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Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 [ Mus musculus (house mouse) ]

Gene ID: 234663, updated on 5-Mar-2024

Summary

Official Symbol
Dync1li2provided by MGI
Official Full Name
dynein, cytoplasmic 1 light intermediate chain 2provided by MGI
Primary source
MGI:MGI:107738
See related
Ensembl:ENSMUSG00000035770 AllianceGenome:MGI:107738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LIC2; Dlic2; Dncli2; Dnclic2; C920003I06
Summary
Predicted to enable dynein heavy chain binding activity and identical protein binding activity. Acts upstream of or within centrosome localization and microtubule cytoskeleton organization. Predicted to be located in kinetochore. Predicted to be part of cytoplasmic dynein complex. Predicted to colocalize with centrosome; late endosome; and lysosome. Orthologous to human DYNC1LI2 (dynein cytoplasmic 1 light intermediate chain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 27.9), frontal lobe adult (RPKM 24.8) and 26 other tissues See more
Orthologs
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Genomic context

See Dync1li2 in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105144306..105170415, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104417674..104443050, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CKLF-like MARVEL transmembrane domain containing 3 Neighboring gene CKLF-like MARVEL transmembrane domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E11745 Neighboring gene telomere repeat binding bouquet formation protein 1 Neighboring gene predicted gene, 22148 Neighboring gene STARR-positive B cell enhancer ABC_E6676 Neighboring gene NEDD8 activating enzyme E1 subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to nerve growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cytoplasmic dynein complex IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of dynein complex ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytoplasmic dynein 1 light intermediate chain 2
Names
dynein light intermediate chain 2, cytosolic
dynein, cytoplasmic, light intermediate chain 2
dynein, cytoplasmic, light intermediate polypeptide 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013380.2NP_001013398.2  cytoplasmic dynein 1 light intermediate chain 2

    See identical proteins and their annotated locations for NP_001013398.2

    Status: VALIDATED

    Source sequence(s)
    AK140743, AK147899, BU850577, BY290848, CD351101
    Consensus CDS
    CCDS22579.1
    UniProtKB/Swiss-Prot
    Q3UGJ3, Q6PDL0
    UniProtKB/TrEMBL
    A0A1D5RM94
    Related
    ENSMUSP00000045480.7, ENSMUST00000041769.8
    Conserved Domains (4) summary
    cd00009
    Location:46100
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam05783
    Location:30488
    DLIC; Dynein light intermediate chain (DLIC)
    pfam13257
    Location:374473
    DUF4048; Domain of unknown function (DUF4048)
    cl21455
    Location:218294
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    105144306..105170415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530882.5XP_006530945.1  cytoplasmic dynein 1 light intermediate chain 2 isoform X3

    UniProtKB/TrEMBL
    A0A1D5RM94
    Related
    ENSMUSP00000148716.2, ENSMUST00000212230.2
    Conserved Domains (1) summary
    pfam05783
    Location:30474
    DLIC; Dynein light intermediate chain (DLIC)
  2. XM_006530881.5XP_006530944.1  cytoplasmic dynein 1 light intermediate chain 2 isoform X2

    UniProtKB/TrEMBL
    A0A1D5RM94
    Conserved Domains (1) summary
    pfam05783
    Location:30446
    DLIC; Dynein light intermediate chain (DLIC)
  3. XM_006530880.5XP_006530943.1  cytoplasmic dynein 1 light intermediate chain 2 isoform X1

    UniProtKB/TrEMBL
    A0A1D5RM94
    Conserved Domains (1) summary
    pfam05783
    Location:30460
    DLIC; Dynein light intermediate chain (DLIC)
  4. XM_006530883.5XP_006530946.1  cytoplasmic dynein 1 light intermediate chain 2 isoform X4

    Conserved Domains (1) summary
    pfam05783
    Location:30367
    DLIC; Dynein light intermediate chain (DLIC)