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NIM1K NIM1 serine/threonine protein kinase [ Homo sapiens (human) ]

Gene ID: 167359, updated on 25-Nov-2021

Summary

Official Symbol
NIM1Kprovided by HGNC
Official Full Name
NIM1 serine/threonine protein kinaseprovided by HGNC
Primary source
HGNC:HGNC:28646
See related
Ensembl:ENSG00000177453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIM1
Expression
Biased expression in brain (RPKM 4.6), lung (RPKM 0.6) and 3 other tissues See more
Orthologs
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Genomic context

See NIM1K in Genome Data Viewer
Location:
5p12
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (43192225..43280850)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (43192327..43280952)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506639 Neighboring gene Sharpr-MPRA regulatory region 15399 Neighboring gene zinc finger protein 131 Neighboring gene spermine synthase pseudogene Neighboring gene tubulin alpha pseudogene 14 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA synthase 1 Neighboring gene CRISPRi-validated cis-regulatory element chr5.1234

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ZNF131

Homology

Clone Names

  • MGC42105

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase NIM1
NP_699192.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153361.4NP_699192.1  serine/threonine-protein kinase NIM1

    See identical proteins and their annotated locations for NP_699192.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript.
    Source sequence(s)
    AC106800, BC036422, DA778478
    Consensus CDS
    CCDS3943.1
    UniProtKB/Swiss-Prot
    Q8IY84
    Related
    ENSP00000313572.2, ENST00000326035.6
    Conserved Domains (2) summary
    smart00220
    Location:74325
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14075
    Location:71325
    STKc_NIM1; Catalytic domain of the Serine/Threonine Kinase, NIM1

RNA

  1. NR_072980.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC106800, AK122985, BC036422

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    43192225..43280850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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