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IL6ST interleukin 6 signal transducer [ Homo sapiens (human) ]

Gene ID: 3572, updated on 7-Dec-2018

Summary

Official Symbol
IL6STprovided by HGNC
Official Full Name
interleukin 6 signal transducerprovided by HGNC
Primary source
HGNC:HGNC:6021
See related
Ensembl:ENSG00000134352 MIM:600694
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD130; GP130; CDW130; IL-6RB
Summary
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
Expression
Ubiquitous expression in placenta (RPKM 88.6), fat (RPKM 53.5) and 24 other tissues See more
Orthologs

Genomic context

See IL6ST in Genome Data Viewer
Location:
5q11.2
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (55935095..55994993, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (55230923..55290821, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein H1 pseudogene 3 Neighboring gene interleukin 31 receptor A Neighboring gene uncharacterized LOC441072 Neighboring gene uncharacterized LOC105378976 Neighboring gene ankyrin repeat domain 55

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of interleukin 6 signal transducer (IL6ST; gp130, oncostatin M receptor; CD130) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef downregulates the cell surface expression of interleukin 6 signal transducer (IL6ST, CD130) PubMed
Tat tat HIV-1 Tat upregulates the expression of interleukin 6 signal transducer gene (IL6ST; GP130) in mammary epithelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • IL-6 signaling pathway, organism-specific biosystem (from WikiPathways)
    IL-6 signaling pathway, organism-specific biosystemIL-6 is a pleiotropic cytokine with important role in immune regulation, hematopoiesis, inflammation and oncogenesis. IL-6-type cytokines exert their action via the signal transducer gp130 that assoc...
  • IL-6-type cytokine receptor ligand interactions, organism-specific biosystem (from REACTOME)
    IL-6-type cytokine receptor ligand interactions, organism-specific biosystemThe members involved in (interleukin)-6-type cytokine signalling are the IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncostatin M), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CTF1)...
  • IL27-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL27-mediated signaling events, organism-specific biosystem
    IL27-mediated signaling events
  • IL6-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL6-mediated signaling events, organism-specific biosystem
    IL6-mediated signaling events
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interleukin-11 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Interleukin-11 Signaling Pathway, organism-specific biosystemIL-11 is a multifunctional cytokine that belongs to the gp130 family. It was first isolated from a primate bone marrow derived cell line, PU-34 for its ability to stimulate the proliferation of a pla...
  • Interleukin-6 family signaling, organism-specific biosystem (from REACTOME)
    Interleukin-6 family signaling, organism-specific biosystemThe interleukin (IL)-6 family of cytokines is defined by the shared use of the common signal transducing receptor gp130 beta-subunit. This family includes structurally and functionally related IL-6, ...
  • Interleukin-6 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-6 signaling, organism-specific biosystemInterleukin-6 (IL-6) is a pleiotropic cytokine with roles in processes including immune regulation, hematopoiesis, inflammation, oncogenesis, metabolic control and sleep. It is the founding member o...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
    MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
  • MAPK1 (ERK2) activation, organism-specific biosystem (from REACTOME)
    MAPK1 (ERK2) activation, organism-specific biosystemMitogen-activated protein kinase kinase MAP2K2 (also known as MEK2) is a dual threonine and tyrosine recognition kinase that phosphorylates and activates MAPK1 (ERK2) (Ohren et al. 2004; Roskoski 201...
  • MAPK1/MAPK3 signaling, organism-specific biosystem (from REACTOME)
    MAPK1/MAPK3 signaling, organism-specific biosystemThe extracellular signal regulated kinases (ERKs) 1 and 2, also known as MAPK3 and MAPK1, are phosphorylated by the MAP2Ks 1 and 2 in response to a wide range of extracellular stimuli to promote diff...
  • MAPK3 (ERK1) activation, organism-specific biosystem (from REACTOME)
    MAPK3 (ERK1) activation, organism-specific biosystemMitogen-activated protein kinase kinase MAP2K1 (also known as MEK1) is a dual threonine and tyrosine recognition kinase that phosphorylates and activates MAPK3 (ERK1) (Ohren et al. 2004; Roskoski 201...
  • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
    MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
  • Oncostatin M Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Oncostatin M Signaling Pathway, organism-specific biosystemOncostatin M (OSM) is a member of the multifunctional cytokine interleukin 6 (IL6) - type cytokine family. It is mainly produced in cell types such as activated T lymphocytes, macrophages, monocytes,...
  • Physiological and Pathological Hypertrophy of the Heart, organism-specific biosystem (from WikiPathways)
    Physiological and Pathological Hypertrophy of the Heart, organism-specific biosystemPathways in physiological and pathological hypertrophy of the heart. Largely based on the article from Wang Y; ''Signal transduction in cardiac hypertrophy--dissecting compensatory versus pathologica...
  • RAF-independent MAPK1/3 activation, organism-specific biosystem (from REACTOME)
    RAF-independent MAPK1/3 activation, organism-specific biosystemDepending upon the stimulus and cell type mitogen-activated protein kinases (MAPK) signaling pathway can transmit signals to regulate many different biological processes by virtue of their ability to...
  • Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
    Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Th17 cell differentiation, organism-specific biosystem (from KEGG)
    Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
  • Th17 cell differentiation, conserved biosystem (from KEGG)
    Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564F053

