Format

Send to

Choose Destination
See comment in PubMed Commons below
PLoS Genet. 2012 Jan;8(1):e1002464. doi: 10.1371/journal.pgen.1002464. Epub 2012 Jan 19.

RIC-7 promotes neuropeptide secretion.

Author information

1
Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

Abstract

Secretion of neurotransmitters and neuropeptides is mediated by exocytosis of distinct secretory organelles, synaptic vesicles (SVs) and dense core vesicles (DCVs) respectively. Relatively little is known about factors that differentially regulate SV and DCV secretion. Here we identify a novel protein RIC-7 that is required for neuropeptide secretion in Caenorhabditis elegans. The RIC-7 protein is expressed in all neurons and is localized to presynaptic terminals. Imaging, electrophysiology, and behavioral analysis of ric-7 mutants indicates that acetylcholine release occurs normally, while neuropeptide release is significantly decreased. These results suggest that RIC-7 promotes DCV-mediated secretion.

PMID:
22275875
PMCID:
PMC3261915
DOI:
10.1371/journal.pgen.1002464
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Support Center