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ZNF433 zinc finger protein 433 [ Homo sapiens (human) ]

Gene ID: 163059, updated on 13-May-2022

Summary

Official Symbol
ZNF433provided by HGNC
Official Full Name
zinc finger protein 433provided by HGNC
Primary source
HGNC:HGNC:20811
See related
Ensembl:ENSG00000197647 AllianceGenome:HGNC:20811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 9.0), thyroid (RPKM 2.5) and 21 other tissues See more
Orthologs
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Genomic context

See ZNF433 in Genome Data Viewer
Location:
19p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12014715..12035679, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12142922..12163886, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12125530..12146494, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 69 Neighboring gene Sharpr-MPRA regulatory region 6121 Neighboring gene zinc finger protein 763 Neighboring gene ZNF433 and ZNF878 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 464 Neighboring gene RNA, 5S ribosomal pseudogene 465 Neighboring gene zinc finger protein 878 Neighboring gene RNA, 5S ribosomal pseudogene 466 Neighboring gene zinc finger protein 844

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40981

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080411.3NP_001073880.1  zinc finger protein 433 isoform 1

    See identical proteins and their annotated locations for NP_001073880.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest isoform (1).
    Source sequence(s)
    AC008770, AK098300, DB515835
    Consensus CDS
    CCDS45983.1
    UniProtKB/Swiss-Prot
    Q8N7K0
    Related
    ENSP00000339767.6, ENST00000344980.11
    Conserved Domains (5) summary
    smart00349
    Location:749
    KRAB; krueppel associated box
    COG5048
    Location:197603
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:228248
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:746
    KRAB; KRAB box
    pfam13465
    Location:240265
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001308346.2NP_001295275.1  zinc finger protein 433 isoform 2

    See identical proteins and their annotated locations for NP_001295275.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate exon in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC008770, BC047412, DB454511, DB515835
    UniProtKB/Swiss-Prot
    Q8N7K0
    Related
    ENSP00000447205.2, ENST00000550745.3
    Conserved Domains (5) summary
    smart00349
    Location:648
    KRAB; krueppel associated box
    COG5048
    Location:196602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227247
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:239264
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001308348.2NP_001295277.1  zinc finger protein 433 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC008770, BC047412, CN345816, DA452530, DB515835
    UniProtKB/Swiss-Prot
    Q8N7K0
    Related
    ENSP00000448099.2, ENST00000550507.7
    Conserved Domains (5) summary
    smart00349
    Location:446
    KRAB; krueppel associated box
    COG5048
    Location:194600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:225245
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:237262
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001308351.2NP_001295280.1  zinc finger protein 433 isoform 4

    See identical proteins and their annotated locations for NP_001295280.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses two alternate exons and an alternate splice site in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 4, which has a shorter N-terminus than isoform 1. Variants 4, 5, and 6 encode the same isoform.
    Source sequence(s)
    AC008770, BC047412, BI831553, DB515835
    Consensus CDS
    CCDS77240.1
    UniProtKB/Swiss-Prot
    Q8N7K0
    UniProtKB/TrEMBL
    A0A024R7H6
    Conserved Domains (2) summary
    COG5048
    Location:162568
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:193213
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001308355.2NP_001295284.1  zinc finger protein 433 isoform 4

    See identical proteins and their annotated locations for NP_001295284.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate exon and alternate splice site in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 4, which has a shorter N-terminus compared to isoform 1. Variants 4, 5, and 6 encode the same isoform.
    Source sequence(s)
    AC008770, BC047412, DA452530, DB450226, DB515835
    Consensus CDS
    CCDS77240.1
    UniProtKB/Swiss-Prot
    Q8N7K0
    UniProtKB/TrEMBL
    A0A024R7H6
    Related
    ENSP00000448806.2, ENST00000547560.6
    Conserved Domains (2) summary
    COG5048
    Location:162568
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:193213
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001308357.2NP_001295286.1  zinc finger protein 433 isoform 4

    See identical proteins and their annotated locations for NP_001295286.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate exon and alternate splice site in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 4, which has a shorter N-terminus compared to isoform 1. Variants 4, 5, and 6 encode the same isoform.
    Source sequence(s)
    AC008770, BC047412, DA452530, DB515835
    Consensus CDS
    CCDS77240.1
    UniProtKB/Swiss-Prot
    Q8N7K0
    UniProtKB/TrEMBL
    A0A024R7H6
    Related
    ENSP00000393416.2, ENST00000419886.7
    Conserved Domains (2) summary
    COG5048
    Location:162568
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:193213
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    12014715..12035679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527725.3XP_011526027.1  zinc finger protein 433 isoform X2

    See identical proteins and their annotated locations for XP_011526027.1

    Related
    ENSP00000447951.2, ENST00000478765.6
    Conserved Domains (5) summary
    smart00349
    Location:1860
    KRAB; krueppel associated box
    COG5048
    Location:208614
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:239259
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1857
    KRAB; KRAB box
    pfam13465
    Location:251276
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011527729.3XP_011526031.1  zinc finger protein 433 isoform X3

    See identical proteins and their annotated locations for XP_011526031.1

    Related
    ENSP00000414857.3, ENST00000455504.7
    Conserved Domains (5) summary
    smart00349
    Location:648
    KRAB; krueppel associated box
    COG5048
    Location:196602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227247
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:239264
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011527728.3XP_011526030.1  zinc finger protein 433 isoform X3

    See identical proteins and their annotated locations for XP_011526030.1

    Conserved Domains (5) summary
    smart00349
    Location:648
    KRAB; krueppel associated box
    COG5048
    Location:196602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227247
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:239264
    zf-H2C2_2; Zinc-finger double domain
  4. XM_047438319.1XP_047294275.1  zinc finger protein 433 isoform X1

  5. XM_006722661.4XP_006722724.1  zinc finger protein 433 isoform X4

    See identical proteins and their annotated locations for XP_006722724.1

    UniProtKB/Swiss-Prot
    Q8N7K0
    UniProtKB/TrEMBL
    A0A024R7H6
    Conserved Domains (2) summary
    COG5048
    Location:162568
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:193213
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    12142922..12163886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152602.1: Suppressed sequence

    Description
    NM_152602.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from laboratory mouse: 3000002G13Rik (GeneID:70227).