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KRT16 keratin 16 [ Homo sapiens (human) ]

Gene ID: 3868, updated on 5-Aug-2018

Summary

Official Symbol
KRT16provided by HGNC
Official Full Name
keratin 16provided by HGNC
Primary source
HGNC:HGNC:6423
See related
Ensembl:ENSG00000186832 MIM:148067; Vega:OTTHUMG00000133495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K16; PC1; CK16; K1CP; NEPPK; FNEPPK; KRT16A
Summary
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 209.9) and esophagus (RPKM 198.8) See more
Orthologs

Genomic context

See KRT16 in Genome Data Viewer
Location:
17q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (41609778..41612827, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39766030..39769079, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 9 Neighboring gene keratin 14 Neighboring gene keratin 17 Neighboring gene keratin 42 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Keratinization, organism-specific biosystem (from REACTOME)
    Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
aging IDA
Inferred from Direct Assay
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cornification TAS
Traceable Author Statement
more info
 
cytoskeleton organization NAS
Non-traceable Author Statement
more info
PubMed 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
establishment of skin barrier ISS
Inferred from Sequence or Structural Similarity
more info
 
hair cycle IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
intermediate filament cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
keratinization ISS
Inferred from Sequence or Structural Similarity
more info
 
keratinization TAS
Traceable Author Statement
more info
 
keratinocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
keratinocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
 
morphogenesis of an epithelium ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
intermediate filament NAS
Non-traceable Author Statement
more info
PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
keratin, type I cytoskeletal 16
Names
cytokeratin 16
focal non-epidermolytic palmoplantar keratoderma
keratin 16, type I

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008301.1 RefSeqGene

    Range
    5001..8050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005557.3NP_005548.2  keratin, type I cytoskeletal 16

    See identical proteins and their annotated locations for NP_005548.2

    Status: REVIEWED

    Source sequence(s)
    AK290853, BC039169, DC394235
    Consensus CDS
    CCDS11401.1
    UniProtKB/Swiss-Prot
    P08779
    Related
    ENSP00000301653.3, OTTHUMP00000164740, ENST00000301653.8, OTTHUMT00000257408
    Conserved Domains (2) summary
    pfam00038
    Location:116427
    Filament; Intermediate filament protein
    cl14876
    Location:239327
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    41609778..41612827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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