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ciliary neurotrophic factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
ciliary neurotrophic factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ciliary neurotrophic factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
interleukin-11 binding IEA
Inferred from Electronic Annotation
more info
 
interleukin-11 receptor activity IEA
Inferred from Electronic Annotation
more info
 
interleukin-27 receptor activity IC
Inferred by Curator
more info
PubMed 
contributes_to interleukin-6 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to interleukin-6 binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to interleukin-6 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to interleukin-6 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to interleukin-6 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to interleukin-6 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to leukemia inhibitory factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to leukemia inhibitory factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to oncostatin-M receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to oncostatin-M receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ciliary neurotrophic factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
interleukin-11-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
interleukin-27-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-27-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-35-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-6-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-6-mediated signaling pathway TAS
Traceable Author Statement
more info
 
leukemia inhibitory factor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
oncostatin-M-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of acute inflammatory response IC
Inferred by Curator
more info
PubMed 
positive regulation of adaptive immune response IC
Inferred by Curator
more info
PubMed 
positive regulation of astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle hypertrophy TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tyrosine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vascular endothelial growth factor production TAS
Traceable Author Statement
more info
PubMed 
regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
response to cytokine IDA
Inferred from Direct Assay
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
ciliary neurotrophic factor receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ciliary neurotrophic factor receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
interleukin-6 receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-6 receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
oncostatin-M receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oncostatin-M receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-6 receptor subunit beta
Names
CD130 antigen
IL-6 receptor subunit beta
IL-6R subunit beta
gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form
gp130, oncostatin M receptor
interleukin receptor beta chain
membrane glycoprotein 130
membrane glycoprotein gp130
oncostatin-M receptor subunit alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190981.1NP_001177910.1  interleukin-6 receptor subunit beta isoform 3 precursor

    See identical proteins and their annotated locations for NP_001177910.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AB102802, AC008914, AC016596, BQ013034, DA863210, DA877322
    Consensus CDS
    CCDS54856.1
    UniProtKB/Swiss-Prot
    P40189
    UniProtKB/TrEMBL
    A0A0A0N0L2
    Related
    ENSP00000370694.3, ENST00000381294.7
    Conserved Domains (4) summary
    smart00060
    Location:458538
    FN3; Fibronectin type 3 domain
    cd00063
    Location:222321
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26112
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:121215
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_001364275.1NP_001351204.1  interleukin-6 receptor subunit beta isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC008914, AC016596, HQ628629
    Conserved Domains (4) summary
    smart00060
    Location:485565
    FN3; Fibronectin type 3 domain
    cd00063
    Location:222321
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26112
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:121215
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. NM_001364276.1NP_001351205.1  interleukin-6 receptor subunit beta isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC008914, AC016596
    Conserved Domains (4) summary
    smart00060
    Location:449529
    FN3; Fibronectin type 3 domain
    cd00063
    Location:152251
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:2653
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:54145
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  4. NM_001364277.1NP_001351206.1  interleukin-6 receptor subunit beta isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC008914, AC016596
    Conserved Domains (1) summary
    smart00060
    Location:230310
    FN3; Fibronectin type 3 domain
  5. NM_001364278.1NP_001351207.1  interleukin-6 receptor subunit beta isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC008914, AC016596
    Conserved Domains (1) summary
    smart00060
    Location:218298
    FN3; Fibronectin type 3 domain
  6. NM_001364279.1NP_001351208.1  interleukin-6 receptor subunit beta isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC008914, AC016596
    Conserved Domains (1) summary
    smart00060
    Location:187267
    FN3; Fibronectin type 3 domain
  7. NM_002184.4NP_002175.2  interleukin-6 receptor subunit beta isoform 1 precursor

    See identical proteins and their annotated locations for NP_002175.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC008914, AC016596, BC117402, BQ013034, DA863210, M57230
    Consensus CDS
    CCDS3971.1
    UniProtKB/Swiss-Prot
    P40189
    UniProtKB/TrEMBL
    Q17RA0
    Related
    ENSP00000370698.2, ENST00000381298.6
    Conserved Domains (4) summary
    smart00060
    Location:519599
    FN3; Fibronectin type 3 domain
    cd00063
    Location:222321
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26112
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:121215
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  8. NM_175767.2NP_786943.1  interleukin-6 receptor subunit beta isoform 2 precursor

    See identical proteins and their annotated locations for NP_786943.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, which results in a frameshift in the 3' coding region and a premature termination codon, compared to variant 1. The resulting isoform (2, also known as gp130-RAPS) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AB015706, AB102802, AC008914, AC016596, BQ013034, DA863210, DA877322
    Consensus CDS
    CCDS47209.1
    UniProtKB/Swiss-Prot
    P40189
    Related
    ENSP00000370687.4, ENST00000381287.8
    Conserved Domains (3) summary
    cd00063
    Location:222321
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26112
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:121215
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. NR_120480.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an additional internal exon, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translation start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC008914, AC016596, BC143842, BQ013034, DA863210, M57230
  2. NR_157112.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008914, AC016596

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    55935095..55994993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009442.2XP_016864931.1  interleukin-6 receptor subunit beta isoform X2

    Conserved Domains (1) summary
    smart00060
    Location:218298
    FN3; Fibronectin type 3 domain
  2. XM_017009441.1XP_016864930.1  interleukin-6 receptor subunit beta isoform X1

    Conserved Domains (1) summary
    smart00060
    Location:230310
    FN3; Fibronectin type 3 domain

RNA

  1. XR_001742062.1 RNA Sequence

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