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DYNC1I2 dynein cytoplasmic 1 intermediate chain 2 [ Homo sapiens (human) ]

Gene ID: 1781, updated on 1-Aug-2020

Summary

Official Symbol
DYNC1I2provided by HGNC
Official Full Name
dynein cytoplasmic 1 intermediate chain 2provided by HGNC
Primary source
HGNC:HGNC:2964
See related
Ensembl:ENSG00000077380 MIM:603331
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IC2; DIC74; DNCI2; NEDMIBA
Summary
This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in brain (RPKM 28.2), endometrium (RPKM 25.0) and 25 other tissues See more
Orthologs

Genomic context

See DYNC1I2 in Genome Data Viewer
Location:
2q31.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (171687469..171750158)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (172543919..172606668)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene cytochrome b reductase 1 Neighboring gene ribosomal protein L21 pseudogene 38 Neighboring gene solute carrier family 25 member 12 Neighboring gene RNA, U6 small nuclear 182, pseudogene Neighboring gene uncharacterized LOC105373739

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with dynein, cytoplasmic 1, intermediate chain 2 (DYNC1I2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
capsid gag HIV-1 CA uncoating is delayed in the presence of ciliobrevin D, a specific inhibitor of dynein-mediated motor function, indicating that dynein is involved in CA uncoating in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9324, FLJ21089, FLJ90842, MGC104199, MGC111094

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based movement NAS
Non-traceable Author Statement
more info
PubMed 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytoplasmic dynein 1 intermediate chain 2
Names
DH IC-2
dynein intermediate chain 2, cytosolic
dynein, cytoplasmic, intermediate polypeptide 2
testis tissue sperm-binding protein Li 66n

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271785.2NP_001258714.1  cytoplasmic dynein 1 intermediate chain 2 isoform 1

    See identical proteins and their annotated locations for NP_001258714.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC068039, AK055491, AK096579
    Consensus CDS
    CCDS46450.1
    UniProtKB/Swiss-Prot
    Q13409
    UniProtKB/TrEMBL
    A0A140VKE9
    Related
    ENSP00000386415.1, ENST00000409773.5
    Conserved Domains (3) summary
    COG2319
    Location:329599
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:339377
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:135163
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  2. NM_001271786.2NP_001258715.1  cytoplasmic dynein 1 intermediate chain 2 isoform 2

    See identical proteins and their annotated locations for NP_001258715.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter and contains an additional internal region, compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AC068039, AK298561, BC091498, DA435365
    Consensus CDS
    CCDS63054.1
    UniProtKB/Swiss-Prot
    Q13409
    UniProtKB/TrEMBL
    B4DPZ3
    Related
    ENSP00000386522.3, ENST00000410079.7
    Conserved Domains (3) summary
    COG2319
    Location:321591
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:331369
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:127155
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  3. NM_001271787.2NP_001258716.1  cytoplasmic dynein 1 intermediate chain 2 isoform 2

    See identical proteins and their annotated locations for NP_001258716.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter and contains an additional internal region, compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AC064826, AC068039, AK316119
    Consensus CDS
    CCDS63054.1
    UniProtKB/Swiss-Prot
    Q13409
    Conserved Domains (3) summary
    COG2319
    Location:321591
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:331369
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:127155
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  4. NM_001271788.2NP_001258717.1  cytoplasmic dynein 1 intermediate chain 2 isoform 3

    See identical proteins and their annotated locations for NP_001258717.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1. Both variants 5 and 6 encode the same isoform (3).
    Source sequence(s)
    AC068039, BC091498, DA435365
    Consensus CDS
    CCDS63056.1
    UniProtKB/Swiss-Prot
    Q13409
    Related
    ENSP00000339430.4, ENST00000340296.8
    Conserved Domains (3) summary
    COG2319
    Location:303573
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:313351
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:109137
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  5. NM_001271789.2NP_001258718.1  cytoplasmic dynein 1 intermediate chain 2 isoform 3

    See identical proteins and their annotated locations for NP_001258718.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1. Both variants 5 and 6 encode the same isoform (3).
    Source sequence(s)
    AC064826, AC068039, AF250307
    Consensus CDS
    CCDS63056.1
    UniProtKB/Swiss-Prot
    Q13409
    Related
    ENSP00000386397.1, ENST00000409197.5
    Conserved Domains (3) summary
    COG2319
    Location:303573
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:313351
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:109137
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  6. NM_001271790.2NP_001258719.1  cytoplasmic dynein 1 intermediate chain 2 isoform 4

    See identical proteins and their annotated locations for NP_001258719.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1. Both variants 7 and 8 encode the same isoform (4).
    Source sequence(s)
    AC068039, AY037160, DA435365
    Consensus CDS
    CCDS63057.1
    UniProtKB/Swiss-Prot
    Q13409
    Related
    ENSP00000423339.1, ENST00000508530.5
    Conserved Domains (3) summary
    COG2319
    Location:303573
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:313351
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:109137
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  7. NM_001320882.2NP_001307811.1  cytoplasmic dynein 1 intermediate chain 2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1. Both variants 9 and 10 encode the same isoform (5).
    Source sequence(s)
    AC068039, AK096579, DA435365
    Consensus CDS
    CCDS82533.1
    UniProtKB/Swiss-Prot
    Q13409
    Conserved Domains (3) summary
    COG2319
    Location:323593
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:333371
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:129157
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  8. NM_001320883.2NP_001307812.1  cytoplasmic dynein 1 intermediate chain 2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1. Both variants 9 and 10 encode the same isoform (5).
    Source sequence(s)
    AC068039, AF250307, AK096579, BP355434
    Consensus CDS
    CCDS82533.1
    UniProtKB/Swiss-Prot
    Q13409
    Related
    ENSP00000386591.1, ENST00000409317.5
    Conserved Domains (3) summary
    COG2319
    Location:323593
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:333371
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:129157
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  9. NM_001320884.2NP_001307813.1  cytoplasmic dynein 1 intermediate chain 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1. Both variants 7 and 8 encode the same isoform (4).
    Source sequence(s)
    AC068039, AF250307, BP355434
    Consensus CDS
    CCDS63057.1
    UniProtKB/Swiss-Prot
    Q13409
    Conserved Domains (3) summary
    COG2319
    Location:303573
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:313351
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:109137
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  10. NM_001378.3NP_001369.1  cytoplasmic dynein 1 intermediate chain 2 isoform 1

    See identical proteins and their annotated locations for NP_001369.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC068039, AK055491, BC091498, DA435365
    Consensus CDS
    CCDS46450.1
    UniProtKB/Swiss-Prot
    Q13409
    UniProtKB/TrEMBL
    A0A140VKE9
    Related
    ENSP00000380308.3, ENST00000397119.7
    Conserved Domains (3) summary
    COG2319
    Location:329599
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:339377
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:135163
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  11. NM_001378455.1NP_001365384.1  cytoplasmic dynein 1 intermediate chain 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC064826, AC068039
  12. NM_001378456.1NP_001365385.1  cytoplasmic dynein 1 intermediate chain 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC064826, AC068039
    Related
    ENSP00000386886.1, ENST00000409453.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    171687469..171750158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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