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Kif1a kinesin family member 1A [ Mus musculus (house mouse) ]

Gene ID: 16560, updated on 18-Apr-2024

Summary

Official Symbol
Kif1aprovided by MGI
Official Full Name
kinesin family member 1Aprovided by MGI
Primary source
MGI:MGI:108391
See related
Ensembl:ENSMUSG00000014602 AllianceGenome:MGI:108391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ATSV; Kns1; Gm1626; C630002N23Rik
Summary
Enables microtubule binding activity. Predicted to be involved in several processes, including interkinetic nuclear migration; regulation of dendritic spine morphogenesis; and transport along microtubule. Located in neuron projection and neuronal cell body. Is expressed in nervous system; sensory organ; testis; and urinary system. Used to study hereditary spastic paraplegia 30. Human ortholog(s) of this gene implicated in NESCAV syndrome; hereditary sensory neuropathy; hereditary sensory neuropathy type 2C; hereditary spastic paraplegia; and hereditary spastic paraplegia 30. Orthologous to human KIF1A (kinesin family member 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 79.2), frontal lobe adult (RPKM 72.1) and 6 other tissues See more
Orthologs
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Genomic context

Location:
1 D; 1 46.74 cM
Exon count:
51
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (92943180..93029760, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93015455..93102039, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57553 Neighboring gene aquaporin 12 Neighboring gene STARR-seq mESC enhancer starr_01723 Neighboring gene predicted gene, 36472 Neighboring gene alanine-glyoxylate aminotransferase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 
  • Spontaneous (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal dense core vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kinesin-like protein KIF1A
Names
N-3 kinesin
axonal transporter of synaptic vesicles
kinesin heavy chain member 1A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110315.3NP_001103785.1  kinesin-like protein KIF1A isoform b

    Status: VALIDATED

    Source sequence(s)
    AC110247, AC119846
    Consensus CDS
    CCDS48326.1
    UniProtKB/TrEMBL
    E9QAN4, Q6P5H4
    Related
    ENSMUSP00000130717.2, ENSMUST00000171556.8
    Conserved Domains (7) summary
    cd00060
    Location:492596
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:15701672
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam04502
    Location:598676
    DUF572; Family of unknown function (DUF572)
    pfam12423
    Location:805851
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:11481295
    DUF3694; Kinesin protein
    pfam16183
    Location:358515
    Kinesin_assoc; Kinesin-associated
  2. NM_001294149.2NP_001281078.1  kinesin-like protein KIF1A isoform c

    Status: VALIDATED

    Source sequence(s)
    AC110247, AC119846
    Consensus CDS
    CCDS78651.1
    UniProtKB/TrEMBL
    E9Q9G6, Q3UH16
    Related
    ENSMUSP00000108582.3, ENSMUST00000112958.9
    Conserved Domains (7) summary
    cd00060
    Location:492596
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:15791681
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam04502
    Location:598676
    DUF572; Family of unknown function (DUF572)
    pfam12423
    Location:805851
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:11481304
    DUF3694; Kinesin protein
    pfam16183
    Location:358515
    Kinesin_assoc; Kinesin-associated
  3. NM_001294150.2NP_001281079.1  kinesin-like protein KIF1A isoform d

    See identical proteins and their annotated locations for NP_001281079.1

    Status: VALIDATED

    Source sequence(s)
    AC110247, AC119846
    Consensus CDS
    CCDS78652.1
    UniProtKB/TrEMBL
    Q6P5H4, Q6TA13
    Related
    ENSMUSP00000084029.6, ENSMUST00000086819.12
    Conserved Domains (7) summary
    cd00060
    Location:501605
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:15791681
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam04502
    Location:607685
    DUF572; Family of unknown function (DUF572)
    pfam12423
    Location:814860
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:11571304
    DUF3694; Kinesin protein
    pfam16183
    Location:358524
    Kinesin_assoc; Kinesin-associated
  4. NM_001368847.2NP_001355776.1  kinesin-like protein KIF1A isoform e

    Status: VALIDATED

    Source sequence(s)
    AC110247, AC119846
    UniProtKB/Swiss-Prot
    P33173, Q61770
    Conserved Domains (7) summary
    cd00060
    Location:501605
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:15871689
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam04502
    Location:607685
    DUF572; Family of unknown function (DUF572)
    pfam12423
    Location:814860
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:11571312
    DUF3694; Kinesin protein
    pfam16183
    Location:358524
    Kinesin_assoc; Kinesin-associated
  5. NM_001408925.1NP_001395854.1  kinesin-like protein KIF1A isoform f

