:2373
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:128484
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001424798.1NP_001411727.1  protein kinase C zeta type isoform d

    Status: VALIDATED

    Source sequence(s)
    AL670227, AL670413
    UniProtKB/TrEMBL
    A4QPC7
  4. NM_001424799.1NP_001411728.1  protein kinase C zeta type isoform e

    Status: VALIDATED

    Source sequence(s)
    AL670227, AL670413
    UniProtKB/TrEMBL
    A4QPC7
  5. NM_001424800.1NP_001411729.1  protein kinase C zeta type isoform f

    Status: VALIDATED

    Source sequence(s)
    AL670227, AL670413
    UniProtKB/TrEMBL
    A4QPC7
  6. NM_001424801.1NP_001411730.1  protein kinase C zeta type isoform g

    Status: VALIDATED

    Source sequence(s)
    AL670227, AL670413
  7. NM_001424802.1NP_001411731.1  protein kinase C zeta type isoform h

    Status: VALIDATED

    Source sequence(s)
    AL670227, AL670413
  8. NM_001424803.1NP_001411732.1  protein kinase C zeta type isoform i

    Status: VALIDATED

    Source sequence(s)
    AL670227, AL670413
  9. NM_001424804.1NP_001411733.1  protein kinase C zeta type isoform j

    Status: VALIDATED

    Source sequence(s)
    AL670227, AL670413
  10. NM_008860.4NP_032886.2  protein kinase C zeta type isoform a

    See identical proteins and their annotated locations for NP_032886.2

    Status: VALIDATED

    Source sequence(s)
    AL670227, AL670413
    Consensus CDS
    CCDS19026.1
    UniProtKB/Swiss-Prot
    A2AD76, Q02956, Q3UHM5, Q7TST7
    UniProtKB/TrEMBL
    A4QPC7
    Related
    ENSMUSP00000030922.8, ENSMUST00000030922.15
    Conserved Domains (4) summary
    cd06404
    Location:1698
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    smart00220
    Location:252518
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00130
    Location:131183
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:236592
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_188944.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL670227, AL670413

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    155344579..155445856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538656.4XP_006538719.1  protein kinase C zeta type isoform X2

    See identical proteins and their annotated locations for XP_006538719.1

    UniProtKB/TrEMBL
    Q3V341
    Conserved Domains (1) summary
    cl21453
    Location:53409
    PKc_like; Protein Kinases, catalytic domain
  2. XM_036163834.1XP_036019727.1  protein kinase C zeta type isoform X2

    UniProtKB/TrEMBL
    Q3V341
    Conserved Domains (1) summary
    cl21453
    Location:53409
    PKc_like; Protein Kinases, catalytic domain
  3. XM_030253317.1XP_030109177.1  protein kinase C zeta type isoform X2

    UniProtKB/TrEMBL
    Q3V341
    Conserved Domains (1) summary
    cl21453
    Location:53409
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017320042.3XP_017175531.1  protein kinase C zeta type isoform X2

    UniProtKB/TrEMBL
    Q3V341
    Conserved Domains (1) summary
    cl21453
    Location:53409
    PKc_like; Protein Kinases, catalytic domain