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Mast2 microtubule associated serine/threonine kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 17776, updated on 12-May-2024

Summary

Official Symbol
Mast2provided by MGI
Official Full Name
microtubule associated serine/threonine kinase 2provided by MGI
Primary source
MGI:MGI:894676
See related
Ensembl:ENSMUSG00000003810 AllianceGenome:MGI:894676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mtssk; MAST205
Summary
Enables several functions, including ATP binding activity; magnesium ion binding activity; and microtubule binding activity. Involved in protein phosphorylation; regulation of interleukin-12 production; and spermatid differentiation. Located in microtubule cytoskeleton. Is expressed in central nervous system; lung epithelium; retina; and testis. Orthologous to human MAST2 (microtubule associated serine/threonine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 24.2), CNS E18 (RPKM 23.0) and 28 other tissues See more
Orthologs
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Genomic context

Location:
4 D1; 4 53.1 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116163957..116321420, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116306760..116464223, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11134 Neighboring gene STARR-seq mESC enhancer starr_11135 Neighboring gene LLP homolog, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E838 Neighboring gene phosphoinositide-3-kinase regulatory subunit 3 Neighboring gene STARR-seq mESC enhancer starr_11136 Neighboring gene BRCA1 associated RING domain 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_11138 Neighboring gene predicted gene, 52760 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:116180277-116180386 Neighboring gene STARR-seq mESC enhancer starr_11140 Neighboring gene IAP promoted placental gene Neighboring gene transmembrane protein 69

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0807

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spermatid differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
microtubule-associated serine/threonine-protein kinase 2
Names
microtubule associated testis specific serine/threonine protein kinase
NP_001036208.1
NP_001355990.1
NP_001355991.1
NP_032667.2
XP_006502897.1
XP_006502898.1
XP_006502899.1
XP_006502902.1
XP_030109157.1
XP_036019689.1
XP_036019690.1
XP_036019691.1
XP_036019692.1
XP_036019693.1
XP_036019694.1
XP_036019695.1
XP_036019696.1
XP_036019697.1
XP_036019698.1
XP_036019699.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042743.2NP_001036208.1  microtubule-associated serine/threonine-protein kinase 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC060703, BY597795, CB246117, CJ182836
    Consensus CDS
    CCDS38850.1
    UniProtKB/Swiss-Prot
    Q60592, Q6P9M1, Q8CHD1
    UniProtKB/TrEMBL
    B1AST7, E9Q1Q1
    Related
    ENSMUSP00000102093.3, ENSMUST00000106484.9
    Conserved Domains (4) summary
    smart00220
    Location:520793
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11101191
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:519798
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:202483
    DUF1908; Domain of unknown function (DUF1908)
  2. NM_001369061.1NP_001355990.1  microtubule-associated serine/threonine-protein kinase 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AL627394, AL669953, AL670603
    UniProtKB/Swiss-Prot
    Q60592, Q6P9M1, Q8CHD1
    Conserved Domains (3) summary
    cd00992
    Location:11101191
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:519798
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:202483
    DUF1908; Domain of unknown function (DUF1908)
  3. NM_001369062.1NP_001355991.1  microtubule-associated serine/threonine-protein kinase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL627394, AL669953, AL670603
    UniProtKB/Swiss-Prot
    Q60592, Q6P9M1, Q8CHD1
    Conserved Domains (3) summary
    cd00992
    Location:11031184
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:512791
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:202476
    DUF1908; Domain of unknown function (DUF1908)
  4. NM_008641.3NP_032667.2  microtubule-associated serine/threonine-protein kinase 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    BC060703, BU055783, BU610780, BU701350, BU706282, BY597795, CB246117, CF743521, CJ182836, CK633885, CN696803
    Consensus CDS
    CCDS38849.1
    UniProtKB/Swiss-Prot
    Q60592, Q6P9M1, Q8CHD1
    UniProtKB/TrEMBL
    B1AST8, E9QLW6
    Related
    ENSMUSP00000003908.6, ENSMUST00000003908.12
    Conserved Domains (4) summary
    smart00220
    Location:513786
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11031184
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:512791
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:202476
    DUF1908; Domain of unknown function (DUF1908)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    116163957..116321420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502836.5XP_006502899.1  microtubule-associated serine/threonine-protein kinase 2 isoform X5

    UniProtKB/TrEMBL
    A0A668KL31
    Conserved Domains (3) summary
    cd00992
    Location:9591040
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:368647
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:58332
    DUF1908; Domain of unknown function (DUF1908)
  2. XM_006502835.5XP_006502898.1  microtubule-associated serine/threonine-protein kinase 2 isoform X4

