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Pdpk1 3-phosphoinositide dependent protein kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 18607, updated on 27-Nov-2024

Summary

Official Symbol
Pdpk1provided by MGI
Official Full Name
3-phosphoinositide dependent protein kinase 1provided by MGI
Primary source
MGI:MGI:1338068
See related
Ensembl:ENSMUSG00000024122 AllianceGenome:MGI:1338068
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pdk1
Summary
Enables 3-phosphoinositide-dependent protein kinase activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; negative regulation of cardiac muscle cell apoptotic process; and type B pancreatic cell development. Acts upstream of or within hyperosmotic response. Located in cytoplasmic vesicle and postsynaptic density. Is expressed in several structures, including central nervous system; early conceptus; gonad; hemolymphoid system gland; and retina. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including PDPK1 (3-phosphoinositide dependent protein kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Note: Pdk1 (Gene ID: 228026) and Pdpk1 (Gene ID: 18607) share the Pdk1 symbol/alias in common. Pdk1 is a widely used alternative name for 3-phosphoinositide dependent protein kinase 1 (Pdpk1), which can be confused with the official symbol for pyruvate dehydrogenase kinase, isoenzyme 1 (Pdk1). [03 Apr 2019]
Expression
Ubiquitous expression in testis adult (RPKM 17.0), thymus adult (RPKM 9.0) and 28 other tissues See more
Orthologs
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Genomic context

See Pdpk1 in Genome Data Viewer
Location:
17 A3.3; 17 12.23 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24292654..24370957, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24073680..24155619, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene serine protease 27 Neighboring gene potassium channel tetramerisation domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E8657 Neighboring gene STARR-seq mESC enhancer starr_42072 Neighboring gene STARR-seq mESC enhancer starr_42074 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:24274163-24274452 Neighboring gene STARR-positive B cell enhancer ABC_E1935 Neighboring gene predicted gene, 33409 Neighboring gene STARR-seq mESC enhancer starr_42075 Neighboring gene amidohydrolase domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E8658 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 3-phosphoinositide-dependent protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 3-phosphoinositide-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to epidermal growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hyperosmotic response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in type B pancreatic cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
3-phosphoinositide-dependent protein kinase 1
Names
Pkb kinase
NP_001074242.1
NP_001273591.1
NP_035192.2
XP_017172809.1
XP_017172810.1
XP_017172811.1
XP_017172813.1
XP_017172814.1
XP_017172815.1
XP_030105434.1
XP_030105435.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080773.2NP_001074242.1  3-phosphoinositide-dependent protein kinase 1 isoform B

    See identical proteins and their annotated locations for NP_001074242.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 3' region, compared to variant 1. The resulting isoform (B) is shorter and has a distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AK162677, BQ175596, BY257456
    Consensus CDS
    CCDS37483.1
    UniProtKB/TrEMBL
    Q3TRL2, Q3UGN6, Q3UHZ0
    Related
    ENSMUSP00000111070.2, ENSMUST00000115411.8
    Conserved Domains (3) summary
    smart00220
    Location:85345
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01262
    Location:444521
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:83345
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
  2. NM_001286662.1NP_001273591.1  3-phosphoinositide-dependent protein kinase 1 isoform C

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon, which results in translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (C) has a shorter N-terminus, compared to isoform A.
    Source sequence(s)
    AK147835, AK149162, CJ046953, CT010502
    Consensus CDS
    CCDS70767.1
    UniProtKB/TrEMBL
    F2Z3X6, Q8K3L3
    Related
    ENSMUSP00000061942.7, ENSMUST00000052462.13
    Conserved Domains (2) summary
    cd01262
    Location:417523
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:56318
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
  3. NM_011062.4NP_035192.2  3-phosphoinositide-dependent protein kinase 1 isoform A

    See identical proteins and their annotated locations for NP_035192.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (A).
    Source sequence(s)
    AK147149, AK147835, BQ175596, BY257456, CT010502
    Consensus CDS
    CCDS28474.1
    UniProtKB/Swiss-Prot
    A6H6U3, Q9R1D8, Q9R215, Q9Z2A0
    UniProtKB/TrEMBL
    Q3UHZ0
    Related
    ENSMUSP00000099991.4, ENSMUST00000102927.10
    Conserved Domains (3) summary
    smart00220
    Location:85345
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01262
    Location:444550
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:83345
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24292654..24370957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317324.3XP_017172813.1  3-phosphoinositide-dependent protein kinase 1 isoform X2

    Conserved Domains (2) summary
    cd01262
    Location:283389
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cl21453
    Location:47184
    PKc_like; Protein Kinases, catalytic domain
  2. XM_030249574.2XP_030105434.1  3-phosphoinositide-dependent protein kinase 1 isoform X3

    Conserved Domains (2) summary
    cd01262
    Location:225331
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cl21453
    Location:1126
    PKc_like; Protein Kinases, catalytic domain
  3. XM_017317326.3XP_017172815.1  3-phosphoinositide-dependent protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    F2Z3X6, Q8K3L3
    Conserved Domains (2) summary
    cd01262
    Location:417523
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:56318
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
  4. XM_017317325.3XP_017172814.1  3-phosphoinositide-dependent protein kinase 1 isoform X2

    Conserved Domains (2) summary
    cd01262
    Location:283389
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cl21453
    Location:47184
    PKc_like; Protein Kinases, catalytic domain
  5. XM_030249575.2XP_030105435.1  3-phosphoinositide-dependent protein kinase 1 isoform X3

    Conserved Domains (2) summary
    cd01262
    Location:225331
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cl21453
    Location:1126
    PKc_like; Protein Kinases, catalytic domain
  6. XM_017317321.3XP_017172810.1  3-phosphoinositide-dependent protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    F2Z3X6, Q8K3L3
    Conserved Domains (2) summary
    cd01262
    Location:417523
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:56318
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
  7. XM_017317320.3XP_017172809.1  3-phosphoinositide-dependent protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    F2Z3X6, Q8K3L3
    Conserved Domains (2) summary
    cd01262
    Location:417523
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:56318
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
  8. XM_017317322.1XP_017172811.1  3-phosphoinositide-dependent protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    F2Z3X6, Q8K3L3
    Conserved Domains (2) summary
    cd01262
    Location:417523
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:56318
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1