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TLE5 TLE family member 5, transcriptional modulator [ Homo sapiens (human) ]

Gene ID: 166, updated on 19-Feb-2019

Summary

Official Symbol
TLE5provided by HGNC
Official Full Name
TLE family member 5, transcriptional modulatorprovided by HGNC
Primary source
HGNC:HGNC:307
See related
Ensembl:ENSG00000104964 MIM:600188
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AES; GRG; ESP1; GRG5; AES-1; AES-2; Grg-5
Summary
The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 135.6), spleen (RPKM 116.8) and 25 other tissues See more
Orthologs

Genomic context

See TLE5 in Genome Data Viewer
Location:
19p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (3052910..3063107, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3052908..3062964, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene TLE family member 6, subcortical maternal complex member Neighboring gene TLE family member 2, transcriptional corepressor Neighboring gene uncharacterized LOC105372242 Neighboring gene G protein subunit alpha 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of amino-terminal enhancer of split (AES) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed
Knockdown of amino-terminal enhancer of split (AES) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
repressing transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
amino-terminal enhancer of split
Names
gp130-associated protein GAM
groucho-related protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029870.1 RefSeqGene

    Range
    5001..15057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130.5NP_001121.2  amino-terminal enhancer of split isoform b

    See identical proteins and their annotated locations for NP_001121.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AF269289, AK094591, BM550097, BM908356, N23852
    Consensus CDS
    CCDS12102.1
    UniProtKB/Swiss-Prot
    Q08117
    UniProtKB/TrEMBL
    Q8WY48
    Related
    ENSP00000317537.3, ENST00000327141.8
    Conserved Domains (1) summary
    pfam03920
    Location:2132
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  2. NM_198969.1NP_945320.1  amino-terminal enhancer of split isoform a

    See identical proteins and their annotated locations for NP_945320.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF269289, AK094591, BG913049, N23852
    Consensus CDS
    CCDS12101.1
    UniProtKB/Swiss-Prot
    Q08117
    UniProtKB/TrEMBL
    Q8WY48
    Related
    ENSP00000221561.7, ENST00000221561.12
    Conserved Domains (1) summary
    pfam03920
    Location:77199
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  3. NM_198970.1NP_945321.1  amino-terminal enhancer of split isoform c

    See identical proteins and their annotated locations for NP_945321.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (c) is shorter, has a distinct N-terminus, and lacks 1 aa in the C-terminus compared to isoform a.
    Source sequence(s)
    AF269289, AK094591, BG696926, BM908356, N23852
    UniProtKB/Swiss-Prot
    Q08117
    UniProtKB/TrEMBL
    Q8WY48
    Conserved Domains (1) summary
    pfam03920
    Location:2131
    TLE_N; Groucho/TLE N-terminal Q-rich domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    3052910..3063107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722664.1XP_006722727.1  amino-terminal enhancer of split isoform X1

    Conserved Domains (1) summary
    pfam03920
    Location:72198
    TLE_N; Groucho/TLE N-terminal Q-rich domain
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