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DYNC1I2 dynein cytoplasmic 1 intermediate chain 2 [ Homo sapiens (human) ]

Gene ID: 1781, updated on 6-Jan-2019

Summary

Official Symbol
DYNC1I2provided by HGNC
Official Full Name
dynein cytoplasmic 1 intermediate chain 2provided by HGNC
Primary source
HGNC:HGNC:2964
See related
Ensembl:ENSG00000077380 MIM:603331
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IC2; DIC74; DNCI2
Summary
This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in brain (RPKM 28.2), endometrium (RPKM 25.0) and 25 other tissues See more
Orthologs

Genomic context

See DYNC1I2 in Genome Data Viewer
Location:
2q31.1
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (171687409..171750158)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (172543919..172606668)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene cytochrome b reductase 1 Neighboring gene ribosomal protein L21 pseudogene 38 Neighboring gene solute carrier family 25 member 12 Neighboring gene RNA, U6 small nuclear 182, pseudogene Neighboring gene uncharacterized LOC105373739

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with dynein, cytoplasmic 1, intermediate chain 2 (DYNC1I2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
capsid gag HIV-1 CA uncoating is delayed in the presence of ciliobrevin D, a specific inhibitor of dynein-mediated motor function, indicating that dynein is involved in CA uncoating in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • AURKA Activation by TPX2, organism-specific biosystem (from REACTOME)
    AURKA Activation by TPX2, organism-specific biosystemTPX2 binds to aurora kinase A (AURKA) at centrosomes and promotes its activation by facilitating AURKA active conformation and autophosphorylation of the AURKA threonine residue T288 (Bayliss et al. ...
  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Anchoring of the basal body to the plasma membrane, organism-specific biosystem (from REACTOME)
    Anchoring of the basal body to the plasma membrane, organism-specific biosystemCilium biogenesis is initiated by the docking of basal bodies, a centriole-derived organelle, to the plasma membrane (reviewed in Reiter et al, 2012). The centriole consists of a multiprotein core su...
  • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
    Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
  • COPI-independent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-independent Golgi-to-ER retrograde traffic, organism-specific biosystemIn addition to the better characterized COPI-dependent retrograde Golgi-to-ER pathway, a second COPI-independent pathway has also been identified. This pathway is RAB6 dependent and transports cargo...
  • COPI-mediated anterograde transport, organism-specific biosystem (from REACTOME)
    COPI-mediated anterograde transport, organism-specific biosystemThe ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Centrosome maturation, organism-specific biosystem (from REACTOME)
    Centrosome maturation, organism-specific biosystemThe centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an ...
  • Cilium Assembly, organism-specific biosystem (from REACTOME)
    Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
  • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
    ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
  • G2/M Transition, organism-specific biosystem (from REACTOME)
    G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Loss of Nlp from mitotic centrosomes, organism-specific biosystem (from REACTOME)
    Loss of Nlp from mitotic centrosomes, organism-specific biosystemDuring interphase, Nlp interacts with gamma-tubulin ring complexes (gamma-TuRC), and is thought to contribute to the organization of interphase microtubules (Casenghi et al.,2003). Plk1 is activated...
  • Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystem (from REACTOME)
    Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystemIn addition to recruiting proteins and complexes necessary for increased microtubule nucleation, centrosomal maturation involves the loss of proteins involved in interphase microtubule organization ...
  • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
    MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
    Mitotic G2-G2/M phases, organism-specific biosystem
    Mitotic G2-G2/M phases
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystem (from REACTOME)
    Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystemThe mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centro...
  • Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystem (from REACTOME)
    Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystemThe kinase activity of PLK1 is required for cell cycle progression as PLK1 phosphorylates and regulates a number of cellular proteins during mitosis. Centrosomic AURKA (Aurora A kinase), catalyticall...
  • Salmonella infection, organism-specific biosystem (from KEGG)
    Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Salmonella infection, conserved biosystem (from KEGG)
    Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
    Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
  • Vasopressin-regulated water reabsorption, organism-specific biosystem (from KEGG)
    Vasopressin-regulated water reabsorption, organism-specific biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
  • Vasopressin-regulated water reabsorption, conserved biosystem (from KEGG)
    Vasopressin-regulated water reabsorption, conserved biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9324, FLJ21089, FLJ90842, MGC104199, MGC111094

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to ATP-dependent microtubule motor activity, plus-end-directed IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based movement NAS
Non-traceable Author Statement
more info
PubMed 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytoplasmic dynein 1 intermediate chain 2
Names
DH IC-2
dynein intermediate chain 2, cytosolic
dynein, cytoplasmic, intermediate polypeptide 2
testis tissue sperm-binding protein Li 66n

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271785.1NP_001258714.1  cytoplasmic dynein 1 intermediate chain 2 isoform 1

    See identical proteins and their annotated locations for NP_001258714.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC064826, AC068039, AK055491, AK096579
    Consensus CDS
    CCDS46450.1
    UniProtKB/Swiss-Prot
    Q13409
    UniProtKB/TrEMBL
    A0A140VKE9
    Related
    ENSP00000386415.1, ENST00000409773.5
    Conserved Domains (3) summary
    COG2319
    Location:329599
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:339377
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:135163
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  2. NM_001271786.1NP_001258715.1  cytoplasmic dynein 1 intermediate chain 2 isoform 2

