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AP2B1 adaptor related protein complex 2 subunit beta 1 [ Homo sapiens (human) ]

Gene ID: 163, updated on 18-Nov-2018

Summary

Official Symbol
AP2B1provided by HGNC
Official Full Name
adaptor related protein complex 2 subunit beta 1provided by HGNC
Primary source
HGNC:HGNC:563
See related
Ensembl:ENSG00000006125 MIM:601025; Vega:OTTHUMG00000179924
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADTB2; AP105B; CLAPB1; AP2-BETA
Summary
The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 64.4), testis (RPKM 50.1) and 25 other tissues See more
Orthologs

Genomic context

See AP2B1 in Genome Data Viewer
Location:
17q12
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (35587263..35726417)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (33913918..34053436)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2001 Neighboring gene small nucleolar RNA, C/D box 7 Neighboring gene peroxisomal biogenesis factor 12 Neighboring gene transmembrane protein 160 pseudogene Neighboring gene ribosomal protein L17 pseudogene 42 Neighboring gene RAS like family 10 member B Neighboring gene growth arrest specific 2 like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 Env gp41 requires the conserved membrane-proximal AP2B1 binding site in the gp41 cytoplasmic tail to evade antibody-dependent cell-mediated cytotoxicity (ADCC) via membrane-proximal endocytosis PubMed
env Two independent motifs, a membrane proximal conserved GYxxO motif (residues 711-715) and a C-terminal dileucine motif (residues 855-856), of the HIV-1 gp41 protein mediate endocytosis through interaction with the clathrin adaptor AP-2 PubMed
env The cytoplasmic domain (residues 707-856) of HIV-1 gp41 interacts with whole clathrin-associated AP-1 and AP-2 adaptor complexes PubMed
Nef nef Clathrin and the clathrin-associated, plasma membrane-localized AP2 complexes are required for the HIV-1 Nef-mediated downregulation of CD4 PubMed
nef A dileucine-motif-containing segment of Nef binds directly to the beta subunit of the clathrin adaptor complexes AP-2, which are responsible for recruiting sorted proteins into clathrin coated pits PubMed
nef HIV-1 Nef co-localizes with the beta subunit of the adaptor protein complexes (AP-2) in human T cells; Nef residues 174-179 are required for the co-localization of Nef with the beta subunit PubMed
nef In cells expressing an HIV-1 Nef-green fluorescent protein (GFP) fusion, CD28 co-localizes with the AP-2 clathrin adaptor and Nef-GFP PubMed
Pr55(Gag) gag HIV-1 Gag binds to AP-2, and this binding is dependent on tyrosine residue 132 and valine residue 135 at the matrix-capsid junction in the Gag polyprotein PubMed
Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides upregulate gene expression of adaptor-related protein complex 2, beta 1 subunit (AP2B1) in U-937 macrophages PubMed
tat HIV-1 Tat enters T cells by using clathrin/AP2-mediated endocytosis followed by low-pH-induced and Hsp90-assisted endosomal translocation, which leads to cell responses that are induced from the cytosol PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Beta-catenin independent WNT signaling, organism-specific biosystem (from REACTOME)
    Beta-catenin independent WNT signaling, organism-specific biosystemHumans and mice have 19 identified WNT proteins that were originally classified as either 'canonical' or 'non-canonical' depending upon whether they were able to transform the mouse mammary epithelia...
  • Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
    Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystemRecruitment of plasma membrane-localized cargo into clathrin-coated endocytic vesicles is mediated by interaction with a variety of clathrin-interacting proteins collectively called CLASPs (clathrin-...
  • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
    Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
  • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
    EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
  • EPH-ephrin mediated repulsion of cells, organism-specific biosystem (from REACTOME)
    EPH-ephrin mediated repulsion of cells, organism-specific biosystemDespite high-affinity multimeric interaction between EPHs and ephrins (EFNs), the cellular response to EPH-EFN engagement is usually repulsion between the two cells and signal termination. These repu...
  • Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem (from KEGG)
    Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
  • Endocrine and other factor-regulated calcium reabsorption, conserved biosystem (from KEGG)
    Endocrine and other factor-regulated calcium reabsorption, conserved biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystem (from REACTOME)
    Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystemExcitatory synaptic transmission in the brain is carried out by glutamate receptors through the activation of both ionotropic and metabotropic receptors. Ionotropic glutamate receptors are of three ...
  • HIV Infection, organism-specific biosystem (from REACTOME)
    HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
  • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
    Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Infectious disease, organism-specific biosystem (from REACTOME)
    Infectious disease, organism-specific biosystem
    Infectious disease
  • L1CAM interactions, organism-specific biosystem (from REACTOME)
    L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
  • LDL-mediated lipid transport, organism-specific biosystem (from REACTOME)
    LDL-mediated lipid transport, organism-specific biosystemLDL (low density lipoproteins) are complexes of a single molecule of apoprotein B-100 (apoB-100) non-covalently associated with triacylglycerol, free cholesterol, cholesterol esters, and phospholipid...
  • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
    Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
  • Lipoprotein metabolism, organism-specific biosystem (from REACTOME)
