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SIK1 salt inducible kinase 1 [ Homo sapiens (human) ]

Gene ID: 150094, updated on 13-Mar-2020

Summary

Official Symbol
SIK1provided by HGNC
Official Full Name
salt inducible kinase 1provided by HGNC
Primary source
HGNC:HGNC:11142
See related
Ensembl:ENSG00000142178 MIM:605705
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSK; SIK; SIK-1; SIK1B; SNF1LK
Summary
This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transduction pathways. A mutation in this gene is associated with early infantile epileptic encephalopathy 30. [provided by RefSeq, Nov 2016]
Expression
Ubiquitous expression in adrenal (RPKM 28.1), liver (RPKM 25.6) and 25 other tissues See more
Orthologs

Genomic context

See SIK1 in Genome Data Viewer
Location:
21q22.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (43414483..43427131, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (44834395..44847002, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377137 Neighboring gene uncharacterized LOC107987301 Neighboring gene uncharacterized LOC107987302 Neighboring gene SIK1-LINC00319 intergenic CAGE-defined high expression enhancer Neighboring gene long intergenic non-protein coding RNA 319

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of salt-inducible kinase 1 (SIK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cAMP response element binding protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cardiac muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of CREB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of myotube differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase SIK1
Names
Probable serine/threonine-protein kinase SIK1B
SNF1-like kinase
Salt-inducible kinase 1B
myocardial SNF1-like kinase
salt-inducible protein kinase 1
serine/threonine-protein kinase SNF1-like kinase 1
serine/threonine-protein kinase SNF1LK
NP_775490.2
XP_011527776.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052009.1 RefSeqGene

    Range
    5002..17650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_173354.5NP_775490.2  serine/threonine-protein kinase SIK1

    See identical proteins and their annotated locations for NP_775490.2

    Status: REVIEWED

    Source sequence(s)
    AB047786, AP001046, HY008464
    Consensus CDS
    CCDS33575.1
    UniProtKB/Swiss-Prot
    P57059
    Related
    ENSP00000270162.6, ENST00000270162.8
    Conserved Domains (3) summary
    smart00220
    Location:27278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14408
    Location:300349
    UBA_SIK1; UBA domain found in salt-inducible kinase 1 (SIK1)
    cd14071
    Location:26278
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    43414483..43427131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529474.2XP_011527776.1  serine/threonine-protein kinase SIK1 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:27278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14071
    Location:26278
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases
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