U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Inhbb inhibin beta-B [ Mus musculus (house mouse) ]

Gene ID: 16324, updated on 12-May-2024

Summary

Official Symbol
Inhbbprovided by MGI
Official Full Name
inhibin beta-Bprovided by MGI
Primary source
MGI:MGI:96571
See related
Ensembl:ENSMUSG00000037035 AllianceGenome:MGI:96571
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Homozygous knockout mice for this gene exhibit eyelid defects. [provided by RefSeq, Aug 2016]
Expression
Biased expression in ovary adult (RPKM 148.1), mammary gland adult (RPKM 18.2) and 3 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Inhbb in Genome Data Viewer
Location:
1 E2.3; 1 52.29 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (119343193..119349978, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (119415463..119422248, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3508 Neighboring gene STARR-seq mESC enhancer starr_02022 Neighboring gene STARR-seq mESC enhancer starr_02025 Neighboring gene predicted gene, 33388 Neighboring gene STARR-seq mESC enhancer starr_02027 Neighboring gene STARR-seq mESC enhancer starr_02028 Neighboring gene STARR-seq mESC enhancer starr_02029 Neighboring gene predicted gene, 41935 Neighboring gene predicted gene, 33490 Neighboring gene predicted gene, 33575

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to cholesterol ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to leptin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in eye development TAS
Traceable Author Statement
more info
PubMed 
involved_in fat cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of follicle-stimulating hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hepatocyte growth factor production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within oocyte development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of follicle-stimulating hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ovulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
inhibin beta B chain
Names
activin beta-B chain

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008381.4NP_032407.1  inhibin beta B chain preproprotein

    See identical proteins and their annotated locations for NP_032407.1

    Status: REVIEWED

    Source sequence(s)
    AK132352, BP771405, CB245693
    Consensus CDS
    CCDS15224.1
    UniProtKB/Swiss-Prot
    Q04999, Q3V1N0, Q61277, Q80VC4
    Related
    ENSMUSP00000044918.6, ENSMUST00000038765.6
    Conserved Domains (2) summary
    smart00204
    Location:307410
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:73282
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    119343193..119349978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)