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egl-21 Carboxypeptidase E [ Caenorhabditis elegans ]

Gene ID: 177940, updated on 18-Sep-2024

Summary

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Official Symbol
egl-21
Official Full Name
Carboxypeptidase E
Primary source
WormBase:WBGene00001189
Locus tag
CELE_F01D4.4
See related
AllianceGenome:WB:WBGene00001189
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables carboxypeptidase activity. Involved in several processes, including acetylcholine secretion, neurotransmission; cellular response to carbon dioxide; and positive regulation of secretion. Located in axon; cytoplasmic vesicle; and neuronal cell body. Is expressed in nervous system and uv1. Human ortholog(s) of this gene implicated in carboxypeptidase N deficiency and type 2 diabetes mellitus. Orthologous to several human genes including CPE (carboxypeptidase E). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (10478442..10481844, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene glucuronosyltransferase Neighboring gene I-beta-1,3-N-acetylglucosaminyltransferase Neighboring gene pseudo Neighboring gene PHD-type domain-containing protein Neighboring gene Dedicator of cytokinesis protein 1 Neighboring gene Serine/threonine-protein phosphatase 2B catalytic subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RIC-7 promotes neuropeptide secretion. Hao Y, et al. PLoS Genet, 2012 Jan. PMID 22275875, Free PMC Article
  2. Processing of neuropeptide precursors in Caenorhabditis elegans. Husson SJ, et al. Commun Agric Appl Biol Sci, 2007. PMID 18018887
  3. The EGL-21 carboxypeptidase E facilitates acetylcholine release at Caenorhabditis elegans neuromuscular junctions. Jacob TC, et al. J Neurosci, 2003 Mar 15. PMID 12657671, Free PMC Article
  4. EGL-3 and EGL-21 are required to trigger nocifensive response of Caenorhabditis elegans to noxious heat. Nkambeu B, et al. Neuropeptides, 2019 Feb. PMID 30454862
  5. Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2. Edwards SL, et al. J Cell Biol, 2009 Sep 21. PMID 19797080, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our data has shown that thermal avoidance behavior of egl-3 and egl-21 mutants was significantly hampered compared to WT(N2) C. elegans.
    Title: EGL-3 and EGL-21 are required to trigger nocifensive response of Caenorhabditis elegans to noxious heat.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxypeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetylcholine secretion, neurotransmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to carbon dioxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of nematode pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuropeptide processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of acetylcholine secretion, neurotransmission IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of acetylcholine secretion, neurotransmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of defecation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of defecation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of digestive system process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of locomotion involved in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synaptic assembly at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of eating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of muscle contraction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Carboxypeptidase E
NP_501935.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10478442..10481844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069534.7 → NP_501935.1  Carboxypeptidase E [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501935.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17754
    Conserved Domains (2) summary
    cd03858
    Location:40 → 358
    M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
    cd11308
    Location:362 → 446
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O17754.1

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