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MYB MYB proto-oncogene, transcription factor [ Homo sapiens (human) ]

Gene ID: 4602, updated on 20-Feb-2017
Official Symbol
MYBprovided by HGNC
Official Full Name
MYB proto-oncogene, transcription factorprovided by HGNC
Primary source
HGNC:HGNC:7545
See related
Ensembl:ENSG00000118513 MIM:189990; Vega:OTTHUMG00000015629
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
efg; Cmyb; c-myb; c-myb_CDS
Summary
This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Orthologs
Location:
6q23.3
Exon count:
19
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (135180981..135219173)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (135502453..135540311)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986647 Neighboring gene uncharacterized LOC105378010 Neighboring gene uncharacterized LOC105378011 Neighboring gene microRNA 548a-2 Neighboring gene Abelson helper integration site 1 Neighboring gene beta-transducin repeat containing E3 ubiquitin protein ligase pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
NHGRI GWA Catalog
A genome-wide association identified the common genetic variants influence disease severity in beta0-thalassemia/hemoglobin E.
NHGRI GWA Catalog
A genome-wide association study of red blood cell traits using the electronic medical record.
NHGRI GWA Catalog
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
NHGRI GWA Catalog
A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.
NHGRI GWA Catalog
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog
Genome wide association analysis of a founder population identified TAF3 as a gene for MCHC in humans.
NHGRI GWA Catalog
Genome wide association study of fetal hemoglobin in sickle cell anemia in Tanzania.
NHGRI GWA Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog
GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
NHGRI GWA Catalog
HbA2 levels in normal adults are influenced by two distinct genetic mechanisms.
NHGRI GWA Catalog
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
NHGRI GWA Catalog
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
NHGRI GWA Catalog
Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
NHGRI GWA Catalog
New gene functions in megakaryopoiesis and platelet formation.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Sequence variants in three loci influence monocyte counts and erythrocyte volume.
NHGRI GWA Catalog
Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T-helper cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of collagen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hepatic stellate cell activation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hepatic stellate cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of histone H3-K4 methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone H3-K9 methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of testosterone secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transforming growth factor beta production IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear matrix NAS
Non-traceable Author Statement
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
transcriptional activator Myb
Names
oncogene AMV
proto-oncogene c-Myb
v-myb avian myeloblastosis viral oncogene homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012330.1 RefSeqGene

    Range
    5001..42859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130172.1NP_001123644.1  transcriptional activator Myb isoform 3

    See identical proteins and their annotated locations for NP_001123644.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as 8) uses an alternate in-frame splice site and lacks an in-frame exon compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AJ606320, D25774
    Consensus CDS
    CCDS47482.1
    UniProtKB/Swiss-Prot
    P10242
    Related
    ENSP00000410825, OTTHUMP00000234321, ENST00000442647, OTTHUMT00000391709
    Conserved Domains (4) summary
    smart00717
    Location:92140
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:92138
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:269313
    LMSTEN; LMSTEN motif
    pfam09316
    Location:398559
    Cmyb_C; C-myb, C-terminal
  2. NM_001130173.1NP_001123645.1  transcriptional activator Myb isoform 1

