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Arhgef1 Rho guanine nucleotide exchange factor 1 [ Mus musculus (house mouse) ]

Gene ID: 16801, updated on 12-May-2024

Summary

Official Symbol
Arhgef1provided by MGI
Official Full Name
Rho guanine nucleotide exchange factor 1provided by MGI
Primary source
MGI:MGI:1353510
See related
Ensembl:ENSMUSG00000040940 AllianceGenome:MGI:1353510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lsc; Lbcl2
Summary
Predicted to enable G protein-coupled receptor binding activity; GTPase activator activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of cell death. Predicted to be located in cytosol and plasma membrane. Is expressed in brain and heart. Human ortholog(s) of this gene implicated in immunodeficiency 62. Orthologous to human ARHGEF1 (Rho guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 202.0), spleen adult (RPKM 157.1) and 26 other tissues See more
Orthologs
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Genomic context

See Arhgef1 in Genome Data Viewer
Location:
7 A3; 7 13.52 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24601762..24626019)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24902986..24926594)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25669584-25669693 Neighboring gene ribosomal protein S19 Neighboring gene STARR-positive B cell enhancer ABC_E10428 Neighboring gene STARR-positive B cell enhancer ABC_E1723 Neighboring gene CD79A antigen (immunoglobulin-associated alpha) Neighboring gene CapStarr-seq enhancers MGSCv37_chr7:25692211-25692364 and MGSCv37_chr7:25692403-25692604 Neighboring gene ETS repressor factor like Neighboring gene predicted gene, 36809

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 1
Names
Rho guanine nucleotide exchange factor (GEF) 1
lbc's second cousin
lymphoid blast crisis-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130150.2NP_001123622.1  rho guanine nucleotide exchange factor 1 isoform a

    See identical proteins and their annotated locations for NP_001123622.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC161441
    Consensus CDS
    CCDS52142.1
    UniProtKB/TrEMBL
    Q6KAM6
    Related
    ENSMUSP00000096280.5, ENSMUST00000098683.11
    Conserved Domains (4) summary
    cd08755
    Location:50242
    RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
    smart00325
    Location:478662
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PRK14086
    Location:275451
    dnaA; chromosomal replication initiator protein DnaA
    cd14679
    Location:696820
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
  2. NM_001130151.2NP_001123623.1  rho guanine nucleotide exchange factor 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the mid coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a. Variants 2 and 6-8 all encode the same isoform (b).
    Source sequence(s)
    AC161441
    Consensus CDS
    CCDS52140.1
    UniProtKB/TrEMBL
    E9PUF7, Q6KAM6
    Related
    ENSMUSP00000113771.2, ENSMUST00000117796.8
    Conserved Domains (4) summary
    cd08755
    Location:50242
    RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
    smart00325
    Location:475659
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03247
    Location:277458
    PHA03247; large tegument protein UL36; Provisional
    cd14679
    Location:693817
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
  3. NM_001130152.2NP_001123624.1  rho guanine nucleotide exchange factor 1 isoform c

    See identical proteins and their annotated locations for NP_001123624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and uses an alternate in-frame splice site and lacks two alternate in-frame exons in the mid coding region, compared to variant 1. The resulting isoform (c) is shorter than isoform a. Variants 3, 4, and 9 all encode the same isoform (c).
    Source sequence(s)
    AC161441
    Consensus CDS
    CCDS52141.1
    UniProtKB/Swiss-Prot
    O89074, Q3T9Q7, Q61210, Q80YE8, Q80YE9, Q91VL3
    UniProtKB/TrEMBL
    Q6KAM6
    Related
    ENSMUSP00000113366.2, ENSMUST00000117419.8
    Conserved Domains (4) summary
    pfam05887
    Location:304409
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    cd08755
    Location:50242
    RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
    smart00325
    Location:419603
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd14679
    Location:637761
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
  4. NM_001130153.2NP_001123625.1  rho guanine nucleotide exchange factor 1 isoform c

