Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Enpp2provided by MGI
Official Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 2provided by MGI
Primary source: MGI:MGI:1321390
See related: Ensembl:ENSMUSG00000022425 AllianceGenome:MGI:1321390
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ATX; Npps2; Pdnp2; E-NPP 2; lysoPLD; PD-Ialpha
Summary: This gene encodes a member of the phosphodiesterase and nucleotide pyrophosphatase family of bifunctional enzymes that hydrolize phosphodiester bonds of various nucleotides. The encoded protein undergoes proteolytic processing to generate a mature protein with lysophospholipase D activity, catalyzing the cleavage of the choline group from lysophosphatidylcholine to produce lysophosphatidic acid. This gene is expressed in numerous tissues and participates in neural development, obesity, inflammation and oncogenesis. A complete lack of the encoded protein in mice results in aberrant vascular and neuronal development leading to embryonic lethality. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2015]
Expression: Biased expression in cerebellum adult (RPKM 54.8), genital fat pad adult (RPKM 28.3) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 21.6 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (54702297..54816284, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (54838901..54952789, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dysregulated autotaxin expression by T cells in multiple sclerosis.
Title: Dysregulated autotaxin expression by T cells in multiple sclerosis.
Autotaxin in encephalitogenic CD4 T cells as a therapeutic target for multiple sclerosis.
Title: Autotaxin in encephalitogenic CD4 T cells as a therapeutic target for multiple sclerosis.
Autotaxin-lysophosphatidic acid receptor 5 axis evokes endothelial dysfunction via reactive oxygen species signaling.
Title: Autotaxin-lysophosphatidic acid receptor 5 axis evokes endothelial dysfunction via reactive oxygen species signaling.
The autotaxin-LPA axis promotes membrane trafficking and secretion in yolk sac visceral endoderm cells.
Title: The autotaxin-LPA axis promotes membrane trafficking and secretion in yolk sac visceral endoderm cells.
E2F7 drives autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not in human carcinomas.
Title: E2F7 drives autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not in human carcinomas.
Autotaxin (ATX) inhibits autophagy leading to exaggerated disruption of intestinal epithelial barrier in colitis.
Title: Autotaxin (ATX) inhibits autophagy leading to exaggerated disruption of intestinal epithelial barrier in colitis.
Endothelial Specific Deletion of Autotaxin Improves Stroke Outcomes.
Title: Endothelial Specific Deletion of Autotaxin Improves Stroke Outcomes.
Hepatocyte-Secreted Autotaxin Exacerbates Nonalcoholic Fatty Liver Disease Through Autocrine Inhibition of the PPARalpha/FGF21 Axis.
Title: Hepatocyte-Secreted Autotaxin Exacerbates Nonalcoholic Fatty Liver Disease Through Autocrine Inhibition of the PPARα/FGF21 Axis.
Endothelial ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) Increases Atherosclerosis in Female and Male Mice.
Title: Endothelial ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) Increases Atherosclerosis in Female and Male Mice.
Atx regulates skeletal muscle regeneration via LPAR1 and promotes hypertrophy.
Title: Atx regulates skeletal muscle regeneration via LPAR1 and promotes hypertrophy.

Submit: New GeneRIF Correction See all GeneRIFs (68)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Enpp2 (e-PCR), detects polymorphism
- UniSTS:472849

NoName (e-PCR)
- UniSTS:548456

D15Mit230 (e-PCR), detects polymorphism
- UniSTS:127602

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alkylglycerophosphoethanolamine phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkylglycerophosphoethanolamine phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables alkylglycerophosphoethanolamine phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables dinucleotide phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables lysophospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables lysophospholipase activity	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables phosphodiesterase I activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphodiesterase I activity	ISO Inferred from Sequence Orthology more info
enables phosphodiesterase I activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables phospholipase D activity	IEA Inferred from Electronic Annotation more info
enables polysaccharide binding	IEA Inferred from Electronic Annotation more info
enables scavenger receptor activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in estrous cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylcholine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylcholine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in sphingolipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in sphingolipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: autotaxin; ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Names: extracellular lysophospholipase D; phosphodiesterase I/nucleotide pyrophosphatase 2