    See identical proteins and their annotated locations for NP_001123645.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as 9Aii) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AJ606319, D25774
    Consensus CDS
    CCDS47481.1
    UniProtKB/Swiss-Prot
    P10242
    Related
    ENSP00000339992, OTTHUMP00000017259, ENST00000341911, OTTHUMT00000042348
    Conserved Domains (4) summary
    smart00717
    Location:92140
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:92138
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:269313
    LMSTEN; LMSTEN motif
    pfam09316
    Location:518683
    Cmyb_C; C-myb, C-terminal
  3. NM_001161656.1NP_001155128.1  transcriptional activator Myb isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as E8SE9B) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AL023693
    Consensus CDS
    CCDS55058.1
    UniProtKB/Swiss-Prot
    P10242
    Related
    ENSP00000434723, OTTHUMP00000234431, ENST00000528774, OTTHUMT00000391902
    Conserved Domains (4) summary
    smart00717
    Location:92140
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:92138
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:269313
    LMSTEN; LMSTEN motif
    pfam09316
    Location:515680
    Cmyb_C; C-myb, C-terminal
  4. NM_001161657.1NP_001155129.1  transcriptional activator Myb isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as DelE9) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AL023693
    Consensus CDS
    CCDS55061.1
    UniProtKB/Swiss-Prot
    P10242
    Related
    ENSP00000435938, OTTHUMP00000234322, ENST00000525369, OTTHUMT00000391710
    Conserved Domains (4) summary
    smart00717
    Location:92140
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:92138
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:269313
    LMSTEN; LMSTEN motif
    pfam09316
    Location:317477
    Cmyb_C; C-myb, C-terminal
  5. NM_001161658.1NP_001155130.1  transcriptional activator Myb isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also known as E9S-48E9B) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (6) is shorter than isoform 1.
    Source sequence(s)
    AL023693
    Consensus CDS
    CCDS55059.1
    UniProtKB/Swiss-Prot
    P10242
    Related
    ENSP00000432851, OTTHUMP00000234432, ENST00000534121, OTTHUMT00000391903
    Conserved Domains (4) summary
    smart00717
    Location:92140
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:92138
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:269313
    LMSTEN; LMSTEN motif
    pfam09316
    Location:502667
    Cmyb_C; C-myb, C-terminal
  6. NM_001161659.1NP_001155131.1  transcriptional activator Myb isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7, also known as DelE13) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (7) is shorter than isoform 1.
    Source sequence(s)
    AL023693
    Consensus CDS
    CCDS55060.1
    UniProtKB/Swiss-Prot
    P10242
    Related
    ENSP00000435055, OTTHUMP00000234392, ENST00000534044, OTTHUMT00000391844
    Conserved Domains (4) summary
    smart00717
    Location:92140
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:92138
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:269313
    LMSTEN; LMSTEN motif
    pfam09316
    Location:401530
    Cmyb_C; C-myb, C-terminal
  7. NM_001161660.1NP_001155132.1  transcriptional activator Myb isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8, also known as DelE8) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (8) is shorter than isoform 1.
    Source sequence(s)
    AL023693
    Consensus CDS
    CCDS55062.1
    UniProtKB/Swiss-Prot
    P10242
    Related
    ENSP00000436605, OTTHUMP00000234393, ENST00000533624, OTTHUMT00000391846
    Conserved Domains (3) summary
    smart00717
    Location:92140
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:92138
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam09316
    Location:366527
    Cmyb_C; C-myb, C-terminal
  8. NM_005375.3NP_005366.2  transcriptional activator Myb isoform 2

    See identical proteins and their annotated locations for NP_005366.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as M15024) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC064955, D25774, X52125
    Consensus CDS
    CCDS5174.1
    UniProtKB/Swiss-Prot
    P10242
    UniProtKB/TrEMBL
    Q708E9
    Related
    ENSP00000356788, OTTHUMP00000017258, ENST00000367814, OTTHUMT00000042347
    Conserved Domains (4) summary
    smart00717
    Location:92140
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:92138
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:269313
    LMSTEN; LMSTEN motif
    pfam09316
    Location:401562
    Cmyb_C; C-myb, C-terminal

RNA

  1. NR_134958.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9, also known as E8A) contains an alternate exon and lacks an exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AJ606317, D25774
    Related
    ENST00000525477, OTTHUMT00000391705
  2. NR_134959.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10, also known as E8SE8A) uses an alternate splice site, lacks an exon, and contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AJ606321, D25774
    Related
    ENST00000463282, OTTHUMT00000391704
  3. NR_134960.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11, also known as E10A) lacks an exon and contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AJ606322, D25774
    Related
    ENST00000339290, OTTHUMT00000391708
  4. NR_134961.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12, also known as E9A or 9Ai) lacks an exon and contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AJ606318, D25774
    Related
    ENST00000533837, OTTHUMT00000391706
  5. NR_134962.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13, also known as DelE5E8A) lacks two exons and contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AJ606317, AJ606318, AY787446, D25774, X52125
  6. NR_134963.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14, also known as E12L-1) lacks an exon and uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AJ606317, AY787451, D25774, X52125
    Related
    ENST00000616088
  7. NR_134964.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15, also known as E8SE10A) uses an alternate splice site, lacks an exon, and contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AJ606317, AY787458, D25774
    Related
    ENST00000526889, OTTHUMT00000391876
  8. NR_134965.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16, also known as E8AE10A) lacks an exon and contains two alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AJ606317, AY787456, D25774
    Related
    ENST00000525514, OTTHUMT00000391853

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

    Range
    135180981..135219173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_942444.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    135764731..135802560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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