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Jak3 Janus kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 16453, updated on 8-Dec-2022

Summary

Official Symbol
Jak3provided by MGI
Official Full Name
Janus kinase 3provided by MGI
Primary source
MGI:MGI:99928
See related
Ensembl:ENSMUSG00000031805 AllianceGenome:MGI:99928
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
fae; wil
Summary
Enables protein tyrosine kinase activity. Involved in several processes, including negative regulation of FasL production; negative regulation of cytokine production; and regulation of apoptotic process. Acts upstream of or within several processes, including cell surface receptor signaling pathway; peptidyl-tyrosine phosphorylation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; acute megakaryocytic leukemia; adult T-cell leukemia; and juvenile myelomonocytic leukemia. Orthologous to human JAK3 (Janus kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 193.9), spleen adult (RPKM 34.5) and 7 other tissues See more
Orthologs
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Genomic context

See Jak3 in Genome Data Viewer
Location:
8 B3.3; 8 34.43 cM
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72129027..72143221)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71676383..71690577)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene collagen beta(1-O)galactosyltransferase 1 Neighboring gene unc-13 homolog A Neighboring gene predicted gene, 39195 Neighboring gene microRNA 6769b Neighboring gene insulin-like 3 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 Neighboring gene predicted gene 45756 Neighboring gene CCR4-NOT transcription complex, subunit 8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cytokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular response to cytokine stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within enzyme-linked receptor protein signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-4-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within lymph node development TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of FasL production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T-helper 1 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of dendritic cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of thymocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to interleukin-15 TAS
Traceable Author Statement
more info
PubMed 
involved_in response to interleukin-2 TAS
Traceable Author Statement
more info
PubMed 
involved_in response to interleukin-4 ISO
Inferred from Sequence Orthology
more info
 
involved_in response to interleukin-4 TAS
Traceable Author Statement
more info
PubMed 
involved_in response to interleukin-9 TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tyrosine-protein kinase JAK3
NP_001177759.1
NP_034719.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190830.1NP_001177759.1  tyrosine-protein kinase JAK3

    See identical proteins and their annotated locations for NP_001177759.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC162033, AK164520
    Consensus CDS
    CCDS22403.1
    UniProtKB/Swiss-Prot
    Q62137
    UniProtKB/TrEMBL
    A0A0R4J0R7
    Related
    ENSMUSP00000105640.4, ENSMUST00000110013.10
    Conserved Domains (5) summary
    smart00295
    Location:41246
    B41; Band 4.1 homologues
    cd13334
    Location:250359
    FERM_C_JAK3; FERM domain C-lobe of Janus kinase (JAK) 3
    pfam07714
    Location:8181091
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:359455
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:8131095
    PKc_like; Protein Kinases, catalytic domain
  2. NM_010589.6NP_034719.2  tyrosine-protein kinase JAK3

    See identical proteins and their annotated locations for NP_034719.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and shares its terminal exon with the insulin-like 3 gene(GeneID:16336). Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC162033, AK038268, AW456897
    Consensus CDS
    CCDS22403.1
    UniProtKB/Swiss-Prot
    Q62137
    UniProtKB/TrEMBL
    A0A0R4J0R7
    Related
    ENSMUSP00000060073.8, ENSMUST00000051995.14
    Conserved Domains (5) summary
    smart00295
    Location:41246
    B41; Band 4.1 homologues
    cd13334
    Location:250359
    FERM_C_JAK3; FERM domain C-lobe of Janus kinase (JAK) 3
    pfam07714
    Location:8181091
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:359455
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:8131095
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    72129027..72143221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)