U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

bath-42 BTB and MATH domain-containing protein 42 [ Caenorhabditis elegans ]

Gene ID: 176152, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
bath-42
Official Full Name
BTB and MATH domain-containing protein 42
Primary source
WormBase:WBGene00016803
Locus tag
CELE_C50C3.8
See related
AllianceGenome:WB:WBGene00016803
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to be active in cytoplasm and nucleus. Is expressed in intestine; nervous system; non-striated muscle; and seam cell. Orthologous to human SPOP (speckle type BTB/POZ protein). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See bath-42 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (8161455..8163383, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Autophagy-related protein 13 homolog Neighboring gene Inositol polyphosphate 5-phosphatase Neighboring gene Pre-mRNA-splicing factor 8 homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The BTB-MATH protein BATH-42 interacts with RIC-3 to regulate maturation of nicotinic acetylcholine receptors. Shteingauz A, et al. J Cell Sci, 2009 Mar 15. PMID 19223395
  2. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Xu L, et al. Nature, 2003 Sep 18. PMID 13679922
  3. A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode. Tsushima H, et al. PLoS One, 2013. PMID 23424658, Free PMC Article
  4. Integrating interactome, phenome, and transcriptome mapping data for the C. elegans germline. Walhout AJ, et al. Curr Biol, 2002 Nov 19. PMID 12445390
  5. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
BTB and MATH domain-containing protein 42
NP_498784.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8161455..8163383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066383.7 → NP_498784.1  BTB and MATH domain-containing protein 42 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498784.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34371
    Conserved Domains (4) summary
    smart00225
    Location:220 → 319
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cd00121
    Location:47 → 174
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
    cd14734
    Location:319 → 380
    SPOP_C; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00651
    Location:212 → 315
    BTB; BTB/POZ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34371.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous