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KCNG3 potassium voltage-gated channel modifier subfamily G member 3 [ Homo sapiens (human) ]

Gene ID: 170850, updated on 13-Mar-2020

Summary

Official Symbol
KCNG3provided by HGNC
Official Full Name
potassium voltage-gated channel modifier subfamily G member 3provided by HGNC
Primary source
HGNC:HGNC:18306
See related
Ensembl:ENSG00000171126 MIM:606767
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KV6.3; KV10.1
Summary
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See KCNG3 in Genome Data Viewer
Location:
2p21
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (42442017..42493982, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (42669157..42721237, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 7A2 like Neighboring gene uncharacterized LOC105374537 Neighboring gene voltage dependent anion channel 1 pseudogene 13 Neighboring gene ribosomal protein S13 pseudogene 3 Neighboring gene metastasis associated 1 family member 3 Neighboring gene uncharacterized LOC105374555 Neighboring gene Sharpr-MPRA regulatory region 10188

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
delayed rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
potassium voltage-gated channel subfamily G member 3
Names
potassium channel, voltage gated modifier subfamily G, member 3
potassium voltage-gated channel, subfamily G, member 3
voltage-gated potassium channel 6.3
voltage-gated potassium channel Kv10.1
voltage-gated potassium channel subunit Kv10.1
voltage-gated potassium channel subunit Kv6.3
voltage-gated potassium channel subunit Kv6.4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133329.6NP_579875.1  potassium voltage-gated channel subfamily G member 3 isoform 1

    See identical proteins and their annotated locations for NP_579875.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as Kv10.1b, encodes the longer isoform (1).
    Source sequence(s)
    AC025750, AF348982, BC071558
    Consensus CDS
    CCDS1809.1
    UniProtKB/Swiss-Prot
    Q8TAE7
    Related
    ENSP00000304127.1, ENST00000306078.2
    Conserved Domains (2) summary
    pfam00520
    Location:219420
    Ion_trans; Ion transport protein
    cl02518
    Location:11111
    BTB; BTB/POZ domain
  2. NM_172344.3NP_758847.1  potassium voltage-gated channel subfamily G member 3 isoform 2

    See identical proteins and their annotated locations for NP_758847.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as Kv10.1a, lacks an alternate in-frame segment in the coding region, as compared to variant 1. It encodes isoform (2) that lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC025750, AF348982, AF454547, BC071558
    Consensus CDS
    CCDS42674.1
    UniProtKB/Swiss-Prot
    Q8TAE7
    Related
    ENSP00000378424.4, ENST00000394973.4
    Conserved Domains (2) summary
    pfam00520
    Location:202409
    Ion_trans; Ion transport protein
    cl02518
    Location:11111
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    42442017..42493982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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