IL6ST interleukin 6 signal transducer [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL6STprovided by HGNC
Official Full Name: interleukin 6 signal transducerprovided by HGNC
Primary source: HGNC:HGNC:6021
See related: Ensembl:ENSG00000134352 MIM:600694; Vega:OTTHUMG00000097043
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD130; GP130; CDW130; IL-6RB
Summary: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
Expression: Ubiquitous expression in placenta (RPKM 88.6), fat (RPKM 53.5) and 24 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 5q11.2

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	5	NC_000005.10 (55935095..55994993, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (55230923..55290821, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Low soluble glycoprotein 130 (sgp130) level may serve as an additional indicator of coronary atherosclerosis severity.
Title: Soluble glycoprotein 130 is inversely related to severity of coronary atherosclerosis.
we show by molecular replacement that Arg-112 does not participate in binding of IL-11 to its receptors IL-11R and glycoprotein 130 (gp130). Recombinant IL-11 R112H expressed in E. coli displays a correct four-helix-bundle folding topology, and binds with similar affinity to IL-11R and the IL-11/IL-11R/gp130 complex.
Title: The SNP rs4252548 (R112H) which is associated with reduced human height compromises the stability of IL-11.
SNP rs10940495 in the gp130 locus was associated with functional outcome at 6 months following spontaneous intracerebral hemorrhage.
Title: Association of IL6ST (gp130) Polymorphism with Functional Outcome Following Spontaneous Intracerebral Hemorrhage.
Low levels of serum sgp130 were positively associated with sex hormones in male patients with coronary artery disease, suggesting an important role of sgp130 in the presence of low and imbalanced sex hormones levels.
Title: Circulating levels of sgp130 and sex hormones in male patients with coronary atherosclerotic disease.
Decreased serum LIF levels may be associated with vasculopathy in systemic sclerosis (SSc) and that Fli1 deficiency may contribute to the inhibition of LIF-dependent biological effects on SSc endothelial cells by suppressing the expression of LIF, LIF receptor, and gp130.
Title: A possible implication of reduced levels of LIF, LIFR, and gp130 in vasculopathy related to systemic sclerosis.
gp130 is associated with adverse postoperative clinical outcomes of patients with late-stage non-metastatic gastric cancer.
Title: Glycoprotein 130 is associated with adverse postoperative clinical outcomes of patients with late-stage non-metastatic gastric cancer.
GP130 signaling is required for tumor cell survival in diverse forms of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations.
Title: Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations.
Data show that tumor suppressor adenomatous polyposis coli (APC) loss results in up-regulation of IL-6 signal transducer (IL-6ST/gp130), thereby activating YAP (YY1-associated) protein (YAP) which are simultaneously up-regulated in the majority of colorectal cancer (CRC).
Title: YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.
study focused on IL-6 and activation of its receptors gp80 and gp130 in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet Kit, Unifast, and Duralay on control of inflammation
Title: Polyacrylic resins regulate transcriptional control of interleukin-6, gp80, and gp130 genes in human gingival fibroblasts.
an impaired oxidative stress response in hepatocytes with gp130 gain-of-function mutations, as detected in dysplastic intrahepatic nodules and hepatocellular adenomas, is one of the central oncogenic mechanisms in chronic liver inflammation.
Title: Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response.

Submit: New GeneRIF Correction See all GeneRIFs (158)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction	Pubs
Knockdown of interleukin 6 signal transducer (IL6ST; gp130, oncostatin M receptor; CD130) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	HIV-1 Nef downregulates the cell surface expression of interleukin 6 signal transducer (IL6ST, CD130)	PubMed
Tat	tat	HIV-1 Tat upregulates the expression of interleukin 6 signal transducer gene (IL6ST; GP130) in mammary epithelial cells	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Go to the top of the page Help

