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IDO2 indoleamine 2,3-dioxygenase 2 [ Homo sapiens (human) ]

Gene ID: 169355, updated on 21-Dec-2019

Summary

Official Symbol
IDO2provided by HGNC
Official Full Name
indoleamine 2,3-dioxygenase 2provided by HGNC
Primary source
HGNC:HGNC:27269
See related
Ensembl:ENSG00000188676 MIM:612129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INDOL1
Summary
Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]
Expression
Biased expression in placenta (RPKM 9.5), liver (RPKM 2.8) and 3 other tissues See more
Orthologs

Genomic context

See IDO2 in Genome Data Viewer
Location:
8p11.21
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (39934955..40016391)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (39792474..39873910)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 2 Neighboring gene polo like kinase 4 pseudogene Neighboring gene indoleamine 2,3-dioxygenase 1 Neighboring gene nuclear transcription factor Y subunit beta pseudogene Neighboring gene HNF4 motif-containing MPRA enhancer 150 Neighboring gene uncharacterized LOC105379385 Neighboring gene long intergenic non-protein coding RNA 2866

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heme binding IEA
Inferred from Electronic Annotation
more info
 
indoleamine 2,3-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
indoleamine 2,3-dioxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
indoleamine 2,3-dioxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
tryptophan 2,3-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
'de novo' NAD biosynthetic process from tryptophan IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
tryptophan catabolic process TAS
Traceable Author Statement
more info
 
tryptophan catabolic process to kynurenine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tryptophan catabolic process to kynurenine IDA
Inferred from Direct Assay
more info
PubMed 
tryptophan catabolic process to kynurenine IEA
Inferred from Electronic Annotation
more info
 
tryptophan catabolic process to kynurenine ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
indoleamine 2,3-dioxygenase 2
Names
IDO-2
indoleamine 2,3-dioxygenase-like 1 protein
indoleamine 2,3-dioxygenase-like protein 1
indoleamine-pyrrole 2,3 dioxygenase-like 1
indoleamine-pyrrole 2,3-dioxygenase-like protein 1
NP_919270.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194294.2NP_919270.2  indoleamine 2,3-dioxygenase 2

    Status: VALIDATED

    Source sequence(s)
    AC087518, AK128691, EF052681
    Consensus CDS
    CCDS6114.2
    UniProtKB/Swiss-Prot
    Q6ZQW0
    Related
    ENSP00000443432.1, ENST00000502986.2
    Conserved Domains (1) summary
    pfam01231
    Location:28414
    IDO; Indoleamine 2,3-dioxygenase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    39934955..40016391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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