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ZNF131 zinc finger protein 131 [ Homo sapiens (human) ]

Gene ID: 7690, updated on 12-Oct-2019

Summary

Official Symbol
ZNF131provided by HGNC
Official Full Name
zinc finger protein 131provided by HGNC
Primary source
HGNC:HGNC:12915
See related
Ensembl:ENSG00000172262 MIM:604073
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZBTB35; pHZ-10
Expression
Ubiquitous expression in testis (RPKM 10.2), bone marrow (RPKM 5.2) and 25 other tissues See more
Orthologs

Genomic context

See ZNF131 in Genome Data Viewer
Location:
5p12
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (43120914..43176324)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (43120985..43176351)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC648987 Neighboring gene uncharacterized LOC100132356 Neighboring gene uncharacterized LOC100506639 Neighboring gene spermine synthase pseudogene Neighboring gene NIM1 serine/threonine protein kinase Neighboring gene tubulin alpha 3e pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 131
Names
zinc finger and BTB domain containing 35
zinc finger protein 131 (clone pHZ-10)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297548.2NP_001284477.1  zinc finger protein 131 isoform 1

    See identical proteins and their annotated locations for NP_001284477.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS78005.1
    UniProtKB/Swiss-Prot
    P52739
    Related
    ENSP00000426504.1, ENST00000509156.5
    Conserved Domains (6) summary
    smart00225
    Location:35122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:262444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24122
    BTB; BTB/POZ domain
    pfam13465
    Location:342367
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001330704.2NP_001317633.1  zinc finger protein 131 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC106800
  3. NM_001330705.1NP_001317634.1  zinc finger protein 131 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC106800
  4. NM_001330706.2NP_001317635.1  zinc finger protein 131 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS43313.1
    UniProtKB/TrEMBL
    A0A024R087
  5. NM_001330707.2NP_001317636.1  zinc finger protein 131 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS78005.1
    UniProtKB/Swiss-Prot
    P52739
    Conserved Domains (6) summary
    smart00225
    Location:35122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:262444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24122
    BTB; BTB/POZ domain
    pfam13465
    Location:342367
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001330708.2NP_001317637.1  zinc finger protein 131 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS78005.1
    UniProtKB/Swiss-Prot
    P52739
    Conserved Domains (6) summary
    smart00225
    Location:35122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:262444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24122
    BTB; BTB/POZ domain
    pfam13465
    Location:342367
    zf-H2C2_2; Zinc-finger double domain
  7. NM_001330709.2NP_001317638.1  zinc finger protein 131 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC106800
  8. NM_001330710.2NP_001317639.1  zinc finger protein 131 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC106800
  9. NM_001330711.1NP_001317640.1  zinc finger protein 131 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS43313.1
    UniProtKB/TrEMBL
    A0A024R087
  10. NM_001330712.1NP_001317641.1  zinc finger protein 131 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS78005.1
    UniProtKB/Swiss-Prot
    P52739
    Conserved Domains (6) summary
    smart00225
    Location:35122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:262444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24122
    BTB; BTB/POZ domain
    pfam13465
    Location:342367
    zf-H2C2_2; Zinc-finger double domain
  11. NM_001330713.2NP_001317642.1  zinc finger protein 131 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS43313.1
    UniProtKB/TrEMBL
    A0A024R087
    Related
    ENSP00000423945.1, ENST00000505606.6
  12. NM_001330714.2NP_001317643.1  zinc finger protein 131 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS78005.1
    UniProtKB/Swiss-Prot
    P52739
    Conserved Domains (6) summary
    smart00225
    Location:35122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:262444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24122
    BTB; BTB/POZ domain
    pfam13465
    Location:342367
    zf-H2C2_2; Zinc-finger double domain
  13. NM_001330715.2NP_001317644.1  zinc finger protein 131 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS43313.1
    UniProtKB/TrEMBL
    A0A024R087
  14. NM_001330716.2NP_001317645.1  zinc finger protein 131 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC106800
  15. NM_001330717.2NP_001317646.1  zinc finger protein 131 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC106800
    UniProtKB/Swiss-Prot
    P52739
    Conserved Domains (4) summary
    COG5048
    Location:167331
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:177198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:309326
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:229254
    zf-H2C2_2; Zinc-finger double domain
  16. NM_003432.3NP_003423.1  zinc finger protein 131 isoform 2

    See identical proteins and their annotated locations for NP_003423.1

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS43313.1
    UniProtKB/TrEMBL
    A0A024R087
    Related
    ENSP00000305804.4, ENST00000306938.8
    Conserved Domains (6) summary
    smart00225
    Location:35122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:246410
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:256277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:388405
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24122
    BTB; BTB/POZ domain
    pfam13465
    Location:308333
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    43120914..43176324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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