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DUSP1 dual specificity phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 1843, updated on 16-Feb-2020

Summary

Official Symbol
DUSP1provided by HGNC
Official Full Name
dual specificity phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:3064
See related
Ensembl:ENSG00000120129 MIM:600714
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HVH1; MKP1; CL100; MKP-1; PTPN10
Summary
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in gall bladder (RPKM 359.2), prostate (RPKM 315.6) and 24 other tissues See more
Orthologs

Genomic context

See DUSP1 in Genome Data Viewer
Location:
5q35.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (172768096..172771195, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (172195093..172198203, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene heart enhancer 25 Neighboring gene uncharacterized LOC101928093 Neighboring gene cyclin Q pseudogene Neighboring gene VISTA enhancer hs1828 Neighboring gene uncharacterized LOC105377730 Neighboring gene CRISPRi-validated cis-regulatory element chr5.4451

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of dual specificity protein phosphatase 1 (DUSP1) by siRNAs significantly enhances HIV-1 replication in human acute monocytic leukemia cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef inhibits TNF-alpha release and enhances the expression of MKP-1 in human macrophages PubMed
Tat tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of MKP-1 PubMed
Vif vif HIV-1 Vif upregulates the expression of dual specificity phosphatase 1 (DUSP1) in Vif-expression T cells PubMed
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase tyrosine/serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
growth factor binding IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to chemokine IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
inactivation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inactivation of MAPK activity ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle arrest ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of meiotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of monocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-threonine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of mitotic cell cycle spindle assembly checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
 
response to cAMP IEA
Inferred from Electronic Annotation
more info
 
response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
response to light stimulus IEA
Inferred from Electronic Annotation
more info
 
response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
response to testosterone IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase 1
Names
CL 100
MAP kinase phosphatase 1
dual specificity protein phosphatase hVH1
mitogen-activated protein kinase phosphatase 1
protein-tyrosine phosphatase CL100
serine/threonine specific protein phosphatase
NP_004408.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004417.4NP_004408.1  dual specificity protein phosphatase 1

    See identical proteins and their annotated locations for NP_004408.1

    Status: REVIEWED

    Source sequence(s)
    AK300487, BC022463
    Consensus CDS
    CCDS4380.1
    UniProtKB/Swiss-Prot
    P28562
    UniProtKB/TrEMBL
    B4DU40
    Related
    ENSP00000239223.3, ENST00000239223.4
    Conserved Domains (2) summary
    cd00127
    Location:173309
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:7136
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    172768096..172771195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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