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DPT dermatopontin [ Homo sapiens (human) ]

Gene ID: 1805, updated on 5-Aug-2022

Summary

Official Symbol
DPTprovided by HGNC
Official Full Name
dermatopontinprovided by HGNC
Primary source
HGNC:HGNC:3011
See related
Ensembl:ENSG00000143196 MIM:125597; AllianceGenome:HGNC:3011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRAMP
Summary
Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 269.7), heart (RPKM 73.0) and 14 other tissues See more
Orthologs
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Genomic context

See DPT in Genome Data Viewer
Location:
1q24.2
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (168695468..168729206, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (168050592..168084377, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (168664706..168698444, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7a pseudogene 21 Neighboring gene X-C motif chemokine ligand 1 Neighboring gene uncharacterized LOC105371604 Neighboring gene uncharacterized LOC124904452 Neighboring gene long intergenic non-protein coding RNA 626

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
EBI GWAS Catalog
Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef-induced upregulation of tyrosine-rich acidic matrix protein (TRAMP) is found in Nef expressing HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
dermatopontin
Names
tyrosine-rich acidic matrix protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001937.5NP_001928.2  dermatopontin precursor

    See identical proteins and their annotated locations for NP_001928.2

    Status: VALIDATED

    Source sequence(s)
    AL049798, BC033736, BP257325
    Consensus CDS
    CCDS1275.1
    UniProtKB/Swiss-Prot
    Q07507, Q9UIX8
    Related
    ENSP00000356791.3, ENST00000367817.4
    Conserved Domains (1) summary
    pfam14704
    Location:43192
    DERM; Dermatopontin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    168695468..168729206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    168050592..168084377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)