U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prkcq protein kinase C, theta [ Mus musculus (house mouse) ]

Gene ID: 18761, updated on 8-Feb-2024

Summary

Official Symbol
Prkcqprovided by MGI
Official Full Name
protein kinase C, thetaprovided by MGI
Primary source
MGI:MGI:97601
See related
Ensembl:ENSMUSG00000026778 AllianceGenome:MGI:97601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkcq; PKC-0; PKCtheta; PKC-theta; A130035A12Rik
Summary
Enables protein kinase C activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of cytokine production; and regulation of cell-cell adhesion. Acts upstream of or within several processes, including positive regulation of T cell proliferation; positive regulation of interleukin-2 production; and protein phosphorylation. Located in cytoplasm and immunological synapse. Is expressed in several structures, including adipose tissue; genitourinary system; gut; limb; and nervous system. Used to study retinal detachment. Orthologous to human PRKCQ (protein kinase C theta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 34.4), thymus adult (RPKM 13.0) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Prkcq in Genome Data Viewer
Location:
2 A1; 2 8.42 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (11176922..11306033)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (11171905..11301226)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03659 Neighboring gene STARR-seq mESC enhancer starr_03660 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene zinc finger and BTB domain containing 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03661 Neighboring gene STARR-positive B cell enhancer ABC_E2601 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:11116705-11116814 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:11126023-11126241 Neighboring gene STARR-seq mESC enhancer starr_03662 Neighboring gene STARR-seq mESC enhancer starr_03663 Neighboring gene STARR-positive B cell enhancer mm9_chr2:11210120-11210420 Neighboring gene STARR-positive B cell enhancer ABC_E10081 Neighboring gene RIKEN cDNA 8030442B05 gene Neighboring gene predicted gene, 38171 Neighboring gene predicted gene 13293

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (2) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables diacylglycerol-dependent serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables diacylglycerol-dependent serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of CD4-positive, alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of T cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity ISA
Inferred from Sequence Alignment
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T-helper 17 type immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T-helper 2 cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in aggresome ISO
Inferred from Sequence Orthology
more info
 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein kinase C theta type
Names
PKC theta
nPKC-theta
NP_001405286.1
NP_001405287.1
NP_001405288.1
NP_032885.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418357.1NP_001405286.1  protein kinase C theta type isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL928715, AL929020
    UniProtKB/TrEMBL
    F8WGT6
  2. NM_001418358.1NP_001405287.1  protein kinase C theta type isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL928715, AL929020
    UniProtKB/TrEMBL
    F8WGT6
  3. NM_001418359.1NP_001405288.1  protein kinase C theta type isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL929020
    UniProtKB/TrEMBL
    Q920N8
    Related
    ENSMUST00000195628.2
  4. NM_008859.3NP_032885.1  protein kinase C theta type isoform 1

    See identical proteins and their annotated locations for NP_032885.1

    Status: VALIDATED

    Source sequence(s)
    AL928715, AL929020
    Consensus CDS
    CCDS15682.1
    UniProtKB/Swiss-Prot
    Q02111
    UniProtKB/TrEMBL
    A6H667, F8WGT6
    Related
    ENSMUSP00000028118.4, ENSMUST00000028118.9
    Conserved Domains (3) summary
    smart00220
    Location:380634
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05619
    Location:374704
    STKc_nPKC_theta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta
    pfam00130
    Location:232284
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    11176922..11306033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178075.2: Suppressed sequence

    Description
    NM_178075.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.