    Status: VALIDATED

    Source sequence(s)
    AC110247, AC119846
    UniProtKB/TrEMBL
    A0A087WQE8
    Related
    ENSMUSP00000140163.2, ENSMUST00000190723.7
  6. NM_008440.5NP_032466.2  kinesin-like protein KIF1A isoform a

    See identical proteins and their annotated locations for NP_032466.2

    Status: VALIDATED

    Source sequence(s)
    AC110247, AC119846
    Consensus CDS
    CCDS48327.1
    UniProtKB/Swiss-Prot
    P33173, Q61770
    UniProtKB/TrEMBL
    G3UW47
    Related
    ENSMUSP00000128432.2, ENSMUST00000171796.8
    Conserved Domains (7) summary
    cd00060
    Location:492596
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:15781680
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam04502
    Location:598676
    DUF572; Family of unknown function (DUF572)
    pfam12423
    Location:805851
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:11481303
    DUF3694; Kinesin protein
    pfam16183
    Location:358515
    Kinesin_assoc; Kinesin-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    92943180..93029760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529155.5XP_006529218.1  kinesin-like protein KIF1A isoform X1

    UniProtKB/TrEMBL
    Q3UH16
    Conserved Domains (7) summary
    cd00060
    Location:501605
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:16811783
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam04502
    Location:607685
    DUF572; Family of unknown function (DUF572)
    pfam12423
    Location:814861
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:12501406
    DUF3694; Kinesin protein
    pfam16183
    Location:358524
    Kinesin_assoc; Kinesin-associated
  2. XM_036162306.1XP_036018199.1  kinesin-like protein KIF1A isoform X6

    UniProtKB/TrEMBL
    Q3UH16
    Conserved Domains (6) summary
    cd00060
    Location:492596
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:16641766
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam12423
    Location:805852
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:12331389
    DUF3694; Kinesin protein
    pfam16183
    Location:358515
    Kinesin_assoc; Kinesin-associated
  3. XM_036162307.1XP_036018200.1  kinesin-like protein KIF1A isoform X7

    UniProtKB/TrEMBL
    Q6P5H4
    Conserved Domains (6) summary
    cd00060
    Location:492596
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:16631765
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam12423
    Location:805852
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:12411388
    DUF3694; Kinesin protein
    pfam16183
    Location:358515
    Kinesin_assoc; Kinesin-associated
  4. XM_006529159.5XP_006529222.1  kinesin-like protein KIF1A isoform X5

    UniProtKB/TrEMBL
    Q3UH16
    Conserved Domains (7) summary
    cd00060
    Location:492596
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:16721774
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam04502
    Location:598676
    DUF572; Family of unknown function (DUF572)
    pfam12423
    Location:805852
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:12411397
    DUF3694; Kinesin protein
    pfam16183
    Location:358515
    Kinesin_assoc; Kinesin-associated
  5. XM_006529160.5XP_006529223.1  kinesin-like protein KIF1A isoform X8

    UniProtKB/TrEMBL
    Q3UH16
    Conserved Domains (7) summary
    cd00060
    Location:501605
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:15881690
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam04502
    Location:607685
    DUF572; Family of unknown function (DUF572)
    pfam12423
    Location:814860
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:11571313
    DUF3694; Kinesin protein
    pfam16183
    Location:358524
    Kinesin_assoc; Kinesin-associated
  6. XM_006529157.5XP_006529220.1  kinesin-like protein KIF1A isoform X3

    UniProtKB/TrEMBL
    Q3UH16
    Conserved Domains (7) summary
    cd00060
    Location:501605
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:16731775
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam04502
    Location:607685
    DUF572; Family of unknown function (DUF572)
    pfam12423
    Location:814861
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:12421398
    DUF3694; Kinesin protein
    pfam16183
    Location:358524
    Kinesin_assoc; Kinesin-associated
  7. XM_006529156.5XP_006529219.1  kinesin-like protein KIF1A isoform X2

    UniProtKB/Swiss-Prot
    P33173, Q61770
    Conserved Domains (7) summary
    cd00060
    Location:501605
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:16801782
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam04502
    Location:607685
    DUF572; Family of unknown function (DUF572)
    pfam12423
    Location:814861
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:12501405
    DUF3694; Kinesin protein
    pfam16183
    Location:358524
    Kinesin_assoc; Kinesin-associated