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PRKCZ protein kinase C zeta [ Homo sapiens (human) ]

Gene ID: 5590, updated on 1-Jun-2020

Summary

Official Symbol
PRKCZprovided by HGNC
Official Full Name
protein kinase C zetaprovided by HGNC
Primary source
HGNC:HGNC:9412
See related
Ensembl:ENSG00000067606 MIM:176982
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PKC2; PKC-ZETA
Summary
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 11.4), placenta (RPKM 8.8) and 22 other tissues See more
Orthologs

Genomic context

See PRKCZ in Genome Data Viewer
Location:
1p36.33
Exon count:
29
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (2050411..2185399)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1981909..2116834)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378590 Neighboring gene uncharacterized LOC105378591 Neighboring gene PRKCZ antisense RNA 1 Neighboring gene uncharacterized LOC112268219 Neighboring gene FA core complex associated protein 20 Neighboring gene uncharacterized LOC105378593

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896 PubMed
env Down modulation of the interaction between HIV-1 gp120 and CD4 by TPA is blocked by protein kinase C (PKC) inhibitors, suggesting PKC may play an important role in HIV-1 infection PubMed
env c-FLIPL inhibits Bax activation via modulating PKC expression at the transcriptional level involving AP-2 during gp120 treatment PubMed
env Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax PubMed
env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
env HIV-1 gp120 increases the levels of calcium-dependent and -independent PKC isozymes; the most striking change is observed in PKC-zeta isozyme levels PubMed
env A specific interaction between CD4 and HIV-1 gp120 is required for phosphorylation of CD4, which could involve protein kinase C PubMed
env IL-16 induces rapid translocation of PKC from the cytosol to the membrane in CD4+ cells; PKC inhibitors completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibody binding to CD4 PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160-induced AP-1 complex formation is dependent upon protein tyrosine phosphorylation and is abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blockers or cyclosporine A PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to cytoplasmic domain residues 828-848 of HIV-1 gp41 inhibits pKC-catalysed phosphorylation of a protein substrate PubMed
env A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC PubMed
Pr55(Gag) gag The phosphorylation of HIV-1 Gag by PRKCI regulates HIV-1 Vpr incorporation into virions and HIV-1 replication in macrophages PubMed
gag Immunoprecipation analysis demonstrates that PRKCZ binds HIV-1 Gag and phosphorylates Gag at position serine 487 in the p6 domain of Gag PubMed
gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with PRKCZ PubMed
Tat tat HIV-1 Tat increases CXCL12-induced internalization of CXCR4, and the Tat-mediated CXCR4 internalization requires activity of protein kinase C (zeta) PubMed
tat Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT PubMed
tat Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth PubMed
tat Protein kinase C phosphorylates HIV-1 Tat on serine residue 46 PubMed
tat HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1 PubMed
Vpr vpr The phosphorylation of HIV-1 Gag at Ser487 by PRKCZ regulates HIV-1 Vpr incorporation into virions and HIV-1 replication in macrophages PubMed
matrix gag Protein kinase C (PKC) phosphorylates HIV-1 Matrix on serine residue 111 resulting in a shift in localization of Matrix from the cytosol to the cellular membrane, suggesting a myristoyl-protein switch regulated by PKC phosphorylation PubMed
retropepsin gag-pol Phosphorylation of human recombinant vimentin by PKC inhibits the proteolytic processing of the vimentin head domain by HIV-1 protease PubMed
reverse transcriptase gag-pol HIV-1 RT heterodimer expressed in bacteria can be phosphorylated in vitro by several purified mammalian protein kinases including auto-activated protein kinase (PK), CKII, cytosolic protamine kinase (CPK), myelin basic protein kinase 1 (MBPK1), and PRKC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
14-3-3 protein binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
insulin receptor substrate binding IC
Inferred by Curator
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase binding IEA
Inferred from Electronic Annotation
more info
 
