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MAST2 microtubule associated serine/threonine kinase 2 [ Homo sapiens (human) ]

Gene ID: 23139, updated on 6-Sep-2022

Summary

Official Symbol
MAST2provided by HGNC
Official Full Name
microtubule associated serine/threonine kinase 2provided by HGNC
Primary source
HGNC:HGNC:19035
See related
Ensembl:ENSG00000086015 MIM:612257; AllianceGenome:HGNC:19035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTSSK; MAST205
Summary
Enables phosphatase binding activity. Predicted to be involved in several processes, including peptidyl-serine phosphorylation; regulation of interleukin-12 production; and spermatid differentiation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 25.4), heart (RPKM 11.8) and 23 other tissues See more
Orthologs
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Genomic context

See MAST2 in Genome Data Viewer
Location:
1p34.1
Exon count:
37
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (45803612..46036122)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (45680810..45913311)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46269284..46501794)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378693 Neighboring gene ribosomal protein L6 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 10352 Neighboring gene uncharacterized LOC105378694 Neighboring gene translation machinery associated 16 homolog pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 5403 Neighboring gene P3R3URF-PIK3R3 readthrough Neighboring gene uncharacterized LOC124904171 Neighboring gene phosphoinositide-3-kinase regulatory subunit 3 Neighboring gene uncharacterized LOC101929626

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39200, KIAA0807

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of interleukin-12 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatid differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
microtubule-associated serine/threonine-protein kinase 2
Names
microtubule associated testis specific serine/threonine protein kinase
NP_001306174.1
NP_001311249.1
NP_001311250.1
NP_055927.2
XP_005270712.1
XP_005270713.1
XP_006710540.1
XP_011539361.1
XP_011539363.1
XP_011539364.1
XP_011539365.1
XP_011539366.1
XP_011539369.1
XP_011539370.1
XP_011539371.1
XP_016856241.1
XP_016856242.1
XP_016856244.1
XP_047306052.1
XP_047306061.1
XP_047306067.1
XP_047306072.1
XP_047306077.1
XP_047306078.1
XP_047306079.1
XP_047306085.1
XP_047306086.1
XP_047306094.1
XP_047306097.1
XP_047306098.1
XP_047306101.1
XP_047306105.1
XP_047306106.1
XP_047306109.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319245.2NP_001306174.1  microtubule-associated serine/threonine-protein kinase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB047005, AL358075, AL603882, BC065499
    UniProtKB/Swiss-Prot
    Q6P0Q8
    Conserved Domains (4) summary
    smart00220
    Location:512785
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11051186
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:511790
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:201475
    DUF1908; Domain of unknown function (DUF1908)
  2. NM_001324320.2NP_001311249.1  microtubule-associated serine/threonine-protein kinase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL358075, AL603882, AL603888, AL645480
    Conserved Domains (4) summary
    smart00220
    Location:519792
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11121193
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:518797
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:201482
    DUF1908; Domain of unknown function (DUF1908)
  3. NM_001324321.2NP_001311250.1  microtubule-associated serine/threonine-protein kinase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL358075, AL603888, AL645480
    Conserved Domains (4) summary
    smart00220
    Location:358631
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9511032
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:357636
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:40321
    DUF1908; Domain of unknown function (DUF1908)
  4. NM_015112.3NP_055927.2  microtubule-associated serine/threonine-protein kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_055927.2

    Status: VALIDATED

    Source sequence(s)
    AB047005, AL540100, AL603882, BC065499, CN297081
    Consensus CDS
    CCDS41326.1
    UniProtKB/Swiss-Prot
    Q6P0Q8, Q9BYE8
    Related
    ENSP00000354671.2, ENST00000361297.7
    Conserved Domains (4) summary
    smart00220
    Location:512785
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11051186
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:511790
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:201475
    DUF1908; Domain of unknown function (DUF1908)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    45803612..46036122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541059.3XP_011539361.1  microtubule-associated serine/threonine-protein kinase 2 isoform X1

    Conserved Domains (4) summary
    smart00220
    Location:584857
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11771258
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:583862
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:266547
    DUF1908; Domain of unknown function (DUF1908)
  2. XM_011541069.3XP_011539371.1  microtubule-associated serine/threonine-protein kinase 2 isoform X24

    Conserved Domains (4) summary
    smart00220
    Location:584857
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11771258
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:583862
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:266547
    DUF1908; Domain of unknown function (DUF1908)
  3. XM_011541061.3XP_011539363.1  microtubule-associated serine/threonine-protein kinase 2 isoform X2

    Conserved Domains (4) summary
    smart00220
    Location:584857
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11771258
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:583862
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:266547
    DUF1908; Domain of unknown function (DUF1908)
  4. XM_047450141.1XP_047306097.1  microtubule-associated serine/threonine-protein kinase 2 isoform X25

  5. XM_011541062.3XP_011539364.1  microtubule-associated serine/threonine-protein kinase 2 isoform X3

    Conserved Domains (4) summary
    smart00220
    Location:577850
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11701251
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:576855
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:266540
    DUF1908; Domain of unknown function (DUF1908)
  6. XM_047450142.1XP_047306098.1  microtubule-associated serine/threonine-protein kinase 2 isoform X26

  7. XM_047450096.1XP_047306052.1  microtubule-associated serine/threonine-protein kinase 2 isoform X4

  8. XM_047450145.1XP_047306101.1  microtubule-associated serine/threonine-protein kinase 2 isoform X27

  9. XM_047450111.1XP_047306067.1  microtubule-associated serine/threonine-protein kinase 2 isoform X8

  10. XM_047450149.1XP_047306105.1  microtubule-associated serine/threonine-protein kinase 2 isoform X28

  11. XM_047450150.1XP_047306106.1  microtubule-associated serine/threonine-protein kinase 2 isoform X29

  12. XM_047450153.1XP_047306109.1  microtubule-associated serine/threonine-protein kinase 2 isoform X30

  13. XM_047450105.1XP_047306061.1  microtubule-associated serine/threonine-protein kinase 2 isoform X7

  14. XM_047450121.1XP_047306077.1  microtubule-associated serine/threonine-protein kinase 2 isoform X10

  15. XM_047450123.1XP_047306079.1  microtubule-associated serine/threonine-protein kinase 2 isoform X12

  16. XM_047450129.1XP_047306085.1  microtubule-associated serine/threonine-protein kinase 2 isoform X13

  17. XM_011541064.3XP_011539366.1  microtubule-associated serine/threonine-protein kinase 2 isoform X6

    Conserved Domains (4) summary
    smart00220
    Location:531804
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11241205
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:530809
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:213494
    DUF1908; Domain of unknown function (DUF1908)
  18. XM_047450116.1XP_047306072.1  microtubule-associated serine/threonine-protein kinase 2 isoform X9

  19. XM_047450122.1XP_047306078.1  microtubule-associated serine/threonine-protein kinase 2 isoform X11

  20. XM_011541063.2XP_011539365.1  microtubule-associated serine/threonine-protein kinase 2 isoform X5

    Conserved Domains (4) summary
    smart00220
    Location:534807
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11271208
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:533812
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:216497
    DUF1908; Domain of unknown function (DUF1908)
  21. XM_017000752.2XP_016856241.1  microtubule-associated serine/threonine-protein kinase 2 isoform X14

  22. XM_017000755.2XP_016856244.1  microtubule-associated serine/threonine-protein kinase 2 isoform X19

  23. XM_047450130.1XP_047306086.1  microtubule-associated serine/threonine-protein kinase 2 isoform X17

  24. XM_005270655.4XP_005270712.1  microtubule-associated serine/threonine-protein kinase 2 isoform X15

    Conserved Domains (4) summary
    smart00220
    Location:434707
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:10271108
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:433712
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:116397
    DUF1908; Domain of unknown function (DUF1908)
  25. XM_006710477.4XP_006710540.1  microtubule-associated serine/threonine-protein kinase 2 isoform X20

    UniProtKB/TrEMBL
    A0A669KBJ4
    Related
    ENSP00000501318.1, ENST00000674079.1
    Conserved Domains (4) summary
    smart00220
    Location:369642
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9621043
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:368647
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:51332
    DUF1908; Domain of unknown function (DUF1908)
  26. XM_017000753.2XP_016856242.1  microtubule-associated serine/threonine-protein kinase 2 isoform X18

  27. XM_047450138.1XP_047306094.1  microtubule-associated serine/threonine-protein kinase 2 isoform X23

  28. XM_005270656.6XP_005270713.1  microtubule-associated serine/threonine-protein kinase 2 isoform X16

    Conserved Domains (4) summary
    smart00220
    Location:425698
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:10181099
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:424703
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:107388
    DUF1908; Domain of unknown function (DUF1908)
  29. XM_011541067.3XP_011539369.1  microtubule-associated serine/threonine-protein kinase 2 isoform X21

    Conserved Domains (4) summary
    smart00220
    Location:357630
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9501031
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:356635
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:39320
    DUF1908; Domain of unknown function (DUF1908)
  30. XM_011541068.2XP_011539370.1  microtubule-associated serine/threonine-protein kinase 2 isoform X22

    Conserved Domains (4) summary
    smart00220
    Location:350623
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9431024
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:349628
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:39313
    DUF1908; Domain of unknown function (DUF1908)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    45680810..45913311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)