    Lipoprotein metabolism, organism-specific biosystemBecause of their hydrophobicity, lipids are found in the extracellular spaces of the human body primarily in the form of lipoprotein complexes. Chylomicrons form in the small intestine and transport ...
  • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
    MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
    NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
  • Nef Mediated CD4 Down-regulation, organism-specific biosystem (from REACTOME)
    Nef Mediated CD4 Down-regulation, organism-specific biosystemThe presence of Nef accelerates endocytosis and lysosomal degradation of the transmembrane glycoprotein CD4. CD4 has its own internalization motif, though this motif is normally concealed by CD4 inte...
  • Nef Mediated CD8 Down-regulation, organism-specific biosystem (from REACTOME)
    Nef Mediated CD8 Down-regulation, organism-specific biosystemHuman immunodeficiency virus (HIV) Nef is a membrane-associated protein decreasing surface expression of CD4, CD28, and major histocompatibility complex class I on infected cells. Nef also strongly d...
  • Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, organism-specific biosystem (from REACTOME)
    Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, organism-specific biosystemThe maximal virulence of HIV-1 requires Nef, a virally encoded peripheral membrane protein. Nef binds to the adaptor protein (AP) complexes of coated vesicles, inducing an expansion of the endosomal ...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemThe neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein cou...
  • PCP/CE pathway, organism-specific biosystem (from REACTOME)
    PCP/CE pathway, organism-specific biosystemThe planar cell polarity (PCP) pathway controls the establishment of polarity within the plane of a sheet of cells. PCP was initially characterized in Drosophila, where it controls the arrangement o...
  • Recycling pathway of L1, organism-specific biosystem (from REACTOME)
    Recycling pathway of L1, organism-specific biosystemL1 functions in many aspects of neuronal development including axon outgrowth and neuronal migration. These functions require coordination between L1 and the actin cytoskeleton. F-actin continuously ...
  • Retrograde neurotrophin signalling, organism-specific biosystem (from REACTOME)
    Retrograde neurotrophin signalling, organism-specific biosystemNeurotrophin-TRK complexes can be internalized and enter signalling vesicles, which travel retrogradely over long distances from distal nerve terminals to neuronal cell bodies. Such retrograde signal...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Wnt, organism-specific biosystem (from REACTOME)
    Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • Synaptic Vesicle Pathway, organism-specific biosystem (from WikiPathways)
    Synaptic Vesicle Pathway, organism-specific biosystemPathway depicting synaptic transmission of neurotransmitters from the presynaptic nerve terminal to the synaptic cleft upon depolarization. Synaptotagmin mediated transport along the nerve cell cytos...
  • Synaptic vesicle cycle, organism-specific biosystem (from KEGG)
    Synaptic vesicle cycle, organism-specific biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
  • Synaptic vesicle cycle, conserved biosystem (from KEGG)
    Synaptic vesicle cycle, conserved biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
  • The role of Nef in HIV-1 replication and disease pathogenesis, organism-specific biosystem (from REACTOME)
    The role of Nef in HIV-1 replication and disease pathogenesis, organism-specific biosystemThe HIV-1 Nef protein is a 27-kDa myristoylated protein that is abundantly produced during the early phase of viral replication cycle. It is highly conserved in all primate lentiviruses, suggesting t...
  • Trafficking of AMPA receptors, organism-specific biosystem (from REACTOME)
    Trafficking of AMPA receptors, organism-specific biosystemRepetitive presynaptic activity causes long lasting changes in the postsynaptic transmission by changing the type and the number of AMPA receptors. These changes are brought about by trafficking mec...
  • Trafficking of GluR2-containing AMPA receptors, organism-specific biosystem (from REACTOME)
    Trafficking of GluR2-containing AMPA receptors, organism-specific biosystemTrafficking of GluR2-containing receptors is governed by protein protein interactions that are regulated by phosphorylation events. GluR2 binds NSF and AP2 in the proximal C terminal region and binds...
  • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
    Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
  • VLDL interactions, organism-specific biosystem (from REACTOME)
    VLDL interactions, organism-specific biosystemVery-low-density lipoprotein (VLDL) is a lipoprotein made by the liver (Gibbons et al. 2004) and is one of the five major groups of lipoproteins (chylomicrons, VLDL, LDL, IDL and HDL) that enable fat...
  • VLDLR internalisation and degradation, organism-specific biosystem (from REACTOME)
    VLDLR internalisation and degradation, organism-specific biosystemThe steps involved in proprotein convertase PCSK9-induced degradation of VLDLR are described here (Poirier et al. 2008).
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
  • WNT5A-dependent internalization of FZD2, FZD5 and ROR2, organism-specific biosystem (from REACTOME)
    WNT5A-dependent internalization of FZD2, FZD5 and ROR2, organism-specific biosystemInternalization of FZD2, FZD5 and ROR2 after WNT5A binding is thought to occur in a clathrin-dependent manner and is required for the activation of RAC signaling (Kurayoshi et al, 2007; Sato et al, 2...
  • WNT5A-dependent internalization of FZD4, organism-specific biosystem (from REACTOME)
    WNT5A-dependent internalization of FZD4, organism-specific biosystemWNT5A induces internalization of FZD4 in a manner that depends upon PKC-mediated phosphorylation of DVL2. Uptake of FZD4 appears to occur in a clathrin, AP-2 and ARBB2-dependent mannner (Chen et al,...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781K0743