NP_001129549.1

EC 3.1.4.39

EC 3.1.4.4

NP_001272923.1

EC 3.1.4.39

EC 3.1.4.4

NP_001272924.1

EC 3.1.4.39

EC 3.1.4.4

NP_001398580.1

EC 3.1.4.39

EC 3.1.4.4

NP_001398581.1

EC 3.1.4.39

EC 3.1.4.4

NP_001398582.1

EC 3.1.4.39

EC 3.1.4.4

NP_001398583.1

EC 3.1.4.39

EC 3.1.4.4

NP_001398584.1

EC 3.1.4.39

EC 3.1.4.4

NP_001398585.1

EC 3.1.4.39

EC 3.1.4.4

NP_001398586.1

EC 3.1.4.39

EC 3.1.4.4

NP_001398587.1

EC 3.1.4.39

EC 3.1.4.4

NP_056559.2

EC 3.1.4.39

EC 3.1.4.4

XP_017171994.1

EC 3.1.4.39

EC 3.1.4.4

XP_036015136.1

EC 3.1.4.39

EC 3.1.4.4

XP_036015137.1

EC 3.1.4.39

EC 3.1.4.4

XP_036015138.1

EC 3.1.4.39

EC 3.1.4.4

XP_036015139.1

EC 3.1.4.39

EC 3.1.4.4

XP_036015140.1

EC 3.1.4.39

EC 3.1.4.4

XP_036015142.1

EC 3.1.4.39

EC 3.1.4.4

XP_036015143.1

EC 3.1.4.39

EC 3.1.4.4

XP_036015144.1

EC 3.1.4.39

EC 3.1.4.4

XP_036015145.1

EC 3.1.4.39

EC 3.1.4.4

XP_036015147.1

EC 3.1.4.39

EC 3.1.4.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136077.3 → NP_001129549.1 autotaxin isoform 1

See identical proteins and their annotated locations for NP_001129549.1

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as alpha) represents the longest transcript and encodes the longest isoform (1). This isoform (1) may undergo proteolytic processing similar to isoform 2.

Source sequence(s)

AK163881, BY123373, CD741437, EU131009

Consensus CDS

CCDS49607.1

UniProtKB/Swiss-Prot

Q9R1E6

Related

ENSMUSP00000128941.2, ENSMUST00000171545.9

Conserved Domains (4) summary

smart00201
Location:56 → 97

SO; Somatomedin B -like domains

smart00477
Location:666 → 896

NUC; DNA/RNA non-specific endonuclease

pfam01663
Location:165 → 529

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cd16018
Location:163 → 569

Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
NM_001285994.2 → NP_001272923.1 autotaxin isoform 3

See identical proteins and their annotated locations for NP_001272923.1

Status: REVIEWED

Description

Transcript Variant: This variant (3, also known as gamma) lacks an in-frame exon and contains an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1. This isoform (3) may undergo proteolytic processing similar to isoform 2.

Source sequence(s)

AK163881, BY123373, CD741437, EU131010

Consensus CDS

CCDS70628.1

UniProtKB/Swiss-Prot

Q9R1E6

Related

ENSMUSP00000132640.3, ENSMUST00000167541.3

Conserved Domains (4) summary

smart00201
Location:56 → 97

SO; Somatomedin B -like domains

smart00477
Location:639 → 869

NUC; DNA/RNA non-specific endonuclease

pfam01663
Location:165 → 477

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cd16018
Location:163 → 517

Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
NM_001285995.2 → NP_001272924.1 autotaxin isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4, also known as epsilon) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1. This isoform (4) may undergo proteolytic processing similar to isoform 2.

Source sequence(s)

AK163881, BY123373, CD741437, EU131009

Consensus CDS

CCDS70629.1

UniProtKB/TrEMBL

G3UXY9

Related

ENSMUSP00000133877.2, ENSMUST00000173516.8

Conserved Domains (4) summary

smart00201
Location:56 → 97

SO; Somatomedin B -like domains

smart00477
Location:662 → 892

NUC; DNA/RNA non-specific endonuclease

pfam01663
Location:165 → 529

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cd16018
Location:163 → 569

Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
NM_001411651.1 → NP_001398580.1 autotaxin isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate in-frame splice site, lacks an in-frame exon, and contains an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (5) is shorter, compared to isoform 1. This isoform (5) may undergo proteolytic processing similar to isoform 2.

Source sequence(s)

AC123644
NM_001411652.1 → NP_001398581.1 autotaxin isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6) uses an alternate in-frame splice site and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (6) is shorter, compared to isoform 1. This isoform (6) may undergo proteolytic processing similar to isoform 2.

Source sequence(s)

AC123644
NM_001411653.1 → NP_001398582.1 autotaxin isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks an in-frame exon and lacks a frame-shifting exon in the central coding region, compared to variant 1. The encoded isoform (7) is shorter and has a distinct C-terminus, compared to isoform 1. This isoform (7) may undergo proteolytic processing similar to isoform 2.

Source sequence(s)

AC123644
NM_001411654.1 → NP_001398583.1 autotaxin isoform 8

Status: REVIEWED

Description

Transcript Variant: This variant (8) uses an alternate in-frame splice site, lacks an in-frame exon, and lacks a frame-shifting exon in the central coding region, compared to variant 1. The encoded isoform (8) is shorter and has a distinct C-terminus, compared to isoform 1. This isoform (8) may undergo proteolytic processing similar to isoform 2.

Source sequence(s)

AC123644
NM_001411655.1 → NP_001398584.1 autotaxin isoform 9

Status: REVIEWED

Description

Transcript Variant: This variant (9) uses an alternate exon 1 and lacks an in-frame exon, compared to variant 1. The encoded isoform (9) has a distinct N-terminus and is shorter, compared to isoform 1.

