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Lrrn3 leucine rich repeat protein 3, neuronal [ Mus musculus (house mouse) ]

Gene ID: 16981, updated on 2-Jul-2024

Summary

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Official Symbol
Lrrn3provided by MGI
Official Full Name
leucine rich repeat protein 3, neuronalprovided by MGI
Primary source
MGI:MGI:106036
See related
Ensembl:ENSMUSG00000036295 AllianceGenome:MGI:106036
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NLRR-3
Summary
Acts upstream of or within positive regulation of synapse assembly. Predicted to be located in plasma membrane. Predicted to be part of clathrin adaptor complex. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; peripheral nervous system ganglion; respiratory system; and sensory organ. Orthologous to human LRRN3 (leucine rich repeat neuronal 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 20.4), whole brain E14.5 (RPKM 13.9) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Lrrn3 in Genome Data Viewer
Location:
12 B1; 12 18.94 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (41501667..41536056, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (41451668..41486057, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_31983 Neighboring gene STARR-seq mESC enhancer starr_31984 Neighboring gene predicted gene, 51974 Neighboring gene STARR-seq mESC enhancer starr_31985 Neighboring gene STARR-seq mESC enhancer starr_31987 Neighboring gene STARR-seq mESC enhancer starr_31989 Neighboring gene predicted gene, 25497 Neighboring gene STARR-seq mESC enhancer starr_31990 Neighboring gene STARR-seq mESC enhancer starr_31991 Neighboring gene predicted gene, 40412 Neighboring gene STARR-seq mESC enhancer starr_31992 Neighboring gene STARR-seq mESC enhancer starr_31994 Neighboring gene STARR-seq mESC enhancer starr_31995 Neighboring gene STARR-seq mESC enhancer starr_31996 Neighboring gene STARR-seq mESC enhancer starr_31997 Neighboring gene predicted gene, 46348

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and expression of a novel gene for a protein with leucine-rich repeats in the developing mouse nervous system. Taniguchi H, et al. Brain Res Mol Brain Res, 1996 Feb. PMID 9011764
  2. Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression. Fukamachi K, et al. Biochem Biophys Res Commun, 2001 Sep 14. PMID 11549284
  3. Slitrk6 expression profile in the mouse embryo and its relationship to that of Nlrr3. Aruga J. Gene Expr Patterns, 2003 Dec. PMID 14643680
  4. The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts. Haines BP, et al. Dev Biol, 2005 May 15. PMID 15893969
  5. Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Homma S, et al. Gene Expr Patterns, 2009 Jan. PMID 18848646

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Analysis of NLRR-3 expression revealed regulated expression in the neural system in developing ganglia and motor neurons.
    Title: The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of clathrin adaptor complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat neuronal protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271708.1 → NP_001258637.1  leucine-rich repeat neuronal protein 3 precursor

    See identical proteins and their annotated locations for NP_001258637.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC167364, BC069041, CJ058856
    Consensus CDS
    CCDS25896.1
    UniProtKB/Swiss-Prot
    P97860, Q8CBC6
    Conserved Domains (8) summary
    smart00370
    Location:139 → 160
    LRR; Leucine-rich repeats, outliers
    smart00013
    Location:28 → 72
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:368 → 419
    LRRCT; Leucine rich repeat C-terminal domain
    pfam07679
    Location:429 → 513
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:94 → 117
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:526 → 593
    fn3; Fibronectin type III domain
    pfam13855
    Location:93 → 152
    LRR_8; Leucine rich repeat
    cl11960
    Location:440 → 513
    Ig; Immunoglobulin domain

  2. NM_001271709.1 → NP_001258638.1  leucine-rich repeat neuronal protein 3 precursor

    See identical proteins and their annotated locations for NP_001258638.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC167364, BC069041, CJ061095
    Consensus CDS
    CCDS25896.1
    UniProtKB/Swiss-Prot
    P97860, Q8CBC6
    Conserved Domains (8) summary
    smart00370
    Location:139 → 160
    LRR; Leucine-rich repeats, outliers
    smart00013
    Location:28 → 72
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:368 → 419
    LRRCT; Leucine rich repeat C-terminal domain
    pfam07679
    Location:429 → 513
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:94 → 117
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:526 → 593
    fn3; Fibronectin type III domain
    pfam13855
    Location:93 → 152
    LRR_8; Leucine rich repeat
    cl11960
    Location:440 → 513
    Ig; Immunoglobulin domain

  3. NM_010733.3 → NP_034863.1  leucine-rich repeat neuronal protein 3 precursor

    See identical proteins and their annotated locations for NP_034863.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC167364, BC069041
    Consensus CDS
    CCDS25896.1
    UniProtKB/Swiss-Prot
    P97860, Q8CBC6
    Related
    ENSMUSP00000043818.5, ENSMUST00000043884.6
    Conserved Domains (8) summary
    smart00370
    Location:139 → 160
    LRR; Leucine-rich repeats, outliers
    smart00013
    Location:28 → 72
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:368 → 419
    LRRCT; Leucine rich repeat C-terminal domain
    pfam07679
    Location:429 → 513
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:94 → 117
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:526 → 593
    fn3; Fibronectin type III domain
    pfam13855
    Location:93 → 152
    LRR_8; Leucine rich repeat
    cl11960
    Location:440 → 513
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    41501667..41536056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CBC6.1 GenPept UniProtKB/Swiss-Prot:Q8CBC6

Gene LinkOut

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