    See identical proteins and their annotated locations for NP_001258715.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter and contains an additional internal region, compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AC068039, AK298561, BC091498, DA435365
    Consensus CDS
    CCDS63054.1
    UniProtKB/Swiss-Prot
    Q13409
    UniProtKB/TrEMBL
    B4DPZ3
    Related
    ENSP00000386522.3, ENST00000410079.7
    Conserved Domains (3) summary
    COG2319
    Location:321591
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:331369
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:127155
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  3. NM_001271787.1NP_001258716.1  cytoplasmic dynein 1 intermediate chain 2 isoform 2

    See identical proteins and their annotated locations for NP_001258716.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter and contains an additional internal region, compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AC064826, AC068039, AK316119
    Consensus CDS
    CCDS63054.1
    UniProtKB/Swiss-Prot
    Q13409
    Conserved Domains (3) summary
    COG2319
    Location:321591
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:331369
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:127155
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  4. NM_001271788.1NP_001258717.1  cytoplasmic dynein 1 intermediate chain 2 isoform 3

    See identical proteins and their annotated locations for NP_001258717.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1. Both variants 5 and 6 encode the same isoform (3).
    Source sequence(s)
    AC068039, BC091498, DA435365
    Consensus CDS
    CCDS63056.1
    UniProtKB/Swiss-Prot
    Q13409
    Related
    ENSP00000339430.4, ENST00000340296.8
    Conserved Domains (3) summary
    COG2319
    Location:303573
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:313351
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:109137
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  5. NM_001271789.1NP_001258718.1  cytoplasmic dynein 1 intermediate chain 2 isoform 3

    See identical proteins and their annotated locations for NP_001258718.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1. Both variants 5 and 6 encode the same isoform (3).
    Source sequence(s)
    AC064826, AC068039, AF250307
    Consensus CDS
    CCDS63056.1
    UniProtKB/Swiss-Prot
    Q13409
    Related
    ENSP00000386397.1, ENST00000409197.5
    Conserved Domains (3) summary
    COG2319
    Location:303573
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:313351
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:109137
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  6. NM_001271790.1NP_001258719.1  cytoplasmic dynein 1 intermediate chain 2 isoform 4

    See identical proteins and their annotated locations for NP_001258719.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1. Both variants 7 and 8 encode the same isoform (4).
    Source sequence(s)
    AC068039, AY037160, DA435365
    Consensus CDS
    CCDS63057.1
    UniProtKB/Swiss-Prot
    Q13409
    Related
    ENSP00000423339.1, ENST00000508530.5
    Conserved Domains (3) summary
    COG2319
    Location:303573
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:313351
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:109137
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  7. NM_001320882.1NP_001307811.1  cytoplasmic dynein 1 intermediate chain 2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1. Both variants 9 and 10 encode the same isoform (5).
    Source sequence(s)
    AC068039, AK096579, DA435365
    Consensus CDS
    CCDS82533.1
    UniProtKB/Swiss-Prot
    Q13409
    Conserved Domains (3) summary
    COG2319
    Location:323593
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:333371
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:129157
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  8. NM_001320883.1NP_001307812.1  cytoplasmic dynein 1 intermediate chain 2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1. Both variants 9 and 10 encode the same isoform (5).
    Source sequence(s)
    AC064826, AC068039, AF250307, AK096579, BP355434
    Consensus CDS
    CCDS82533.1
    UniProtKB/Swiss-Prot
    Q13409
    Related
    ENSP00000386591.1, ENST00000409317.5
    Conserved Domains (3) summary
    COG2319
    Location:323593
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:333371
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:129157
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  9. NM_001320884.1NP_001307813.1  cytoplasmic dynein 1 intermediate chain 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1. Both variants 7 and 8 encode the same isoform (4).
    Source sequence(s)
    AC064826, AC068039, AF250307, BP355434
    Consensus CDS
    CCDS63057.1
    UniProtKB/Swiss-Prot
    Q13409
    Conserved Domains (3) summary
    COG2319
    Location:303573
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:313351
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:109137
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  10. NM_001378.2NP_001369.1  cytoplasmic dynein 1 intermediate chain 2 isoform 1

    See identical proteins and their annotated locations for NP_001369.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC068039, AK055491, BC091498, DA435365
    Consensus CDS
    CCDS46450.1
    UniProtKB/Swiss-Prot
    Q13409
    UniProtKB/TrEMBL
    A0A140VKE9
    Related
    ENSP00000380308.3, ENST00000397119.7
    Conserved Domains (3) summary
    COG2319
    Location:329599
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:339377
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:135163
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    171687409..171750158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003525.2XP_016859014.1  cytoplasmic dynein 1 intermediate chain 2 isoform X1

    Conserved Domains (4) summary
    COG2319
    Location:323593
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:129157
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:333371
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:270592
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006712347.4XP_006712410.1  cytoplasmic dynein 1 intermediate chain 2 isoform X1

    See identical proteins and their annotated locations for XP_006712410.1

    Related
    ENSP00000386886.1, ENST00000409453.5
    Conserved Domains (4) summary
    COG2319
    Location:323593
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:129157
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:333371
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:270592
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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