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DYNC1LI2 dynein cytoplasmic 1 light intermediate chain 2 [ Homo sapiens (human) ]

Gene ID: 1783, updated on 7-Jun-2020

Summary

Official Symbol
DYNC1LI2provided by HGNC
Official Full Name
dynein cytoplasmic 1 light intermediate chain 2provided by HGNC
Primary source
HGNC:HGNC:2966
See related
Ensembl:ENSG00000135720 MIM:611406
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIC2; DNCLI2
Summary
Cytoplasmic dynein is a microtubule-associated motor protein (Hughes et al., 1995 [PubMed 7738094]). See DYNC1H1 (MIM 600112) for general information about dyneins.[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in brain (RPKM 55.8), thyroid (RPKM 40.2) and 25 other tissues See more
Orthologs

Genomic context

See DYNC1LI2 in Genome Data Viewer
Location:
16q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (66720893..66751828, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66754796..66785526, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CKLF like MARVEL transmembrane domain containing 4 Neighboring gene CKLF like MARVEL transmembrane domain containing 3 Neighboring gene putative uncharacterized protein encoded by LINC00269 Neighboring gene uncharacterized LOC106699570 Neighboring gene telomere repeat binding bouquet formation protein 1 Neighboring gene NEDD8 activating enzyme E1 subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag HIV-1 CA uncoating is delayed in the presence of ciliobrevin D, a specific inhibitor of dynein-mediated motor function, indicating that dynein is involved in CA uncoating in cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
cellular response to nerve growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
centrosome localization IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
kinetochore IEA
Inferred from Electronic Annotation
more info
 
late endosome IEA
Inferred from Electronic Annotation
more info
 
lysosome IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytoplasmic dynein 1 light intermediate chain 2
Names
LIC-2
LIC53/55
dynein light intermediate chain 2, cytosolic
dynein, cytoplasmic, light intermediate polypeptide 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286157.1NP_001273086.1  cytoplasmic dynein 1 light intermediate chain 2 isoform 2

    See identical proteins and their annotated locations for NP_001273086.1

    Status: VALIDATED

    Source sequence(s)
    AC018557, AK303031, AL708642, BC022934
    Consensus CDS
    CCDS67049.1
    UniProtKB/Swiss-Prot
    O43237
    Related
    ENSP00000394289.2, ENST00000443351.6
    Conserved Domains (1) summary
    pfam05783
    Location:30411
    DLIC; Dynein light intermediate chain (DLIC)
  2. NM_001323955.1NP_001310884.1  cytoplasmic dynein 1 light intermediate chain 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC018557, AC044802, BC022934, BU616879, BX648863, DC417195, EB387189
    UniProtKB/TrEMBL
    Q63HJ8
    Conserved Domains (1) summary
    pfam05783
    Location:30449
    DLIC; Dynein light intermediate chain (DLIC)
  3. NM_006141.3NP_006132.1  cytoplasmic dynein 1 light intermediate chain 2 isoform 1

    See identical proteins and their annotated locations for NP_006132.1

    Status: VALIDATED

    Source sequence(s)
    AC018557, AF035812, AL708642, BC022934, BM805417, BX648863
    Consensus CDS
    CCDS10818.1
    UniProtKB/Swiss-Prot
    O43237
    UniProtKB/TrEMBL
    A0A024R6Z0, Q63HJ8
    Related
    ENSP00000258198.2, ENST00000258198.7
    Conserved Domains (1) summary
    pfam05783
    Location:30488
    DLIC; Dynein light intermediate chain (DLIC)

RNA

  1. NR_136658.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018557, AC044802, BC010928, BX648863

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    66720893..66751828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023008.2XP_016878497.1  cytoplasmic dynein 1 light intermediate chain 2 isoform X1

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