potassium channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of phospholipase D activity IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase B activity IEA
Inferred from Electronic Annotation
more info
 
cell migration IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
establishment of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-term memory IEA
Inferred from Electronic Annotation
more info
 
long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane depolarization IEA
Inferred from Electronic Annotation
more info
 
membrane hyperpolarization IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection extension IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of T-helper 2 cell cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of T-helper 2 cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-10 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-13 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-4 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-5 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase C signaling IEA
Inferred from Electronic Annotation
more info
 
protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
 
vesicle transport along microtubule IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
apical cortex IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
axon hillock IEA
Inferred from Electronic Annotation
more info
 
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
cell junction TAS
Traceable Author Statement
more info
 
cell leading edge IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
myelin sheath abaxonal region IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
stress fiber IEA
Inferred from Electronic Annotation
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein kinase C zeta type
Names
nPKC-zeta
NP_001028753.1
NP_001028754.1
NP_001229803.1
NP_001337732.1
NP_001337733.1
NP_001337734.1
NP_001337735.1
NP_002735.3
XP_011540075.1
XP_011540076.1
XP_011540077.1
XP_011540078.1
XP_016857278.1
XP_016857279.1
XP_016857281.1
XP_016857282.1
XP_016857286.1
XP_016857289.1
XP_016857290.1
XP_016857291.1
XP_016857292.1
XP_024304158.1
XP_024304159.1
XP_024304164.1
XP_024304165.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029616.1 RefSeqGene

    Range
    4942..139926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001033581.2NP_001028753.1  protein kinase C zeta type isoform 2

    See identical proteins and their annotated locations for NP_001028753.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AI186591, BC008058, CB152283, DA392984
    Consensus CDS
    CCDS41229.1
    UniProtKB/Swiss-Prot
    Q05513
    Related
    ENSP00000383712.2, ENST00000400921.6
    Conserved Domains (1) summary
    cl21453
    Location:53409
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001033582.2NP_001028754.1  protein kinase C zeta type isoform 2

    See identical proteins and their annotated locations for NP_001028754.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AI186591, AL542576, AU134793, BC008058
    Consensus CDS
    CCDS41229.1
    UniProtKB/Swiss-Prot
    Q05513
    Conserved Domains (1) summary
    cl21453
    Location:53409
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001242874.2NP_001229803.1  protein kinase C zeta type isoform 3

    See identical proteins and their annotated locations for NP_001229803.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AI186591, AK294782, AL590822, BC008058, DC312466
    Consensus CDS
    CCDS55563.1
    UniProtKB/Swiss-Prot
    Q05513
    Related
    ENSP00000426412.1, ENST00000461106.6
    Conserved Domains (2) summary
    pfam00130
    Location:2777
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:132488
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001350803.1NP_001337732.1  protein kinase C zeta type isoform 4

    Status: REVIEWED

    Source sequence(s)
    AI186591, BC008058, BQ084132, CB152283, DA392984
    Conserved Domains (1) summary
    cl21453
    Location:53417
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001350804.1NP_001337733.1  protein kinase C zeta type isoform 4

    Status: REVIEWED

    Source sequence(s)
    AI186591, AL645703, BC008058, BQ084132, CB152283, DA392984
    Conserved Domains (1) summary
    cl21453
    Location:53417
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001350805.1NP_001337734.1  protein kinase C zeta type isoform 5

    Status: REVIEWED

    Source sequence(s)
    AI186591, AL590822, BC008058, DC326590, DC328654
    Conserved Domains (1) summary
    cl21453
    Location:1355
    PKc_like; Protein Kinases, catalytic domain
  7. NM_001350806.1NP_001337735.1  protein kinase C zeta type isoform 5

    Status: REVIEWED

    Source sequence(s)
    AI186591, AL590822, BC008058, DA392984, DC314278
    Conserved Domains (1) summary
    cl21453
    Location:1355
    PKc_like; Protein Kinases, catalytic domain
  8. NM_002744.6NP_002735.3  protein kinase C zeta type isoform 1

