Krt16 keratin 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt16provided by MGI
Official Full Name: keratin 16provided by MGI
Primary source: MGI:MGI:96690
See related: Ensembl:ENSMUSG00000053797 AllianceGenome:MGI:96690
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K16; CK-16; Krt1-16
Summary: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The encoded protein is a cytokeratin and acts as an innate immune system effector, promoting the inflammatory response upon breach of the skin barrier. Defects in this gene are a cause of pachyonychia congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression: Biased expression in stomach adult (RPKM 8.3), limb E14.5 (RPKM 3.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 63.44 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (100136917..100139728, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100246091..100248902, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study identified iRHOM2 as a novel regulator of K16 in humans and mice, with important implications for palmoplantar keratodermas, wound healing, inflammatory skin disease and cancers.
Title: Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16.
we show that the loss of Krt16 function in mice causes the development of prominent calluses on the plantar side of front and hind paws, which significantly compromise mobility.
Title: Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders.
Long-term alteration in the expression of keratins 6 and 16 is seen in the epidermis of mice after chronic UVB exposure.
Title: Long-term alteration in the expression of keratins 6 and 16 in the epidermis of mice after chronic UVB exposure.
Keratin 6 and keratin 16 may play a role in wrinkle formation.
Title: Keratin alterations could be an early event of wrinkle formation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G16019 (e-PCR)
- UniSTS:78871

Krt1-16 (e-PCR), detects polymorphism
- UniSTS:265260

NoName (e-PCR)
- UniSTS:484914

AI324768 (e-PCR)
- UniSTS:180314

Krt16 (e-PCR), detects polymorphism
- UniSTS:547450

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of skin barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hair cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intermediate filament cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinization	IDA Inferred from Direct Assay more info	PubMed
involved_in keratinocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in keratinocyte migration	IDA Inferred from Direct Assay more info	PubMed
involved_in morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in intermediate filament	IDA Inferred from Direct Assay more info	PubMed
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: keratin, type I cytoskeletal 16

Names: cytokeratin-16; keratin complex 1, acidic, gene 16; keratin intermediate filament 16a; keratin intermediate filament 16b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313958.2 → NP_001300887.1 keratin, type I cytoskeletal 16 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL590873

UniProtKB/TrEMBL

Q3ZAW8, Q9EQD6

Conserved Domains (1) summary

pfam00038
Location:112 → 420

Filament; Intermediate filament protein
NM_008470.2 → NP_032496.1 keratin, type I cytoskeletal 16 isoform 2

See identical proteins and their annotated locations for NP_032496.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.

Source sequence(s)

AL590873

Consensus CDS

CCDS25414.1

UniProtKB/Swiss-Prot

Q9Z2K1

UniProtKB/TrEMBL

Q3SYP5, Q9EQD7

Related

ENSMUSP00000007280.8, ENSMUST00000007280.9

Conserved Domains (1) summary

pfam00038
Location:112 → 420

Filament; Intermediate filament protein