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Kcng3 potassium voltage-gated channel, subfamily G, member 3 [ Mus musculus (house mouse) ]

Gene ID: 225030, updated on 18-Sep-2024

Summary

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Official Symbol
Kcng3provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily G, member 3provided by MGI
Primary source
MGI:MGI:2663923
See related
Ensembl:ENSMUSG00000045053 AllianceGenome:MGI:2663923
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KV6.3; Kv10.1a; Kv10.1b
Summary
Predicted to enable delayed rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within potassium ion transport. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be integral component of membrane. Is expressed in diencephalon lateral wall mantle layer; hypothalamus mantle layer; lung; and midbrain mantle layer. Orthologous to human KCNG3 (potassium voltage-gated channel modifier subfamily G member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 1.2), bladder adult (RPKM 1.1) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Kcng3 in Genome Data Viewer
Location:
17 E4; 17 53.64 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (83881452..83939595, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (83574023..83631995, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2501 Neighboring gene predicted gene, 41635 Neighboring gene predicted gene, 34801 Neighboring gene STARR-positive B cell enhancer ABC_E9967 Neighboring gene STARR-seq mESC enhancer starr_43388 Neighboring gene STARR-seq mESC enhancer starr_43389 Neighboring gene STARR-seq mESC enhancer starr_43390 Neighboring gene STARR-seq mESC enhancer starr_43391 Neighboring gene STARR-seq mESC enhancer starr_43393 Neighboring gene metastasis associated 3 Neighboring gene predicted gene, 46597 Neighboring gene STARR-seq mESC enhancer starr_43408 Neighboring gene predicted gene, 41637

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. De novo expression of Kv6.3 contributes to changes in vascular smooth muscle cell excitability in a hypertensive mice strain. Moreno-Domínguez A, et al. J Physiol, 2009 Feb 1. PMID 19074965, Free PMC Article
  2. Modification of Kv2.1 K+ currents by the silent Kv10 subunits. Vega-Saenz de Miera EC. Brain Res Mol Brain Res, 2004 Apr 7. PMID 15046870
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables potassium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily G member 3
Names
voltage-gated potassium channel subunit Kv10.1
voltage-gated potassium channel subunit Kv6.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153512.1 → NP_705732.1  potassium voltage-gated channel subfamily G member 3

    See identical proteins and their annotated locations for NP_705732.1

    Status: PROVISIONAL

    Source sequence(s)
    AF454552
    Consensus CDS
    CCDS28996.1
    UniProtKB/Swiss-Prot
    P59053
    Related
    ENSMUSP00000054910.2, ENSMUST00000051482.2
    Conserved Domains (4) summary
    smart00225
    Location:11 → 119
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:216 → 417
    Ion_trans; Ion transport protein
    pfam07885
    Location:360 → 405
    Ion_trans_2; Ion channel
    cl02518
    Location:11 → 111
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    83881452..83939595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524200.5 → XP_006524263.1  potassium voltage-gated channel subfamily G member 3 isoform X1

    See identical proteins and their annotated locations for XP_006524263.1

    UniProtKB/Swiss-Prot
    P59053
    Related
    ENSMUSP00000157121.2, ENSMUST00000234613.2
    Conserved Domains (2) summary
    cd18422
    Location:11 → 122
    BTB_POZ_KCNG3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 3 (KCNG3)
    pfam00520
    Location:202 → 406
    Ion_trans; Ion transport protein

  2. XM_036160577.1 → XP_036016470.1  potassium voltage-gated channel subfamily G member 3 isoform X2

    Conserved Domains (1) summary
    cl38908
    Location:11 → 122
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

RNA

  1. XR_004939523.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59053.1 GenPept UniProtKB/Swiss-Prot:P59053

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