Adipogenesis, organism-specific biosystem (from WikiPathways)
Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
IL-6 signaling pathway, organism-specific biosystem (from WikiPathways)
IL-6 signaling pathway, organism-specific biosystemIL-6 is a pleiotropic cytokine with important role in immune regulation, hematopoiesis, inflammation and oncogenesis. IL-6-type cytokines exert their action via the signal transducer gp130 that assoc...
IL-6-type cytokine receptor ligand interactions, organism-specific biosystem (from REACTOME)
IL-6-type cytokine receptor ligand interactions, organism-specific biosystemThe members involved in (interleukin)-6-type cytokine signalling are the IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncostatin M), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CTF1)...
IL27-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
IL27-mediated signaling events, organism-specific biosystem
IL27-mediated signaling events
IL6-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
IL6-mediated signaling events, organism-specific biosystem
IL6-mediated signaling events
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Interleukin-11 Signaling Pathway, organism-specific biosystem (from WikiPathways)
Interleukin-11 Signaling Pathway, organism-specific biosystemIL-11 is a multifunctional cytokine that belongs to the gp130 family. It was first isolated from a primate bone marrow derived cell line, PU-34 for its ability to stimulate the proliferation of a pla...
Interleukin-6 family signaling, organism-specific biosystem (from REACTOME)
Interleukin-6 family signaling, organism-specific biosystemThe interleukin (IL)-6 family of cytokines is defined by the shared use of the common signal transducing receptor gp130 beta-subunit. This family includes structurally and functionally related IL-6, ...
Interleukin-6 signaling, organism-specific biosystem (from REACTOME)
Interleukin-6 signaling, organism-specific biosystemInterleukin-6 (IL-6) is a pleiotropic cytokine with roles in processes including immune regulation, hematopoiesis, inflammation, oncogenesis, metabolic control and sleep. It is the founding member o...
Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Jak-STAT signaling pathway, conserved biosystem (from KEGG)
Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
MAPK1 (ERK2) activation, organism-specific biosystem (from REACTOME)
MAPK1 (ERK2) activation, organism-specific biosystemMitogen-activated protein kinase kinase MAP2K2 (also known as MEK2) is a dual threonine and tyrosine recognition kinase that phosphorylates and activates MAPK1 (ERK2) (Ohren et al. 2004; Roskoski 201...
MAPK1/MAPK3 signaling, organism-specific biosystem (from REACTOME)
MAPK1/MAPK3 signaling, organism-specific biosystemThe extracellular signal regulated kinases (ERKs) 1 and 2, also known as MAPK3 and MAPK1, are phosphorylated by the MAP2Ks 1 and 2 in response to a wide range of extracellular stimuli to promote diff...
MAPK3 (ERK1) activation, organism-specific biosystem (from REACTOME)
MAPK3 (ERK1) activation, organism-specific biosystemMitogen-activated protein kinase kinase MAP2K1 (also known as MEK1) is a dual threonine and tyrosine recognition kinase that phosphorylates and activates MAPK3 (ERK1) (Ohren et al. 2004; Roskoski 201...
MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
Oncostatin M Signaling Pathway, organism-specific biosystem (from WikiPathways)
Oncostatin M Signaling Pathway, organism-specific biosystemOncostatin M (OSM) is a member of the multifunctional cytokine interleukin 6 (IL6) - type cytokine family. It is mainly produced in cell types such as activated T lymphocytes, macrophages, monocytes,...
Physiological and Pathological Hypertrophy of the Heart, organism-specific biosystem (from WikiPathways)
Physiological and Pathological Hypertrophy of the Heart, organism-specific biosystemPathways in physiological and pathological hypertrophy of the heart. Largely based on the article from Wang Y; ''Signal transduction in cardiac hypertrophy--dissecting compensatory versus pathologica...
RAF-independent MAPK1/3 activation, organism-specific biosystem (from REACTOME)
RAF-independent MAPK1/3 activation, organism-specific biosystemDepending upon the stimulus and cell type mitogen-activated protein kinases (MAPK) signaling pathway can transmit signals to regulate many different biological processes by virtue of their ability to...
Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by Interleukins, organism-specific biosystem (from REACTOME)
Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
Th17 cell differentiation, organism-specific biosystem (from KEGG)
Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
Th17 cell differentiation, conserved biosystem (from KEGG)
Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
Viral carcinogenesis, organism-specific biosystem (from KEGG)
Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Viral carcinogenesis, conserved biosystem (from KEGG)
Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH15643 (e-PCR)
- UniSTS:61441