Source sequence(s)

AC123644
NM_001411656.1 → NP_001398585.1 autotaxin isoform 10

Status: REVIEWED

Description

Transcript Variant: This variant (10) uses an alternate exon 1, uses an alternate in-frame splice site in the central coding region, and lacks an in-frame exon, compared to variant 1. The encoded isoform (10) has a distinct N-terminus and is shorter, compared to isoform 1.

Source sequence(s)

AC123644
NM_001411657.1 → NP_001398586.1 autotaxin isoform 11

Status: REVIEWED

Description

Transcript Variant: This variant (11) uses an alternate exon 1, lacks an in-frame exon, and contains an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (11) has a distinct N-terminus and is shorter, compared to isoform 1.

Source sequence(s)

AC123644
NM_001411658.1 → NP_001398587.1 autotaxin isoform 12

Status: REVIEWED

Description

Transcript Variant: This variant (12) uses an alternate exon 1, lacks an in-frame exon, uses an alternate in-frame splice site, and contains an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (12) has a distinct N-terminus and is shorter, compared to isoform 1.

Source sequence(s)

AC123644
NM_015744.4 → NP_056559.2 autotaxin isoform 2 preproprotein

See identical proteins and their annotated locations for NP_056559.2

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as beta) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AK161144, BY123373, CD741437

Consensus CDS

CCDS27472.1

UniProtKB/Swiss-Prot

A8UH85, A8UH93, B2ZP54, Q6PDE0, Q99LG9, Q9R1E6

Related

ENSMUSP00000036180.10, ENSMUST00000041591.16

Conserved Domains (4) summary

smart00201
Location:56 → 97

SO; Somatomedin B -like domains

smart00477
Location:614 → 844

NUC; DNA/RNA non-specific endonuclease

pfam01663
Location:165 → 477

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cd16018
Location:163 → 517

Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

54702297..54816284 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017316505.3 → XP_017171994.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X17

Conserved Domains (3) summary

smart00201
Location:118 → 159

SO; Somatomedin B -like domains

pfam01663
Location:227 → 539

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cl00089
Location:676 → 774

NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
XM_036159254.1 → XP_036015147.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X15

Conserved Domains (3) summary

smart00201
Location:118 → 159

SO; Somatomedin B -like domains

pfam01663
Location:227 → 591

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cl00089
Location:724 → 822

NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
XM_036159246.1 → XP_036015139.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X4

Conserved Domains (3) summary

smart00201
Location:118 → 159

SO; Somatomedin B -like domains

smart00477
Location:724 → 954

NUC; DNA/RNA non-specific endonuclease

pfam01663
Location:227 → 591

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
XM_036159244.1 → XP_036015137.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X2

Conserved Domains (3) summary

smart00201
Location:118 → 159

SO; Somatomedin B -like domains

smart00477
Location:749 → 979

NUC; DNA/RNA non-specific endonuclease

pfam01663
Location:227 → 591

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
XM_036159252.1 → XP_036015145.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X13

Conserved Domains (3) summary

smart00201
Location:118 → 159

SO; Somatomedin B -like domains

pfam01663
Location:227 → 591

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cl00089
Location:728 → 826

NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
XM_036159245.1 → XP_036015138.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X3

Conserved Domains (3) summary

smart00201
Location:118 → 159

SO; Somatomedin B -like domains

smart00477
Location:728 → 958

NUC; DNA/RNA non-specific endonuclease

pfam01663
Location:227 → 591

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
XM_036159250.1 → XP_036015143.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X11

Conserved Domains (3) summary

smart00201
Location:118 → 159

SO; Somatomedin B -like domains

pfam01663
Location:227 → 591

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cl00089
Location:753 → 851

NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
XM_036159243.1 → XP_036015136.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X1

Conserved Domains (3) summary

smart00201
Location:118 → 159

SO; Somatomedin B -like domains

smart00477
Location:753 → 983

NUC; DNA/RNA non-specific endonuclease

pfam01663
Location:227 → 591

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
XM_036159249.1 → XP_036015142.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X8

Conserved Domains (3) summary

smart00201
Location:56 → 97

SO; Somatomedin B -like domains

smart00477
Location:691 → 921

NUC; DNA/RNA non-specific endonuclease

pfam01663
Location:165 → 529

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
XM_036159247.1 → XP_036015140.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X5

Conserved Domains (3) summary

smart00201
Location:118 → 159

SO; Somatomedin B -like domains

smart00477
Location:753 → 944

NUC; DNA/RNA non-specific endonuclease

pfam01663
Location:227 → 591

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
XM_036159251.1 → XP_036015144.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X12

Conserved Domains (3) summary

smart00201
Location:118 → 159

SO; Somatomedin B -like domains

pfam01663
Location:227 → 591

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cl00089
Location:753 → 851

NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.