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Il6st interleukin 6 signal transducer [ Mus musculus (house mouse) ]

Gene ID: 16195, updated on 14-Sep-2021

Summary

Official Symbol
Il6stprovided by MGI
Official Full Name
interleukin 6 signal transducerprovided by MGI
Primary source
MGI:MGI:96560
See related
Ensembl:ENSMUSG00000021756
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gp13; CD130; gp130; AA389424; BB405851; D13Ertd699; D13Ertd699e; 5133400A03Rik
Expression
Ubiquitous expression in bladder adult (RPKM 57.5), subcutaneous fat pad adult (RPKM 32.9) and 24 other tissues See more
Orthologs
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Genomic context

See Il6st in Genome Data Viewer
Location:
13 D2.2; 13 63.73 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (112600604..112643394)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (112464070..112506860)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (113254278..113297068)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 55 Neighboring gene predicted gene, 48837 Neighboring gene predicted gene, 33905 Neighboring gene interleukin 31 receptor A Neighboring gene tubulin, alpha 1B pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ciliary neurotrophic factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ciliary neurotrophic factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to interleukin-11 binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to interleukin-11 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to interleukin-6 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to interleukin-6 binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to interleukin-6 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to interleukin-6 receptor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to interleukin-6 receptor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to leukemia inhibitory factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to oncostatin-M receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ciliary neurotrophic factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interleukin-27-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-6-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intestinal epithelial cell development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intestinal epithelial cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in leukemia inhibitory factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in oncostatin-M-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to cytokine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in triglyceride mobilization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
part_of ciliary neurotrophic factor receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
part_of interleukin-6 receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
 
part_of oncostatin-M receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-6 receptor subunit beta
Names
IL-6 receptor subunit beta
IL-6R subunit beta
IL-6R-beta
IL-6RB
membrane glycoprotein 130
oncostatin-M receptor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010560.3NP_034690.3  interleukin-6 receptor subunit beta precursor

    See identical proteins and their annotated locations for NP_034690.3

    Status: VALIDATED

    Source sequence(s)
    BC058679, BU709006, CJ177012, CV556562
    Consensus CDS
    CCDS26773.1
    UniProtKB/Swiss-Prot
    Q00560
    UniProtKB/TrEMBL
    Q6PDI9
    Related
    ENSMUSP00000138836.2, ENSMUST00000183663.8
    Conserved Domains (4) summary
    smart00060
    Location:521597
    FN3; Fibronectin type 3 domain
    cd00063
    Location:220319
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26112
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:125213
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    112600604..112643394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157858.1XP_036013751.1  interleukin-6 receptor subunit beta isoform X1

    Conserved Domains (4) summary
    smart00060
    Location:521597
    FN3; Fibronectin type 3 domain
    cd00063
    Location:220319
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26112
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:125213
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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