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Myb myeloblastosis oncogene [ Mus musculus (house mouse) ]

Gene ID: 17863, updated on 12-May-2024

Summary

Official Symbol
Mybprovided by MGI
Official Full Name
myeloblastosis oncogeneprovided by MGI
Primary source
MGI:MGI:97249
See related
Ensembl:ENSMUSG00000019982 AllianceGenome:MGI:97249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
c-myb
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and WD40-repeat domain binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cellular response to cytokine stimulus; embryonic digestive tract development; and hematopoietic or lymphoid organ development. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study essential thrombocythemia and myelofibrosis. Orthologous to human MYB (MYB proto-oncogene, transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 78.6), liver E14 (RPKM 10.2) and 4 other tissues See more
Orthologs
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Genomic context

See Myb in Genome Data Viewer
Location:
10 A3; 10 9.75 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (21000829..21036883, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (21124930..21160984, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53617 Neighboring gene ribosomal protein S2, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_25971 Neighboring gene STARR-positive B cell enhancer ABC_E2930 Neighboring gene Abelson helper integration site 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:20715221-20715330 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:20768493-20768817 Neighboring gene STARR-seq mESC enhancer starr_25973 Neighboring gene predicted gene, 20149 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:20812313-20812607 Neighboring gene STARR-seq mESC enhancer starr_25978 Neighboring gene STARR-seq mESC enhancer starr_25982 Neighboring gene STARR-seq mESC enhancer starr_25983 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:20906641-20906824 Neighboring gene predicted gene, 40608 Neighboring gene predicted gene, 33619

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC18531

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T-helper 2 cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to interleukin-6 IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within embryonic digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in myeloid cell development NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hepatic stellate cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hepatic stellate cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of testosterone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II EXP
Inferred from Experiment
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transforming growth factor beta production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spleen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex EXP
Inferred from Experiment
more info
PubMed 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
transcriptional activator Myb
Names
gag-myb protein
myb proto-oncogene protein
myeloblastosis proto-oncogene product
proto-oncogene c-Myb
tumor-specific myb protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198914.2NP_001185843.1  transcriptional activator Myb isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC153556
    Consensus CDS
    CCDS78800.1
    UniProtKB/TrEMBL
    A0A087WPA7, Q8BU17
    Related
    ENSMUSP00000139699.2, ENSMUST00000188495.8
    Conserved Domains (4) summary
    smart00717
    Location:92140
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:92138
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:269313
    LMSTEN; LMSTEN motif
    pfam09316
    Location:516677
    Cmyb_C; C-myb, C-terminal
  2. NM_010848.3NP_034978.3  transcriptional activator Myb isoform 2

    See identical proteins and their annotated locations for NP_034978.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AA170760, AC153556, AK132250, AK137794, AK137965, BB543454, M12848
    Consensus CDS
    CCDS35861.1
    UniProtKB/Swiss-Prot
    E9QMG8, P06876, Q61929
    UniProtKB/TrEMBL
    Q61421
    Related
    ENSMUSP00000020158.7, ENSMUST00000020158.9
    Conserved Domains (4) summary
    smart00717
    Location:92140
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:92138
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:269313
    LMSTEN; LMSTEN motif
    pfam09316
    Location:401558
    Cmyb_C; C-myb, C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    21000829..21036883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033597.1: Suppressed sequence

    Description
    NM_033597.1: This RefSeq was permanently suppressed because it is based on M16449.1 which is from lymphosarcoma tissue. Other evidence for this transcript in non-cancerous tissues does not exist.