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DPT dermatopontin [ Homo sapiens (human) ]

Gene ID: 1805, updated on 22-Aug-2020

Summary

Official Symbol
DPTprovided by HGNC
Official Full Name
dermatopontinprovided by HGNC
Primary source
HGNC:HGNC:3011
See related
Ensembl:ENSG00000143196 MIM:125597
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRAMP
Summary
Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 269.7), heart (RPKM 73.0) and 14 other tissues See more
Orthologs

Genomic context

See DPT in Genome Data Viewer
Location:
1q24.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (168695468..168729206, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (168664695..168698442, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7a pseudogene 21 Neighboring gene X-C motif chemokine ligand 1 Neighboring gene uncharacterized LOC105371604 Neighboring gene long intergenic non-protein coding RNA 626 Neighboring gene uncharacterized LOC105371606

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
GeneReviews: Not available
Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef-induced upregulation of tyrosine-rich acidic matrix protein (TRAMP) is found in Nef expressing HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular matrix structural constituent ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
collagen fibril organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dermatopontin
Names
tyrosine-rich acidic matrix protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001937.5NP_001928.2  dermatopontin precursor

    See identical proteins and their annotated locations for NP_001928.2

    Status: VALIDATED

    Source sequence(s)
    AL049798, BC033736, BP257325
    Consensus CDS
    CCDS1275.1
    UniProtKB/Swiss-Prot
    Q07507
    Related
    ENSP00000356791.3, ENST00000367817.4
    Conserved Domains (1) summary
    pfam14704
    Location:43192
    DERM; Dermatopontin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    168695468..168729206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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