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hif-1 Hypoxia-inducible factor 1 [ Caenorhabditis elegans ]

Gene ID: 180359, updated on 19-Aug-2018

Summary

Gene symbol
hif-1
Gene description
Hypoxia-inducible factor 1
Primary source
WormBase:WBGene00001851
Locus tag
CELE_F38A6.3
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See hif-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
11
Sequence:
Chromosome: V; NC_003283.11 (20780502..20784861)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to caloric restriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
heat acclimation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to axon injury IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hypoxia IGI
Inferred from Genetic Interaction
more info
PubMed 
response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Hypoxia-inducible factor 1
NP_001023891.2
  • Confirmed by transcript evidence
NP_001023892.1
  • Confirmed by transcript evidence
NP_001023893.1
  • Confirmed by transcript evidence
NP_001023894.2
  • Confirmed by transcript evidence
NP_001299994.1
  • Confirmed by transcript evidence
NP_508008.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20780502..20784861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028720.3NP_001023891.2  Hypoxia-inducible factor 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023891.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGD2
    Conserved Domains (3) summary
    cd00083
    Location:1066
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:94145
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam14598
    Location:236338
    PAS_11; PAS domain
  2. NM_075607.5NP_508008.4  Hypoxia-inducible factor 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508008.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGD2
    Conserved Domains (3) summary
    cd00083
    Location:1066
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:94145
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam14598
    Location:236338
    PAS_11; PAS domain
  3. NM_001028722.3NP_001023893.1  Hypoxia-inducible factor 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023893.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGD2
    Conserved Domains (4) summary
    smart00091
    Location:89142
    PAS; PAS domain
    cd00083
    Location:1066
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:233312
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam14598
    Location:236338
    PAS_11; PAS domain
  4. NM_001313065.1NP_001299994.1  Hypoxia-inducible factor 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AXG6
    Conserved Domains (3) summary
    cd00083
    Location:258
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:86137
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam14598
    Location:228330
    PAS_11; PAS domain
  5. NM_001028723.2NP_001023894.2  Hypoxia-inducible factor 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023894.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGD2
    Conserved Domains (3) summary
    cd00083
    Location:258
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:86137
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam14598
    Location:228330
    PAS_11; PAS domain
  6. NM_001028721.2NP_001023892.1  Hypoxia-inducible factor 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023892.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGD2
    Conserved Domains (2) summary
    cd00130
    Location:1796
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam14598
    Location:20122
    PAS_11; PAS domain
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