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Dync1i2 dynein cytoplasmic 1 intermediate chain 2 [ Mus musculus (house mouse) ]

Gene ID: 13427, updated on 5-Jan-2023

Summary

Official Symbol
Dync1i2provided by MGI
Official Full Name
dynein cytoplasmic 1 intermediate chain 2provided by MGI
Primary source
MGI:MGI:107750
See related
Ensembl:ENSMUSG00000027012 AllianceGenome:MGI:107750
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dncic2; 3110079H08Rik
Summary
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in negative regulation of neuron projection development and transport along microtubule. Part of outer dynein arm. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; limb bud; and nose. Orthologous to human DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 64.5), CNS E14 (RPKM 54.3) and 20 other tissues See more
Orthologs
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Genomic context

See Dync1i2 in Genome Data Viewer
Location:
2 C2; 2 42.38 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (71041999..71093647)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (71211676..71263303)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cytochrome b reductase 1 Neighboring gene predicted gene, 39576 Neighboring gene solute carrier family 25 (mitochondrial carrier, Aralar), member 12 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene histone aminotransferase 1 Neighboring gene nuclear protein-NHP2-like protein pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of dynein complex ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
part_of outer dynein arm IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytoplasmic dynein 1 intermediate chain 2
Names
DH IC-2
dynein intermediate chain 2, cytosolic
dynein, cytoplasmic, intermediate chain 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198872.1NP_001185801.1  cytoplasmic dynein 1 intermediate chain 2 isoform 1

    See identical proteins and their annotated locations for NP_001185801.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1; also called 1a.D) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 6 encode the same protein.
    Source sequence(s)
    BQ174310, BY065048, GU992208
    UniProtKB/TrEMBL
    D6Q0F5
    Conserved Domains (4) summary
    COG2319
    Location:346616
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:152180
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:356394
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:397622
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001198873.1NP_001185802.1  cytoplasmic dynein 1 intermediate chain 2 isoform 2

    See identical proteins and their annotated locations for NP_001185802.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2; also called 1a.E) uses an alternate splice acceptor site in the 5' coding region, compared to variant 1. Variant 2 encodes a shorter isoform (2), compared to isoform 1. Variants 2 and 7 encode the same protein.
    Source sequence(s)
    BQ174310, BY065048, GU992209
    UniProtKB/TrEMBL
    D6Q0F6
    Conserved Domains (4) summary
    COG2319
    Location:341611
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:147175
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:351389
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:392617
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001198874.1NP_001185803.1  cytoplasmic dynein 1 intermediate chain 2 isoform 3

    See identical proteins and their annotated locations for NP_001185803.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3; also called 1a.B) lacks multiple exons in the 5' coding region, compared to variant 1. Variant 3 encodes a shorter isoform (3), compared to isoform 1.
    Source sequence(s)
    AK141837, BQ174310, BY065048
    Consensus CDS
    CCDS57175.1
    UniProtKB/TrEMBL
    Q3TPJ8
    Related
    ENSMUSP00000107770.2, ENSMUST00000112142.8
    Conserved Domains (3) summary
    COG2319
    Location:323593
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:333371
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:129157
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  4. NM_001198875.1NP_001185804.1  cytoplasmic dynein 1 intermediate chain 2 isoform 4

    See identical proteins and their annotated locations for NP_001185804.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4; also called 1a.F) lacks multiple exons in the 5' coding region, compared to variant 1. Variant 4 encodes a shorter isoform (4), compared to isoform 1.
    Source sequence(s)
    BQ174310, BY065048, GU992210
    UniProtKB/TrEMBL
    D6Q0F7
    Conserved Domains (3) summary
    COG2319
    Location:309579
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:319357
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:115143
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  5. NM_001198876.1NP_001185805.1  cytoplasmic dynein 1 intermediate chain 2 isoform 5

    See identical proteins and their annotated locations for NP_001185805.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5; also called 1a.C) lacks multiple exons in the 5' coding region, compared to variant 1. Variant 5 encodes a shorter isoform (5), compared to isoform 1. Variants 5 and 8 encode the same protein.
    Source sequence(s)
    AK164437, BQ174310, BY065048
    Consensus CDS
    CCDS16112.1
    UniProtKB/Swiss-Prot
    O88487, Q3TGH7
    UniProtKB/TrEMBL
    A0A8C6GMJ9, A2BFF7
    Related
    ENSMUSP00000107766.2, ENSMUST00000112138.8
    Conserved Domains (4) summary
    COG2319
    Location:303573
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:109137
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:313351
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:253572
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. NM_001198877.1NP_001185806.1  cytoplasmic dynein 1 intermediate chain 2 isoform 1

    See identical proteins and their annotated locations for NP_001185806.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6; also called 1b.D) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 6 encode the same protein (isoform 1).
    Source sequence(s)
    AK168730, BQ174310, BY226221, GU992211
    UniProtKB/Swiss-Prot
    O88487
    UniProtKB/TrEMBL
    D6Q0F5
    Conserved Domains (4) summary
    COG2319
    Location:346616
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:152180
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:356394
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:397622
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. NM_001198878.1NP_001185807.1  cytoplasmic dynein 1 intermediate chain 2 isoform 2

