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let-4 Leucine-rich repeat-containing protein let-4 [ Caenorhabditis elegans ]

Gene ID: 181554, updated on 18-Sep-2024

Summary

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Official Symbol
let-4
Official Full Name
Leucine-rich repeat-containing protein let-4
Primary source
WormBase:WBGene00002282
Locus tag
CELE_C44H4.2
See related
AllianceGenome:WB:WBGene00002282
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in several processes, including epithelial cell development; nematode larval development; and positive regulation of membrane permeability. Located in apical part of cell. Is expressed in excretory system; hypodermis; rectal epithelial cell; and vulva. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (14577935..14580923)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Chorein N-terminal domain-containing protein Neighboring gene LRRCT domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Leucine-rich repeat-containing protein let-4 Neighboring gene ncRNA Neighboring gene TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Integrity of Narrow Epithelial Tubes in the C. elegans Excretory System Requires a Transient Luminal Matrix. Gill HK, et al. PLoS Genet, 2016 Aug. PMID 27482894, Free PMC Article
  2. Suppression and function of X-linked lethal and sterile mutations in Caenorhabditis elegans. Meneely PM, et al. Genetics, 1981 Jan. PMID 7196363, Free PMC Article
  3. Lethals, steriles and deficiencies in a region of the X chromosome of Caenorhabditis elegans. Meneely PM, et al. Genetics, 1979 May. PMID 574105, Free PMC Article
  4. The apical ECM preserves embryonic integrity and distributes mechanical stress during morphogenesis. Vuong-Brender TTK, et al. Development, 2017 Dec 1. PMID 28526752, Free PMC Article
  5. Extracellular leucine-rich repeat proteins are required to organize the apical extracellular matrix and maintain epithelial junction integrity in C. elegans. Mancuso VP, et al. Development, 2012 Mar. PMID 22278925, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of membrane permeability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Leucine-rich repeat-containing protein let-4
NP_510425.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    14577935..14580923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078024.5 → NP_510425.2  Leucine-rich repeat-containing protein let-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510425.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q93373
    Conserved Domains (3) summary
    cd00116
    Location:250 → 411
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:88 → 111
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:256 → 316
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q93373.2

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