U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DUSP1 dual specificity phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 1843, updated on 17-Jun-2024

Summary

Official Symbol
DUSP1provided by HGNC
Official Full Name
dual specificity phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:3064
See related
Ensembl:ENSG00000120129 MIM:600714; AllianceGenome:HGNC:3064
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HVH1; MKP1; CL100; MKP-1; PTPN10
Summary
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in gall bladder (RPKM 359.2), prostate (RPKM 315.6) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DUSP1 in Genome Data Viewer
Location:
5q35.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (172768096..172771195, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (173308211..173311310, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (172195099..172198198, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene neuralized E3 ubiquitin protein ligase 1B Neighboring gene uncharacterized LOC107986479 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23640 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23641 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172139792-172140399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172141615-172142220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172153656-172154156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172170835-172171336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172171337-172171836 Neighboring gene heart enhancer 25 Neighboring gene uncharacterized LOC101928093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23642 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:172194940-172195132 Neighboring gene VISTA enhancer hs1828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16625 Neighboring gene uncharacterized LOC105377730 Neighboring gene cyclin Q pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172214701-172215202 Neighboring gene CRISPRi-validated cis-regulatory element chr5.4451 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172232818-172233634 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:172233916-172235115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172246893-172247394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172250515-172251016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172251017-172251516 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16627 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16629 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:172262000-172262992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:172262993-172263984 Neighboring gene uncharacterized LOC124901135 Neighboring gene endoplasmic reticulum-golgi intermediate compartment 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of dual specificity protein phosphatase 1 (DUSP1) by siRNAs significantly enhances HIV-1 replication in human acute monocytic leukemia cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef inhibits TNF-alpha release and enhances the expression of MKP-1 in human macrophages PubMed
Tat tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of MKP-1 PubMed
Vif vif HIV-1 Vif upregulates the expression of dual specificity phosphatase 1 (DUSP1) in Vif-expression T cells PubMed
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MAP kinase tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase tyrosine/serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables mitogen-activated protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cellular response to chemokine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoderm formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of meiotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of monocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of p38MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peptidyl-threonine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peptidyl-tyrosine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase 1
Names
CL 100
MAP kinase phosphatase 1
dual specificity protein phosphatase hVH1
mitogen-activated protein kinase phosphatase 1
protein-tyrosine phosphatase CL100
serine/threonine specific protein phosphatase
NP_004408.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004417.4NP_004408.1  dual specificity protein phosphatase 1

    See identical proteins and their annotated locations for NP_004408.1

    Status: REVIEWED

    Source sequence(s)
    AK300487, BC022463
    Consensus CDS
    CCDS4380.1
    UniProtKB/Swiss-Prot
    D3DQL9, P28562, Q2V508
    UniProtKB/TrEMBL
    B4DRR4
    Related
    ENSP00000239223.3, ENST00000239223.4
    Conserved Domains (2) summary
    cd01446
    Location:7136
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    cd14638
    Location:174324
    DSP_DUSP1; dual specificity phosphatase domain of dual specificity protein phosphatase 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    172768096..172771195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    173308211..173311310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)