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to clathrin adaptor activity TAS
Traceable Author Statement
more info
PubMed 
clathrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
clathrin binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
signal sequence binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway, planar cell polarity pathway TAS
Traceable Author Statement
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
aorta development IEA
Inferred from Electronic Annotation
more info
 
clathrin coat assembly IEA
Inferred from Electronic Annotation
more info
 
clathrin-dependent endocytosis TAS
Traceable Author Statement
more info
PubMed 
coronary vasculature development IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
low-density lipoprotein particle clearance TAS
Traceable Author Statement
more info
 
low-density lipoprotein particle receptor catabolic process TAS
Traceable Author Statement
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein localization to membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic neurotransmitter receptor internalization IEA
Inferred from Electronic Annotation
more info
 
regulation of defense response to virus by virus TAS
Traceable Author Statement
more info
 
ventricular septum development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
AP-2 adaptor complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
AP-2 adaptor complex TAS
Traceable Author Statement
more info
PubMed 
clathrin-coated endocytic vesicle NAS
Non-traceable Author Statement
more info
PubMed 
clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
endolysosome membrane TAS
Traceable Author Statement
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
AP-2 complex subunit beta
Names
adapter-related protein complex 2 beta subunit
adapter-related protein complex 2 subunit beta
adaptin, beta 2 (beta)
adaptor protein complex AP-2 subunit beta
adaptor related protein complex 2 beta 1 subunit
adaptor-related protein complex 2 subunit beta
beta-2-adaptin
beta-adaptin
clathrin assembly protein complex 2 beta large chain
clathrin-associated/assembly/adaptor protein, large, beta 1
plasma membrane adaptor HA2/AP2 adaptin beta subunit
testicular tissue protein Li 22

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030006.1NP_001025177.1  AP-2 complex subunit beta isoform a

    See identical proteins and their annotated locations for NP_001025177.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AI691147, BC006201, BC012150, BQ421703, BX643620, M34175
    Consensus CDS
    CCDS32621.1
    UniProtKB/Swiss-Prot
    P63010
    UniProtKB/TrEMBL
    A0A140VJE8, Q96EL6
    Related
    ENSP00000483185.1, OTTHUMP00000276620, ENST00000610402.4, OTTHUMT00000477284
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  2. NM_001282.2NP_001273.1  AP-2 complex subunit beta isoform b

    See identical proteins and their annotated locations for NP_001273.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AI691147, BQ421703, BX643620, M34175
    Consensus CDS
    CCDS32622.1
    UniProtKB/Swiss-Prot
    P63010
    Related
    ENSP00000482315.1, OTTHUMP00000276615, ENST00000621914.4, OTTHUMT00000477281
    Conserved Domains (4) summary
    smart00809
    Location:717817
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:826936
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    35587263..35726417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524452.1XP_011522754.1  AP-2 complex subunit beta isoform X5

