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gst-6 putative glutathione S-transferase 6 [ Caenorhabditis elegans ]

Gene ID: 173841, updated on 18-Sep-2024

Summary

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Official Symbol
gst-6
Official Full Name
putative glutathione S-transferase 6
Primary source
WormBase:WBGene00001754
Locus tag
CELE_F11G11.3
See related
AllianceGenome:WB:WBGene00001754
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glutathione transferase activity. Involved in innate immune response. Orthologous to human HPGDS (hematopoietic prostaglandin D synthase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003280.10 (4879891..4881105)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Ovule protein Neighboring gene arginine kinase Neighboring gene putative glutathione S-transferase 7 Neighboring gene putative glutathione S-transferase 8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tris(1,3-dichloro-2-propyl) phosphate accelerated the aging process induced by the 4-hydroxynon-2-enal response to reactive oxidative species in Caenorhabditis elegans. Wang C, et al. Environ Pollut, 2019 Mar. PMID 31159140
  2. Insecticidal activity and mechanism of cinnamaldehyde in C. elegans. Lu L, et al. Fitoterapia, 2020 Oct. PMID 32681860
  3. Ageing and oxidants in the nematode Caenorhabditis elegans. Gems D. SEB Exp Biol Ser, 2009. PMID 19418991
  4. Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal. Ayyadevara S, et al. Mech Ageing Dev, 2007 Feb. PMID 17157356, Free PMC Article
  5. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response HEP PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
putative glutathione S-transferase 6
NP_494882.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    4879891..4881105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062481.10 → NP_494882.2  putative glutathione S-transferase 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494882.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91252
    Conserved Domains (3) summary
    PTZ00057
    Location:6 → 203
    PTZ00057; glutathione s-transferase; Provisional
    cd03192
    Location:84 → 188
    GST_C_Sigma_like; C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases
    cd03039
    Location:4 → 73
    GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91252.2

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