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Sik1 salt inducible kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 17691, updated on 12-May-2024

Summary

Official Symbol
Sik1provided by MGI
Official Full Name
salt inducible kinase 1provided by MGI
Primary source
MGI:MGI:104754
See related
Ensembl:ENSMUSG00000024042 AllianceGenome:MGI:104754
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Msk; Sik; Sik-1; Hrt-20; Snf1lk
Summary
Enables several functions, including ATP binding activity; cAMP response element binding protein binding activity; and enzyme binding activity. Involved in several processes, including anoikis; entrainment of circadian clock by photoperiod; and regulation of cellular biosynthetic process. Acts upstream of or within regulation of cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 30. Orthologous to human SIK1 (salt inducible kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 31.0), spleen adult (RPKM 26.0) and 27 other tissues See more
Orthologs
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Genomic context

See Sik1 in Genome Data Viewer
Location:
17 B1; 17 17.25 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32063222..32074808, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31844248..31855804, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41563 Neighboring gene STARR-seq mESC enhancer starr_42358 Neighboring gene predicted gene, 41564 Neighboring gene STARR-positive B cell enhancer ABC_E5589 Neighboring gene STARR-positive B cell enhancer ABC_E11794 Neighboring gene predicted gene, 41565 Neighboring gene predicted gene, 30509

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables cAMP response element binding protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of CREB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of CREB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of myotube differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase SIK1
Names
Probable serine/threonine protein kinase SNF1LK (HRT-20) (Myocardial SNF1-like kinase)
SNF1-like kinase
myocardial SNF1-like kinase
salt-inducible protein kinase 1
serine/threonine-protein kinase SNF1-like kinase 1
serine/threonine-protein kinase SNF1LK
NP_034961.2
XP_036016256.1
XP_036016257.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010831.3NP_034961.2  serine/threonine-protein kinase SIK1

    See identical proteins and their annotated locations for NP_034961.2

    Status: VALIDATED

    Source sequence(s)
    AC166654, AK141817
    Consensus CDS
    CCDS37552.1
    UniProtKB/Swiss-Prot
    Q3UR46, Q60670
    UniProtKB/TrEMBL
    Q571I6
    Related
    ENSMUSP00000024839.5, ENSMUST00000024839.6
    Conserved Domains (3) summary
    smart00220
    Location:27278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14408
    Location:300349
    UBA_SIK1; UBA domain found in salt-inducible kinase 1 (SIK1)
    cd14071
    Location:26278
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    32063222..32074808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160364.1XP_036016257.1  serine/threonine-protein kinase SIK1 isoform X2

    UniProtKB/TrEMBL
    Q571I6
    Conserved Domains (2) summary
    cd14408
    Location:208257
    UBA_SIK1; UBA domain found in salt-inducible kinase 1 (SIK1)
    cl21453
    Location:1186
    PKc_like; Protein Kinases, catalytic domain
  2. XM_036160363.1XP_036016256.1  serine/threonine-protein kinase SIK1 isoform X1

    UniProtKB/TrEMBL
    Q571I6
    Conserved Domains (2) summary
    cd14408
    Location:223272
    UBA_SIK1; UBA domain found in salt-inducible kinase 1 (SIK1)
    cl21453
    Location:1201
    PKc_like; Protein Kinases, catalytic domain