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Npas2 neuronal PAS domain protein 2 [ Mus musculus (house mouse) ]

Gene ID: 18143, updated on 12-Aug-2019

Summary

Official Symbol
Npas2provided by MGI
Official Full Name
neuronal PAS domain protein 2provided by MGI
Primary source
MGI:MGI:109232
See related
Ensembl:ENSMUSG00000026077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MOP4; bHLHe9
Summary
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. The encoded protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Dec 2014]
Expression
Broad expression in small intestine adult (RPKM 16.1), colon adult (RPKM 13.4) and 17 other tissues See more
Orthologs

Genomic context

See Npas2 in Genome Data Viewer
Location:
1 B; 1 17.98 cM
Exon count:
22
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (39193702..39363240)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (39251117..39420085)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35222 Neighboring gene microRNA 6349 Neighboring gene mitochondrial pyruvate carrier 1 pseudogene Neighboring gene microrchidia 2A pseudogene Neighboring gene ribosomal protein L17 pseudogene Neighboring gene TBC1 domain family, member 8 Neighboring gene ribosomal protein L31 Neighboring gene predicted gene, 24826

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129355

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
circadian sleep/wake cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
positive regulation of behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to drug IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to redox state IDA
Inferred from Direct Assay
more info
PubMed 
response to redox state ISO
Inferred from Sequence Orthology
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neuronal PAS domain-containing protein 2
Names
neuronal PAS2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008719.2NP_032745.2  neuronal PAS domain-containing protein 2

    See identical proteins and their annotated locations for NP_032745.2

    Status: VALIDATED

    Source sequence(s)
    BB524729, BC109166, BG070037, U77969
    Consensus CDS
    CCDS48244.1
    UniProtKB/Swiss-Prot
    P97460
    UniProtKB/TrEMBL
    G3X9B7, Q32ME6
    Related
    ENSMUSP00000054719.7, ENSMUST00000056815.8
    Conserved Domains (5) summary
    smart00091
    Location:84149
    PAS; PAS domain
    cd00083
    Location:761
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:250350
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam13426
    Location:97195
    PAS_9; PAS domain
    pfam14598
    Location:249352
    PAS_11; PAS domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p6 C57BL/6J

    Range
    39193702..39363240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238452.3XP_011236754.1  neuronal PAS domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011236754.1

    UniProtKB/TrEMBL
    G3X9B7
    Conserved Domains (5) summary
    smart00091
    Location:84149
    PAS; PAS domain
    cd00083
    Location:761
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:250350
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam13426
    Location:97195
    PAS_9; PAS domain
    pfam14598
    Location:249352
    PAS_11; PAS domain
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