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Krt8 keratin 8 [ Mus musculus (house mouse) ]

Gene ID: 16691, updated on 31-Jan-2023

Summary

Official Symbol
Krt8provided by MGI
Official Full Name
keratin 8provided by MGI
Primary source
MGI:MGI:96705
See related
Ensembl:ENSMUSG00000049382 AllianceGenome:MGI:96705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K8; Card2; EndoA; Krt2-8; Krt-2.8
Summary
Predicted to enable scaffold protein binding activity. Acts upstream of or within several processes, including cell differentiation involved in embryonic placenta development; cell surface receptor signaling pathway; and hepatocyte apoptotic process. Located in several cellular components, including Z disc; apicolateral plasma membrane; and sarcolemma. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in liver cirrhosis. Orthologous to human KRT8 (keratin 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 1701.0), large intestine adult (RPKM 1411.0) and 6 other tissues See more
Orthologs
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Genomic context

See Krt8 in Genome Data Viewer
Location:
15 F2; 15 57.2 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101905146..101912777, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101996711..102004342, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene keratin 79 Neighboring gene keratin 78 Neighboring gene predicted gene, 36026 Neighboring gene predicted gene, 41404

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC118110

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in costamere ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of dystrophin-associated glycoprotein complex ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in intermediate filament ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in keratin filament ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
keratin, type II cytoskeletal 8
Names
CK-8
cytokeratin endo A
cytokeratin-8
keratin complex 2, basic, gene 8
type-II keratin Kb8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031170.2NP_112447.2  keratin, type II cytoskeletal 8

    See identical proteins and their annotated locations for NP_112447.2

    Status: VALIDATED

    Source sequence(s)
    AK145777
    Consensus CDS
    CCDS27868.1
    UniProtKB/Swiss-Prot
    P11679, Q61519
    Related
    ENSMUSP00000023952.9, ENSMUST00000023952.10
    Conserved Domains (3) summary
    pfam00038
    Location:96407
    Filament; Intermediate filament protein
    pfam16208
    Location:6993
    Keratin_2_head; Keratin type II head
    cl24005
    Location:288347
    DUF2570; Protein of unknown function (DUF2570)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    101905146..101912777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)