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NIM1K NIM1 serine/threonine protein kinase [ Homo sapiens (human) ]

Gene ID: 167359, updated on 5-Mar-2024

Summary

Official Symbol
NIM1Kprovided by HGNC
Official Full Name
NIM1 serine/threonine protein kinaseprovided by HGNC
Primary source
HGNC:HGNC:28646
See related
Ensembl:ENSG00000177453 AllianceGenome:HGNC:28646
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIM1
Summary
Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in protein phosphorylation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 4.6), lung (RPKM 0.6) and 3 other tissues See more
Orthologs
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Genomic context

See NIM1K in Genome Data Viewer
Location:
5p12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (43192225..43280850)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (43445120..43533685)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (43192327..43280952)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506639 Neighboring gene uncharacterized LOC124900972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15990 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:43121535-43122103 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:43122104-43122671 Neighboring gene zinc finger protein 131 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:43192643-43193352 Neighboring gene spermine synthase pseudogene Neighboring gene tubulin alpha pseudogene 14 Neighboring gene Sharpr-MPRA regulatory region 4627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22535 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA synthase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22537 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:43313910-43314426 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:43314427-43314941 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:43315036-43316235 Neighboring gene CRISPRi-validated cis-regulatory element chr5.1234 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:43335752-43336951 Neighboring gene 60S acidic ribosomal protein P1-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ZNF131

Clone Names

  • MGC42105

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase NIM1
NP_699192.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153361.4NP_699192.1  serine/threonine-protein kinase NIM1

    See identical proteins and their annotated locations for NP_699192.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript.
    Source sequence(s)
    AC106800, BC036422, DA778478
    Consensus CDS
    CCDS3943.1
    UniProtKB/Swiss-Prot
    B3KVM1, Q8IY84
    Related
    ENSP00000313572.2, ENST00000326035.6
    Conserved Domains (2) summary
    smart00220
    Location:74325
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14075
    Location:71325
    STKc_NIM1; Catalytic domain of the Serine/Threonine Kinase, NIM1

RNA

  1. NR_072980.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC106800, AK122985, BC036422

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    43192225..43280850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    43445120..43533685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)