    See identical proteins and their annotated locations for NP_002735.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL391845, BC008058, BC014270
    Consensus CDS
    CCDS37.1
    UniProtKB/Swiss-Prot
    Q05513
    Related
    ENSP00000367830.3, ENST00000378567.8
    Conserved Domains (3) summary
    cd06404
    Location:1698
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05617
    Location:236592
    STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    pfam00130
    Location:131181
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RNA

  1. NR_146911.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AI186591, BC008058, CB152283, DA392984, HY218327

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    2050411..2185399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001790.1XP_016857279.1  protein kinase C zeta type isoform X2

  2. XM_017001789.1XP_016857278.1  protein kinase C zeta type isoform X1

  3. XM_011541773.1XP_011540075.1  protein kinase C zeta type isoform X3

    Conserved Domains (4) summary
    cd06404
    Location:1698
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    smart00220
    Location:252518
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00130
    Location:131181
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:236529
    PKc_like; Protein Kinases, catalytic domain
  4. XM_011541775.3XP_011540077.1  protein kinase C zeta type isoform X8

    Conserved Domains (3) summary
    cd06404
    Location:1698
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    pfam00130
    Location:131181
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:236325
    PKc_like; Protein Kinases, catalytic domain
  5. XM_017001803.2XP_016857292.1  protein kinase C zeta type isoform X14

  6. XM_017001802.1XP_016857291.1  protein kinase C zeta type isoform X13

  7. XM_024448390.1XP_024304158.1  protein kinase C zeta type isoform X5

    Conserved Domains (1) summary
    cl21453
    Location:187394
    PKc_like; Protein Kinases, catalytic domain
  8. XM_017001792.1XP_016857281.1  protein kinase C zeta type isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:53354
    PKc_like; Protein Kinases, catalytic domain
  9. XM_011541776.1XP_011540078.1  protein kinase C zeta type isoform X9

    See identical proteins and their annotated locations for XP_011540078.1

    Conserved Domains (1) summary
    cl21453
    Location:53346
    PKc_like; Protein Kinases, catalytic domain
  10. XM_011541774.1XP_011540076.1  protein kinase C zeta type isoform X4

    Conserved Domains (3) summary
    smart00220
    Location:148414
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00130
    Location:2777
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:132425
    PKc_like; Protein Kinases, catalytic domain
  11. XM_024448391.1XP_024304159.1  protein kinase C zeta type isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:53354
    PKc_like; Protein Kinases, catalytic domain
  12. XM_024448396.1XP_024304164.1  protein kinase C zeta type isoform X9

    Conserved Domains (1) summary
    cl21453
    Location:53346
    PKc_like; Protein Kinases, catalytic domain
  13. XM_017001793.1XP_016857282.1  protein kinase C zeta type isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:53354
    PKc_like; Protein Kinases, catalytic domain
  14. XM_017001801.1XP_016857290.1  protein kinase C zeta type isoform X11

    Related
    ENST00000479263.5
    Conserved Domains (1) summary
    cl21453
    Location:49405
    PKc_like; Protein Kinases, catalytic domain
  15. XM_017001797.1XP_016857286.1  protein kinase C zeta type isoform X7

  16. XM_017001800.1XP_016857289.1  protein kinase C zeta type isoform X10

    Conserved Domains (2) summary
    smart00220
    Location:65331
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:49342
    PKc_like; Protein Kinases, catalytic domain
  17. XM_024448397.1XP_024304165.1  protein kinase C zeta type isoform X12

    Conserved Domains (1) summary
    cl21453
    Location:1300
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_002957130.1 RNA Sequence

  2. XR_002957131.1 RNA Sequence

  3. XR_001737315.2 RNA Sequence

    Related
    ENST00000478770.6
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