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INHBB inhibin subunit beta B [ Homo sapiens (human) ]

Gene ID: 3625, updated on 1-Jun-2020

Summary

Official Symbol
INHBBprovided by HGNC
Official Full Name
inhibin subunit beta Bprovided by HGNC
Primary source
HGNC:HGNC:6067
See related
Ensembl:ENSG00000163083 MIM:147390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Polymorphisms near this gene are associated with pre-eclampsia in female human patients. [provided by RefSeq, Aug 2016]
Expression
Biased expression in fat (RPKM 16.6), testis (RPKM 13.1) and 13 other tissues See more
Orthologs

Genomic context

See INHBB in Genome Data Viewer
Location:
2q14.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (120346136..120351803)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (121103719..121109383)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373584 Neighboring gene putative cuticle collagen 91 Neighboring gene CRISPRi-validated cis-regulatory element chr2.4367 Neighboring gene long intergenic non-protein coding RNA 1101 Neighboring gene uncharacterized LOC105373585

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study on obesity and obesity-related traits.
NHGRI GWA Catalog
Genetic variants associated with breast size also influence breast cancer risk.
NHGRI GWA Catalog
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
NHGRI GWA Catalog
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC157939

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity TAS
Traceable Author Statement
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
hormone activity TAS
Traceable Author Statement
more info
PubMed 
host cell surface receptor binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adhesion of symbiont to host cell IEA
Inferred from Electronic Annotation
more info
 
cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to leptin stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response TAS
Traceable Author Statement
more info
PubMed 
fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of follicle-stimulating hormone secretion IPI
Inferred from Physical Interaction
more info
PubMed 
negative regulation of hepatocyte growth factor biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
oocyte development IEA
Inferred from Electronic Annotation
more info
 
ovarian follicle development NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of follicle-stimulating hormone secretion IPI
Inferred from Physical Interaction
more info
PubMed 
positive regulation of ovulation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cell periphery IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
inhibin beta B chain
Names
Inhibin, beta-2
activin AB beta polypeptide
activin beta-B chain
inhibin beta B subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002193.4NP_002184.2  inhibin beta B chain preproprotein

    See identical proteins and their annotated locations for NP_002184.2

    Status: REVIEWED

    Source sequence(s)
    AC012363, AI659282, AI671596, BC030029, BI545428, CK430845, M13437, M31682
    Consensus CDS
    CCDS2132.1
    UniProtKB/Swiss-Prot
    P09529
    Related
    ENSP00000295228.3, ENST00000295228.4
    Conserved Domains (2) summary
    smart00204
    Location:303406
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:57278
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    120346136..120351803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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