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Tle5 TLE family member 5, transcriptional modulator [ Mus musculus (house mouse) ]

Gene ID: 14797, updated on 12-May-2024

Summary

Official Symbol
Tle5provided by MGI
Official Full Name
TLE family member 5, transcriptional modulatorprovided by MGI
Primary source
MGI:MGI:95806
See related
Ensembl:ENSMUSG00000054452 AllianceGenome:MGI:95806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aes; Grg; Esp1; Grg5; Grg-5
Summary
This gene encodes a protein that belongs to the Aes (amino-terminal enhancer of split) subgroup of the Groucho/transducin-like Enhancer of split (TLE) family of proteins that function as transcriptional corepressors. The encoded protein plays a role in neurological development and cell-fate determination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in adrenal adult (RPKM 1208.9), duodenum adult (RPKM 833.2) and 26 other tissues See more
Orthologs
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Genomic context

See Tle5 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81395278..81402205)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81559444..81566371)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:80973115-80973298 Neighboring gene guanine nucleotide binding protein, alpha 15 Neighboring gene STARR-positive B cell enhancer ABC_E11449 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:80989510-80989711 Neighboring gene guanine nucleotide binding protein, alpha 11 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:81014523-81014724 Neighboring gene STARR-positive B cell enhancer ABC_E3902 Neighboring gene predicted gene, 31936 Neighboring gene transducin-like enhancer of split 2 Neighboring gene transducin-like enhancer of split 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
TLE family member 5
Names
amino-terminal enhancer of split
groucho-related protein 5
related to Drosophila groucho

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276288.1NP_001263217.1  TLE family member 5 isoform 2

    See identical proteins and their annotated locations for NP_001263217.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AK158714, BC145299, BQ174071, BY713872
    UniProtKB/TrEMBL
    B7ZNK7
    Conserved Domains (1) summary
    pfam03920
    Location:11131
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  2. NM_010347.4NP_034477.1  TLE family member 5 isoform 1

    See identical proteins and their annotated locations for NP_034477.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK158714, BQ174071, BY713872
    Consensus CDS
    CCDS24062.1
    UniProtKB/Swiss-Prot
    P63002, Q06195
    UniProtKB/TrEMBL
    Q3TYD9
    Related
    ENSMUSP00000002518.9, ENSMUST00000002518.9
    Conserved Domains (1) summary
    pfam03920
    Location:11132
    TLE_N; Groucho/TLE N-terminal Q-rich domain

RNA

  1. NR_074087.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK158714, BE685863, BQ174071, BY713872

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81395278..81402205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)