    UniProtKB/TrEMBL
    A0A668KL31
    Conserved Domains (3) summary
    cd00992
    Location:9661047
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:375654
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:58339
    DUF1908; Domain of unknown function (DUF1908)
  3. XM_030253297.2XP_030109157.1  microtubule-associated serine/threonine-protein kinase 2 isoform X10

    UniProtKB/TrEMBL
    A0A668KL31
    Conserved Domains (3) summary
    cd00992
    Location:810891
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:219498
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:1183
    DUF1908; Domain of unknown function (DUF1908)
  4. XM_006502834.3XP_006502897.1  microtubule-associated serine/threonine-protein kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A668KL31
    Related
    ENSMUSP00000159199.2, ENSMUST00000239177.2
    Conserved Domains (3) summary
    cd00992
    Location:10241105
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:433712
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:116397
    DUF1908; Domain of unknown function (DUF1908)
  5. XM_036163803.1XP_036019696.1  microtubule-associated serine/threonine-protein kinase 2 isoform X10

    UniProtKB/TrEMBL
    A0A668KL31
    Conserved Domains (3) summary
    cd00992
    Location:810891
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:219498
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:1183
    DUF1908; Domain of unknown function (DUF1908)
  6. XM_036163800.1XP_036019693.1  microtubule-associated serine/threonine-protein kinase 2 isoform X8

    UniProtKB/TrEMBL
    A0A668KL31
    Conserved Domains (3) summary
    cd00992
    Location:9521033
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:361640
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:51325
    DUF1908; Domain of unknown function (DUF1908)
  7. XM_036163797.1XP_036019690.1  microtubule-associated serine/threonine-protein kinase 2 isoform X3

    UniProtKB/TrEMBL
    A0A668KL31
    Conserved Domains (3) summary
    cd00992
    Location:10171098
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:426705
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:116390
    DUF1908; Domain of unknown function (DUF1908)
  8. XM_036163796.1XP_036019689.1  microtubule-associated serine/threonine-protein kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A668KL31
    Conserved Domains (3) summary
    cd00992
    Location:10171098
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:426705
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:116390
    DUF1908; Domain of unknown function (DUF1908)
  9. XM_036163802.1XP_036019695.1  microtubule-associated serine/threonine-protein kinase 2 isoform X10

    UniProtKB/TrEMBL
    A0A668KL31
    Conserved Domains (3) summary
    cd00992
    Location:810891
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:219498
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:1183
    DUF1908; Domain of unknown function (DUF1908)
  10. XM_036163798.1XP_036019691.1  microtubule-associated serine/threonine-protein kinase 2 isoform X6

    UniProtKB/TrEMBL
    A0A668KL31
    Conserved Domains (3) summary
    cd00992
    Location:9591040
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:368647
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:51332
    DUF1908; Domain of unknown function (DUF1908)
  11. XM_036163806.1XP_036019699.1  microtubule-associated serine/threonine-protein kinase 2 isoform X11

    UniProtKB/TrEMBL
    A0A668KL31
    Conserved Domains (3) summary
    cd00992
    Location:810891
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:219498
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:1183
    DUF1908; Domain of unknown function (DUF1908)
  12. XM_036163805.1XP_036019698.1  microtubule-associated serine/threonine-protein kinase 2 isoform X11

    UniProtKB/TrEMBL
    A0A668KL31
    Conserved Domains (3) summary
    cd00992
    Location:810891
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:219498
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:1183
    DUF1908; Domain of unknown function (DUF1908)
  13. XM_036163799.1XP_036019692.1  microtubule-associated serine/threonine-protein kinase 2 isoform X7

    UniProtKB/TrEMBL
    A0A668KL31
    Conserved Domains (3) summary
    cd00992
    Location:9591040
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:368647
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:51332
    DUF1908; Domain of unknown function (DUF1908)
  14. XM_036163801.1XP_036019694.1  microtubule-associated serine/threonine-protein kinase 2 isoform X9

    UniProtKB/TrEMBL
    A0A668KL31, A0A668KLF8
    Related
    ENSMUSP00000159270.2, ENSMUST00000239239.2
    Conserved Domains (3) summary
    cd00992
    Location:9521033
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:361640
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:51325
    DUF1908; Domain of unknown function (DUF1908)
  15. XM_036163804.1XP_036019697.1  microtubule-associated serine/threonine-protein kinase 2 isoform X10

    UniProtKB/TrEMBL
    A0A668KL31
    Conserved Domains (3) summary
    cd00992
    Location:810891
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:219498
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:1183
    DUF1908; Domain of unknown function (DUF1908)
  16. XM_006502839.1XP_006502902.1  microtubule-associated serine/threonine-protein kinase 2 isoform X12

    UniProtKB/TrEMBL
    Q9DBV8
    Conserved Domains (3) summary
    smart00133
    Location:231
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd00992
    Location:317398
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02163
    Location:347455
    Peptidase_M50; Peptidase family M50