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Bull Exp Biol Med. 2018 Jan;164(3):316-319. doi: 10.1007/s10517-018-3980-6. Epub 2018 Jan 8.

Particular Role of JAK/STAT3 Signaling in Functional Control of Mesenchymal Progenitor Cells.

Author information

1
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. zgn@pharmso.ru.
2
Laboratory of Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University, Tomsk, Russia. zgn@pharmso.ru.
3
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
4
Laboratory of Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University, Tomsk, Russia.

Abstract

The role of JAK/STAT3-mediated signaling pathway in the realization of the growth potential of mesenchymal precursor cells was examined in vitro. The stimulating role of JAKs and STAT3 towards proliferating activity of progenitor cells and their different role in the regulation of differentiation of the progenitor elements were demonstrated. Inhibitors of JAKs and STAT3 reduced the yield of fibroblast CFU and their mitotic activity. Blockade of JAKs accelerated and selective inactivation of STAT3 decelerated differentiation of progenitor cells.

KEYWORDS:

JAK; STAT; progenitor cells; regenerative medicine; signal transduction

PMID:
29308566
DOI:
10.1007/s10517-018-3980-6
[Indexed for MEDLINE]

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