DPT dermatopontin [Homo sapiens (human)] - Gene

Summary

Official Symbol: DPTprovided by HGNC
Official Full Name: dermatopontinprovided by HGNC
Primary source: HGNC:HGNC:3011
See related: Ensembl:ENSG00000143196 MIM:125597
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TRAMP
Summary: Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin. [provided by RefSeq, Jul 2008]
Expression: Broad expression in fat (RPKM 269.7), heart (RPKM 73.0) and 14 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 1q24.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109.20200815	current	GRCh38.p13 (GCF_000001405.39)	1	NC_000001.11 (168695468..168729206, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (168664695..168698442, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DPT regulates CDK4, CDK6 and p21, through MEK-ERK-MYC signaling to repress papillary thyroid cancer proliferation.
Title: Dermatopontin inhibits papillary thyroid cancer cell proliferation through MYC repression.
DPT gene silencing could effectively reduce the proliferation of MG-63 cells, slow down the cell cycle progression and promote cell apoptosis.
Title: Effects of Dermatopontin gene silencing on apoptosis and proliferation of osteosarcoma MG‑63 cells.
Novel mutation in DPT segregates with the complete phenotype with variable expressivity in two pedigrees with autosomal dominant familial Meniere's disease.
Title: Variable expressivity and genetic heterogeneity involving DPT and SEMA3D genes in autosomal dominant familial Meniere's disease.
This study essentially deals with assessing the expression and integrity of an extracellular matrix protein, Dermatopontin (DPT), in chronic cutaneous wounds.
Title: Expression and integrity of dermatopontin in chronic cutaneous wounds: a crucial factor in impaired wound healing.
dermatopontin functional peptide produces fibrinogen fibrils and modifies its biological activity
Title: Functional peptide of dermatopontin produces fibrinogen fibrils and modifies its biological activity.
Lumican, decorin and dermatopontin are differentially expressed and may serve as biomarkers for metastatic and recurrent Giant cell tumor of bone
Title: Gene expression profiling of giant cell tumor of bone reveals downregulation of extracellular matrix components decorin and lumican associated with lung metastasis.
The obtained results indicate that the changes in gene expression in bone marrow progenitor cells can be involved into space flight-induced osteopenia.
Title: [The effects of simulated microgravity on the pattern of gene expression in human bone marrow mesenchymal stem cells under osteogenic differentiation].
These results indicate that DPT can modify certain biological functions of fibrin, and thus a another function of this extracellular matrix protein was revealed.
Title: Dermatopontin regulates fibrin formation and its biological activity.
data provided strong evidence that downregulation of DPT is a characteristic event in human oral squamous cell carcinoma and that DPT was correlated with cellular adhesion and invasiveness.
Title: Dermatopontin: a potential predictor for metastasis of human oral cancer.
DPT has an accelerating role in fibroblast cell adhesion to the provisional matrix in the initial stage of wound healing.
Title: Dermatopontin interacts with fibronectin, promotes fibronectin fibril formation, and enhances cell adhesion.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. GeneReviews: Not available
Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	HIV-1 Nef-induced upregulation of tyrosine-rich acidic matrix protein (TRAMP) is found in Nef expressing HeLa cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH103231 (e-PCR)
- UniSTS:97563

RH92745 (e-PCR)
- UniSTS:86879

RH36563 (e-PCR)
- UniSTS:31366

AL009391 (e-PCR)
- UniSTS:11671

SHGC-75872 (e-PCR)
- UniSTS:80307

Homology

Homologs of the DPT gene: The DPT gene is conserved in chimpanzee, dog, cow, mouse, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 333 organisms have orthologs with human gene DPT
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
extracellular matrix structural constituent	ISS Inferred from Sequence or Structural Similarity more info
extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cell adhesion	IEA Inferred from Electronic Annotation more info
collagen fibril organization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
negative regulation of cell proliferation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
collagen-containing extracellular matrix	HDA more info	PubMed
colocalizes_with collagen-containing extracellular matrix	HDA more info	PubMed
colocalizes_with collagen-containing extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info	PubMed
extracellular space	HDA more info	PubMed

General protein information

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Preferred Names: dermatopontin

Names: tyrosine-rich acidic matrix protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.