    See identical proteins and their annotated locations for XP_011522754.1

    Conserved Domains (5) summary
    smart00809
    Location:674768
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:815925
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    pfam01602
    Location:1477
    Adaptin_N; Adaptin N terminal region
    pfam12717
    Location:42211
    Cnd1; non-SMC mitotic condensation complex subunit 1
    sd00044
    Location:3057
    HEAT; HEAT repeat [structural motif]
  2. XM_017024285.1XP_016879774.1  AP-2 complex subunit beta isoform X6

  3. XM_011524448.2XP_011522750.1  AP-2 complex subunit beta isoform X1

    See identical proteins and their annotated locations for XP_011522750.1

    Conserved Domains (4) summary
    smart00809
    Location:731825
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:872982
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  4. XM_011524451.2XP_011522753.1  AP-2 complex subunit beta isoform X2

    Conserved Domains (4) summary
    smart00809
    Location:717811
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:858968
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  5. XM_005257941.3XP_005257998.1  AP-2 complex subunit beta isoform X8

    Related
    ENSP00000478471.1, OTTHUMP00000276614, ENST00000616784.4
    Conserved Domains (3) summary
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
    pfam12717
    Location:99268
    Cnd1; non-SMC mitotic condensation complex subunit 1
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
  6. XM_011524453.1XP_011522755.1  AP-2 complex subunit beta isoform X5

    See identical proteins and their annotated locations for XP_011522755.1

    Conserved Domains (5) summary
    smart00809
    Location:674768
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:815925
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    pfam01602
    Location:1477
    Adaptin_N; Adaptin N terminal region
    pfam12717
    Location:42211
    Cnd1; non-SMC mitotic condensation complex subunit 1
    sd00044
    Location:3057
    HEAT; HEAT repeat [structural motif]
  7. XM_011524455.2XP_011522757.1  AP-2 complex subunit beta isoform X7

    See identical proteins and their annotated locations for XP_011522757.1

    UniProtKB/Swiss-Prot
    P63010
    Conserved Domains (4) summary
    smart00809
    Location:660760
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:769879
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:3057
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:1477
    Adaptin_N; Adaptin N terminal region
  8. XM_011524449.3XP_011522751.1  AP-2 complex subunit beta isoform X1

    See identical proteins and their annotated locations for XP_011522751.1

    Conserved Domains (4) summary
    smart00809
    Location:731825
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:872982
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  9. XM_005257937.4XP_005257994.1  AP-2 complex subunit beta isoform X3

    See identical proteins and their annotated locations for XP_005257994.1

    UniProtKB/Swiss-Prot
    P63010
    UniProtKB/TrEMBL
    A0A140VJE8
    Related
    ENSP00000484708.1, OTTHUMP00000276617, ENST00000616681.4
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  10. XM_017024284.2XP_016879773.1  AP-2 complex subunit beta isoform X4

    UniProtKB/Swiss-Prot
    P63010
    Conserved Domains (4) summary
    smart00809
    Location:717817
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:826936
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  11. XM_017024287.2XP_016879776.1  AP-2 complex subunit beta isoform X8

    Related
    ENSP00000479691.1, OTTHUMP00000276621, ENST00000614600.4
    Conserved Domains (3) summary
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
    pfam12717
    Location:99268
    Cnd1; non-SMC mitotic condensation complex subunit 1
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
  12. XM_017024286.1XP_016879775.1  AP-2 complex subunit beta isoform X7

    UniProtKB/Swiss-Prot
    P63010
    Conserved Domains (4) summary
    smart00809
    Location:660760
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:769879
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:3057
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:1477
    Adaptin_N; Adaptin N terminal region
  13. XM_011524450.2XP_011522752.1  AP-2 complex subunit beta isoform X1

    See identical proteins and their annotated locations for XP_011522752.1

    Conserved Domains (4) summary
    smart00809
    Location:731825
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:872982
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  14. XM_005257938.3XP_005257995.1  AP-2 complex subunit beta isoform X3

    See identical proteins and their annotated locations for XP_005257995.1

    UniProtKB/Swiss-Prot
    P63010
    UniProtKB/TrEMBL
    A0A140VJE8
    Related
    ENSP00000482835.1, ENST00000618940.4
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  15. XM_011524454.1XP_011522756.1  AP-2 complex subunit beta isoform X5

    See identical proteins and their annotated locations for XP_011522756.1

    Conserved Domains (5) summary
    smart00809
    Location:674768
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:815925
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    pfam01602
    Location:1477
    Adaptin_N; Adaptin N terminal region
    pfam12717
    Location:42211
    Cnd1; non-SMC mitotic condensation complex subunit 1
    sd00044
    Location:3057
    HEAT; HEAT repeat [structural motif]
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