    See identical proteins and their annotated locations for NP_001185807.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7; also called 1b.E) differs in the 5' UTR and uses an alternate splice acceptor site in the 5' coding region, compared to variant 1. Variant 7 encodes a shorter isoform (2), compared to isoform 1. Variants 2 and 7 encode the same protein.
    Source sequence(s)
    AK164437, BQ174310, BY226221, GU992212
    UniProtKB/Swiss-Prot
    O88487
    UniProtKB/TrEMBL
    D6Q0F6
    Conserved Domains (4) summary
    COG2319
    Location:341611
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:147175
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:351389
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:392617
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. NM_001347173.1NP_001334102.1  cytoplasmic dynein 1 intermediate chain 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    BX284624, BX544878
    Consensus CDS
    CCDS84536.1
    UniProtKB/TrEMBL
    A0A8C6GN22, A2BFF9
    Related
    ENSMUSP00000107772.3, ENSMUST00000112144.9
    Conserved Domains (3) summary
    COG2319
    Location:329599
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:339377
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:135163
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  9. NM_010064.4NP_034194.1  cytoplasmic dynein 1 intermediate chain 2 isoform 5

    See identical proteins and their annotated locations for NP_034194.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8; also called 1b.C) differs in the 5' UTR and lacks multiple exons in the 5' coding region, compared to variant 1. Variant 8 encodes a shorter isoform (5), compared to isoform 1. Variants 5 and 8 encode the same protein.
    Source sequence(s)
    AK168730, BQ174310, BY226221, GU992210
    Consensus CDS
    CCDS16112.1
    UniProtKB/Swiss-Prot
    O88487, Q3TGH7
    UniProtKB/TrEMBL
    A0A8C6GMJ9, A2BFF7, D6Q0F7
    Related
    ENSMUSP00000080410.6, ENSMUST00000081710.12
    Conserved Domains (4) summary
    COG2319
    Location:303573
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:109137
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:313351
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:253572
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    71041999..71093647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315319.3XP_017170808.1  cytoplasmic dynein 1 intermediate chain 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C6GN22, A2BFF9
    Related
    ENSMUSP00000107768.2, ENSMUST00000112140.8
    Conserved Domains (3) summary
    COG2319
    Location:329599
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:339377
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:135163
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  2. XM_017315326.3XP_017170815.1  cytoplasmic dynein 1 intermediate chain 2 isoform X7

    UniProtKB/TrEMBL
    A2BFF8
    Related
    ENSMUSP00000107767.2, ENSMUST00000112139.8
    Conserved Domains (3) summary
    COG2319
    Location:303573
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:313351
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:109137
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  3. XM_017315324.3XP_017170813.1  cytoplasmic dynein 1 intermediate chain 2 isoform X4

    Conserved Domains (3) summary
    COG2319
    Location:323593
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:333371
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:129157
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  4. XM_006498678.4XP_006498741.1  cytoplasmic dynein 1 intermediate chain 2 isoform X5

    See identical proteins and their annotated locations for XP_006498741.1

    UniProtKB/TrEMBL
    D6Q0F7
    Conserved Domains (3) summary
    COG2319
    Location:309579
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:319357
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:115143
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  5. XM_006498677.3XP_006498740.1  cytoplasmic dynein 1 intermediate chain 2 isoform X3

    See identical proteins and their annotated locations for XP_006498740.1

    UniProtKB/TrEMBL
    Q3TPJ8
    Related
    ENSMUSP00000097605.4, ENSMUST00000100028.10
    Conserved Domains (3) summary
    COG2319
    Location:323593
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:333371
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:129157
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  6. XM_006498679.4XP_006498742.1  cytoplasmic dynein 1 intermediate chain 2 isoform X7

    UniProtKB/TrEMBL
    A2BFF8
    Conserved Domains (3) summary
    COG2319
    Location:303573
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:313351
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:109137
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  7. XM_006498676.3XP_006498739.1  cytoplasmic dynein 1 intermediate chain 2 isoform X2

    UniProtKB/TrEMBL
    A2BFF5
    Related
    ENSMUSP00000107764.2, ENSMUST00000112136.2
    Conserved Domains (3) summary
    COG2319
    Location:329599
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:339377
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:135163
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  8. XM_030247156.2XP_030103016.1  cytoplasmic dynein 1 intermediate chain 2 isoform X6

    Conserved Domains (3) summary
    COG2319
    Location:309579
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:319357
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:115143
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
  9. XM_030247151.2XP_030103011.1  cytoplasmic dynein 1 intermediate chain 2 isoform X4

    Conserved Domains (3) summary
    COG2319
    Location:323593
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:333371
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:129157
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

RNA

  1. XR_004938034.1 RNA Sequence

  2. XR_004938032.1 RNA Sequence

  3. XR_004938033.1 RNA Sequence

  4. XR_004938035.1 RNA Sequence