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Krt16 keratin 16 [ Mus musculus (house mouse) ]

Gene ID: 16666, updated on 9-Mar-2023

Summary

Official Symbol
Krt16provided by MGI
Official Full Name
keratin 16provided by MGI
Primary source
MGI:MGI:96690
See related
Ensembl:ENSMUSG00000053797 AllianceGenome:MGI:96690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K16; CK-16; Krt1-16
Summary
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The encoded protein is a cytokeratin and acts as an innate immune system effector, promoting the inflammatory response upon breach of the skin barrier. Defects in this gene are a cause of pachyonychia congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Biased expression in stomach adult (RPKM 8.3), limb E14.5 (RPKM 3.4) and 5 other tissues See more
Orthologs
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Genomic context

See Krt16 in Genome Data Viewer
Location:
11; 11 D
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100136917..100139728, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100246091..100248902, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene type I keratin KA11P Neighboring gene transcription elongation factor B (SIII), polypeptide 2 pseudogene Neighboring gene keratin 17 Neighboring gene keratin 42

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC124148

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in aging ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment of skin barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hair cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intermediate filament cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in keratinization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in keratinocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in keratinocyte migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cornified envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
keratin, type I cytoskeletal 16
Names
cytokeratin-16
keratin complex 1, acidic, gene 16
keratin intermediate filament 16a
keratin intermediate filament 16b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313958.1NP_001300887.1  keratin, type I cytoskeletal 16 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF053235, AK137631
    UniProtKB/Swiss-Prot
    Q9Z2K1
    UniProtKB/TrEMBL
    Q3ZAW8
    Conserved Domains (1) summary
    pfam00038
    Location:112420
    Filament; Intermediate filament protein
  2. NM_008470.1NP_032496.1  keratin, type I cytoskeletal 16 isoform 2

    See identical proteins and their annotated locations for NP_032496.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AF053235
    Consensus CDS
    CCDS25414.1
    UniProtKB/Swiss-Prot
    Q9Z2K1
    UniProtKB/TrEMBL
    Q3SYP5
    Related
    ENSMUSP00000007280.8, ENSMUST00000007280.9
    Conserved Domains (1) summary
    pfam00038
    Location:112420
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100136917..100139728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)