    See identical proteins and their annotated locations for NP_001123625.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site and lacks two alternate in-frame exons in the mid coding region, compared to variant 1. The resulting isoform (c) is shorter than isoform a. Variants 3, 4, and 9 all encode the same isoform (c).
    Source sequence(s)
    AC161441
    Consensus CDS
    CCDS52141.1
    UniProtKB/Swiss-Prot
    O89074, Q3T9Q7, Q61210, Q80YE8, Q80YE9, Q91VL3
    UniProtKB/TrEMBL
    Q6KAM6
    Related
    ENSMUSP00000046469.10, ENSMUST00000047873.16
    Conserved Domains (4) summary
    pfam05887
    Location:304409
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    cd08755
    Location:50242
    RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
    smart00325
    Location:419603
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd14679
    Location:637761
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
  5. NM_001412640.1NP_001399569.1  rho guanine nucleotide exchange factor 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC161441
    UniProtKB/TrEMBL
    E9PUF7
  6. NM_001412641.1NP_001399570.1  rho guanine nucleotide exchange factor 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC161441
    UniProtKB/TrEMBL
    E9PUF7
  7. NM_001412642.1NP_001399571.1  rho guanine nucleotide exchange factor 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC161441
    UniProtKB/TrEMBL
    E9PUF7
  8. NM_001412643.1NP_001399572.1  rho guanine nucleotide exchange factor 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC161441
    UniProtKB/Swiss-Prot
    O89074, Q3T9Q7, Q61210, Q80YE8, Q80YE9, Q91VL3
  9. NM_001412644.1NP_001399573.1  rho guanine nucleotide exchange factor 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC161441
  10. NM_001412645.1NP_001399574.1  rho guanine nucleotide exchange factor 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC161441
    Related
    ENSMUST00000145783.8
  11. NM_001412646.1NP_001399575.1  rho guanine nucleotide exchange factor 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC161441
  12. NM_001412647.1NP_001399576.1  rho guanine nucleotide exchange factor 1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC161441
  13. NM_001412648.1NP_001399577.1  rho guanine nucleotide exchange factor 1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC161441
  14. NM_001412649.1NP_001399578.1  rho guanine nucleotide exchange factor 1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC161441
  15. NM_008488.3NP_032514.1  rho guanine nucleotide exchange factor 1 isoform d

    See identical proteins and their annotated locations for NP_032514.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons in the mid coding region, compared to variant 1. The resulting isoform (d) is shorter than isoform a. Variants 5 and 10 both encode the same isoform (d).
    Source sequence(s)
    AC161441
    Consensus CDS
    CCDS85239.1
    UniProtKB/TrEMBL
    Q6KAM6
    Related
    ENSMUSP00000146314.2, ENSMUST00000206508.2
    Conserved Domains (4) summary
    pfam05887
    Location:303408
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    cd08755
    Location:50242
    RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
    smart00325
    Location:418602
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd14679
    Location:636760
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

RNA

  1. NR_182017.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC161441
  2. NR_182018.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC161441

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    24601762..24626019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152721.1XP_036008614.1  rho guanine nucleotide exchange factor 1 isoform X1

    UniProtKB/TrEMBL
    Q6KAM6
    Conserved Domains (4) summary
    cd08755
    Location:50242
    RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
    smart00325
    Location:479663
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03247
    Location:277462
    PHA03247; large tegument protein UL36; Provisional
    cd14679
    Location:697821
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
  2. XM_017322003.1XP_017177492.1  rho guanine nucleotide exchange factor 1 isoform X1

    UniProtKB/TrEMBL
    Q6KAM6
    Conserved Domains (4) summary
    cd08755
    Location:50242
    RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
    smart00325
    Location:479663
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03247
    Location:277462
    PHA03247; large tegument protein UL36; Provisional
    cd14679
    Location:697821
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
  3. XM_030242173.1XP_030098033.1  rho guanine nucleotide exchange factor 1 isoform X2

    UniProtKB/TrEMBL
    Q6KAM6
    Conserved Domains (4) summary
    cd08755
    Location:50242
    RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
    smart00325
    Location:478662
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PRK14086
    Location:275451
    dnaA; chromosomal replication initiator protein DnaA
    cd14679
    Location:696820
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
  4. XM_006539565.4XP_006539628.1  rho guanine nucleotide exchange factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006539628.1

    UniProtKB/TrEMBL
    Q6KAM6
    Conserved Domains (4) summary
    cd08755
    Location:50242
    RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
    smart00325
    Location:479663
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03247
    Location:277462
    PHA03247; large tegument protein UL36; Provisional
    cd14679
    Location:697821
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

RNA

  1. XR_004934023.1 RNA Sequence