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Pax2 paired box 2 [ Mus musculus (house mouse) ]

Gene ID: 18504, updated on 25-Jun-2019

Summary

Official Symbol
Pax2provided by MGI
Official Full Name
paired box 2provided by MGI
Primary source
MGI:MGI:97486
See related
Ensembl:ENSMUSG00000004231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Opdc; Pax-2
Expression
Biased expression in kidney adult (RPKM 7.7), genital fat pad adult (RPKM 5.8) and 7 other tissues See more
Orthologs

Genomic context

See Pax2 in Genome Data Viewer
Location:
19 C3; 19 38.09 cM
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (44745693..44837871)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (44831884..44910517)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 26644 Neighboring gene predicted gene, 35610 Neighboring gene RIKEN cDNA 1700039E22 gene Neighboring gene microRNA 6405 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene SMC5-SMC6 complex localization factor 2 Neighboring gene RIKEN cDNA 4930414N06 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
C2H2 zinc finger domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
brain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in ureteric bud morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
central nervous system development IEP
Inferred from Expression Pattern
more info
PubMed 
cochlea development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cochlea morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
cochlea morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopaminergic neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
inner ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
kidney development IGI
Inferred from Genetic Interaction
more info
PubMed 
kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesenchymal to epithelial transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesenchymal to epithelial transition involved in metanephros morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
mesodermal cell fate specification IDA
Inferred from Direct Assay
more info
PubMed 
mesonephric duct development IEP
Inferred from Expression Pattern
more info
PubMed 
mesonephric duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesonephric tubule development IEP
Inferred from Expression Pattern
more info
PubMed 
mesonephric tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesonephric tubule formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesonephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephric collecting duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephric distal convoluted tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephric epithelium development IEP
Inferred from Expression Pattern
more info
PubMed 
metanephric mesenchymal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephric mesenchyme development IDA
Inferred from Direct Assay
more info
PubMed 
metanephric nephron tubule formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephros development IGI
Inferred from Genetic Interaction
more info
PubMed 
metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process involved in metanephric collecting duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process involved in metanephric nephron tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytolysis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mesenchymal cell apoptotic process involved in metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
nephric duct formation IDA
Inferred from Direct Assay
more info
PubMed 
neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
optic chiasma development IMP
Inferred from Mutant Phenotype
more info
PubMed 
optic cup morphogenesis involved in camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
optic nerve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
optic nerve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
optic nerve structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
pancreas development IEP
Inferred from Expression Pattern
more info
PubMed 
paramesonephric duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of metanephric DCT cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of metanephric glomerulus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of optic nerve formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
pronephric field specification IEP
Inferred from Expression Pattern
more info
PubMed 
pronephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of metanephric nephron tubule epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of metanephros size IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of metanephros size ISO
Inferred from Sequence Orthology
more info
 
regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
retinal pigment epithelium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
stem cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
ureter development IMP
Inferred from Mutant Phenotype
more info
PubMed 
ureter maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ureter morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
ureter morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
ureteric bud development IGI
Inferred from Genetic Interaction
more info
PubMed 
urogenital system development IGI
Inferred from Genetic Interaction
more info
PubMed 
urogenital system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
vestibulocochlear nerve formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
paired box protein Pax-2
Names
optic disc coloboma
paired box gene 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368743.1NP_001355672.1  paired box protein Pax-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131105, AC138457
  2. NM_001368744.1NP_001355673.1  paired box protein Pax-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC131105, AC138457
  3. NM_001368745.1NP_001355674.1  paired box protein Pax-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC131105, AC138457
  4. NM_001368746.1NP_001355675.1  paired box protein Pax-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC131105, AC138457
    Conserved Domains (3) summary
    smart00351
    Location:15139
    PAX; Paired Box domain
    pfam12403
    Location:304414
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:254277
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  5. NM_001368747.1NP_001355676.1  paired box protein Pax-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC131105, AC138457
  6. NM_001368748.1NP_001355677.1  paired box protein Pax-2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC131105, AC138457
  7. NM_001368749.1NP_001355678.1  paired box protein Pax-2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC131105, AC138457
  8. NM_001368750.1NP_001355679.1  paired box protein Pax-2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC131105, AC138457
  9. NM_001368751.1NP_001355680.1  paired box protein Pax-2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC131105, AC138457
  10. NM_011037.5NP_035167.4  paired box protein Pax-2 isoform 7

    See identical proteins and their annotated locations for NP_035167.4

    Status: VALIDATED

    Source sequence(s)
    AC131105, AC138457
    Consensus CDS
    CCDS37998.2
    UniProtKB/Swiss-Prot
    P32114
    UniProtKB/TrEMBL
    A0A0R4J267
    Related
    ENSMUSP00000134661.1, ENSMUST00000174490.8
    Conserved Domains (3) summary
    smart00351
    Location:16140
    PAX; Paired Box domain
    pfam12403
    Location:282392
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:232255
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

    Range
    44745693..44837871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247161.2XP_011245463.1  paired box protein Pax-2 isoform X6

    Conserved Domains (3) summary
    smart00351
    Location:47171
    PAX; Paired Box domain
    pfam12403
    Location:336393
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:286309
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. XM_006526756.3XP_006526819.1  paired box protein Pax-2 isoform X9

    Conserved Domains (3) summary
    smart00351
    Location:47171
    PAX; Paired Box domain
    pfam12403
    Location:336398
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:286309
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  3. XM_006526749.3XP_006526812.1  paired box protein Pax-2 isoform X1

    Conserved Domains (3) summary
    smart00351
    Location:47171
    PAX; Paired Box domain
    pfam12403
    Location:336421
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:286309
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  4. XM_006526750.3XP_006526813.1  paired box protein Pax-2 isoform X2

    Conserved Domains (3) summary
    smart00351
    Location:46170
    PAX; Paired Box domain
    pfam12403
    Location:335420
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:285308
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  5. XM_006526757.3XP_006526820.1  paired box protein Pax-2 isoform X10

    Conserved Domains (3) summary
    smart00351
    Location:47171
    PAX; Paired Box domain
    pfam12403
    Location:313375
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:263286
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  6. XM_006526753.3XP_006526816.1  paired box protein Pax-2 isoform X5

    Conserved Domains (3) summary
    smart00351
    Location:47171
    PAX; Paired Box domain
    pfam12403
    Location:313398
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:263286
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  7. XM_006526751.3XP_006526814.1  paired box protein Pax-2 isoform X3

    Conserved Domains (3) summary
    smart00351
    Location:47171
    PAX; Paired Box domain
    pfam12403
    Location:336446
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:286309
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  8. XM_006526752.3XP_006526815.1  paired box protein Pax-2 isoform X4

    Conserved Domains (3) summary
    smart00351
    Location:46170
    PAX; Paired Box domain
    pfam12403
    Location:335445
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:285308
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  9. XM_006526754.3XP_006526817.1  paired box protein Pax-2 isoform X7

    Conserved Domains (3) summary
    smart00351
    Location:47171
    PAX; Paired Box domain
    pfam12403
    Location:313423
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:263286
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  10. XM_006526755.3XP_006526818.1  paired box protein Pax-2 isoform X8

    Conserved Domains (3) summary
    smart00351
    Location:46170
    PAX; Paired Box domain
    pfam12403
    Location:312422
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:262285
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  11. XM_006526758.3XP_006526821.1  paired box protein Pax-2 isoform X11

    Conserved Domains (3) summary
    smart00351
    Location:16140
    PAX; Paired Box domain
    pfam12403
    Location:305390
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:255278
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
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