Dusp1 dual specificity phosphatase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dusp1provided by MGI
Official Full Name: dual specificity phosphatase 1provided by MGI
Primary source: MGI:MGI:105120
See related: Ensembl:ENSMUSG00000024190 AllianceGenome:MGI:105120
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: erp; MKP1; mkp-1; 3CH134; Ptpn16
Summary: Enables mitogen-activated protein kinase binding activity and phosphoprotein phosphatase activity. Involved in negative regulation of MAPK cascade; negative regulation of cell population proliferation; and protein dephosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; limb; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human DUSP1 (dual specificity phosphatase 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in lung adult (RPKM 117.9), heart adult (RPKM 43.4) and 28 other tissues See more
Orthologs: all
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Genomic context

Location:: 17 A3.3; 17 13.28 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (26724565..26727446, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (26505591..26508472, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhanced MAPK signaling induced by CSF3R mutants confers dependence to DUSP1 for leukemic transformation.
Title: Enhanced MAPK signaling induced by CSF3R mutants confers dependence to DUSP1 for leukemic transformation.
CCR7/DUSP1 signaling Axis mediates iCAF to regulates head and neck squamous cell carcinoma growth.
Title: CCR7/DUSP1 signaling Axis mediates iCAF to regulates head and neck squamous cell carcinoma growth.
Dual-specificity phosphatase 1 interacts with prohibitin 2 to improve mitochondrial quality control against type-3 cardiorenal syndrome.
Title: Dual-specificity phosphatase 1 interacts with prohibitin 2 to improve mitochondrial quality control against type-3 cardiorenal syndrome.
MKP-1 regulates the inflammatory activation of microglia against Alzheimer's disease.
Title: MKP-1 regulates the inflammatory activation of microglia against Alzheimer's disease.
Heat shock induces HuR-dependent MKP-1 posttranslational regulation through the p38 MAPK signaling cascade.
Title: Heat shock induces HuR-dependent MKP-1 posttranslational regulation through the p38 MAPK signaling cascade.
DUSP1 protects against ischemic acute kidney injury through stabilizing mtDNA via interaction with JNK.
Title: DUSP1 protects against ischemic acute kidney injury through stabilizing mtDNA via interaction with JNK.
ANGPTL2 aggravates LPS-induced septic cardiomyopathy via NLRP3-mediated inflammasome in a DUSP1-dependent pathway.
Title: ANGPTL2 aggravates LPS-induced septic cardiomyopathy via NLRP3-mediated inflammasome in a DUSP1-dependent pathway.
MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention.
Title: MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention.
DUSP1 interacts with and dephosphorylates VCP to improve mitochondrial quality control against endotoxemia-induced myocardial dysfunction.
Title: DUSP1 interacts with and dephosphorylates VCP to improve mitochondrial quality control against endotoxemia-induced myocardial dysfunction.
p38 MAPK and MKP-1 control the glycolytic program via the bifunctional glycolysis regulator PFKFB3 during sepsis.
Title: p38 MAPK and MKP-1 control the glycolytic program via the bifunctional glycolysis regulator PFKFB3 during sepsis.

Submit: New GeneRIF Correction See all GeneRIFs (164)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC156147P11 (e-PCR)
- UniSTS:271370

RH125291 (e-PCR)
- UniSTS:162113

G06586 (e-PCR)
- UniSTS:51801

Dusp1 (e-PCR), detects polymorphism
- UniSTS:525482

Dusp1 (e-PCR), detects polymorphism
- UniSTS:506862

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables MAP kinase tyrosine/serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables mitogen-activated protein kinase binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphoprotein phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	EXP Inferred from Experiment more info	PubMed
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine phosphatase activity	EXP Inferred from Experiment more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in cellular response to chemokine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to chemokine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in endoderm formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of meiotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of monocyte chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of p38MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of p38MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-threonine dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle spindle assembly checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
involved_in response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in response to light stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in response to testosterone	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dual specificity protein phosphatase 1

Names: MAP kinase phosphatase 1; mitogen-activated protein kinase phosphatase-1; protein tyrosine phosphatase, non-receptor type 16; protein-tyrosine phosphatase 3CH134; protein-tyrosine phosphatase ERP

NP_038670.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013642.3 → NP_038670.1 dual specificity protein phosphatase 1

See identical proteins and their annotated locations for NP_038670.1

Status: VALIDATED

Source sequence(s)

AK159251, U19515

Consensus CDS

CCDS28552.1

UniProtKB/Swiss-Prot

P28563

UniProtKB/TrEMBL

Q3U8K3, Q3UCQ6

Related

ENSMUSP00000025025.7, ENSMUST00000025025.7

Conserved Domains (3) summary

COG2453
Location:188 → 313

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

cd00127
Location:173 → 309

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

cd01446
Location:7 → 136

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...