D5S2597 (e-PCR)
- UniSTS:63500

G24196 (e-PCR)
- UniSTS:81178

GDB:353575 (e-PCR)
- UniSTS:156705

GDB:353576 (e-PCR)
- UniSTS:156706

SHGC-58193 (e-PCR)
- UniSTS:78730

RH15655 (e-PCR)
- UniSTS:56459

GDB:592062 (e-PCR)
- UniSTS:157899

IL6ST_1708 (e-PCR)
- UniSTS:280786

RH17700 (e-PCR)
- UniSTS:4833

D17S58 (e-PCR)
- UniSTS:153826

Homology

Homologs of the IL6ST gene: The IL6ST gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 226 organisms have orthologs with human gene IL6ST
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ciliary neurotrophic factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
ciliary neurotrophic factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
ciliary neurotrophic factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
cytokine binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
interleukin-11 binding	IEA Inferred from Electronic Annotation more info
interleukin-11 receptor activity	IEA Inferred from Electronic Annotation more info
interleukin-27 receptor activity	IC Inferred by Curator more info	PubMed
contributes_to interleukin-6 binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to interleukin-6 binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to interleukin-6 receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to interleukin-6 receptor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to interleukin-6 receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to interleukin-6 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to leukemia inhibitory factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to leukemia inhibitory factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to oncostatin-M receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to oncostatin-M receptor activity	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
ciliary neurotrophic factor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
glycogen metabolic process	IEA Inferred from Electronic Annotation more info
interleukin-11-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
interleukin-27-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
interleukin-27-mediated signaling pathway	TAS Traceable Author Statement more info
interleukin-35-mediated signaling pathway	TAS Traceable Author Statement more info
interleukin-6-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
interleukin-6-mediated signaling pathway	TAS Traceable Author Statement more info
leukemia inhibitory factor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
oncostatin-M-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of acute inflammatory response	IC Inferred by Curator more info	PubMed
positive regulation of adaptive immune response	IC Inferred by Curator more info	PubMed
positive regulation of astrocyte differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of cardiac muscle hypertrophy	TAS Traceable Author Statement more info	PubMed
positive regulation of cell proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of tyrosine phosphorylation of STAT protein	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of tyrosine phosphorylation of STAT protein	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of vascular endothelial growth factor production	TAS Traceable Author Statement more info	PubMed
regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
response to cytokine	IDA Inferred from Direct Assay more info	PubMed
viral process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
ciliary neurotrophic factor receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
ciliary neurotrophic factor receptor complex	IDA Inferred from Direct Assay more info	PubMed
dendrite	IEA Inferred from Electronic Annotation more info
external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
extracellular exosome	HDA more info	PubMed
extracellular region	TAS Traceable Author Statement more info
interleukin-6 receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
interleukin-6 receptor complex	IDA Inferred from Direct Assay more info	PubMed
membrane	HDA more info	PubMed
neuronal cell body	IEA Inferred from Electronic Annotation more info
oncostatin-M receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
oncostatin-M receptor complex	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info
receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: interleukin-6 receptor subunit beta

Names: CD130 antigen; IL-6 receptor subunit beta; IL-6R subunit beta; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130, oncostatin M receptor; interleukin receptor beta chain; membrane glycoprotein 130; membrane glycoprotein gp130; oncostatin-M receptor subunit alpha

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190981.1 → NP_001177910.1 interleukin-6 receptor subunit beta isoform 3 precursor

See identical proteins and their annotated locations for NP_001177910.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.

Source sequence(s)

AB102802, AC008914, AC016596, BQ013034, DA863210, DA877322

Consensus CDS

CCDS54856.1

UniProtKB/Swiss-Prot

P40189

UniProtKB/TrEMBL

A0A0A0N0L2

Related

ENSP00000370694.3, OTTHUMP00000260242, ENST00000381294.7, OTTHUMT00000443710

Conserved Domains (4) summary

smart00060
Location:458 → 538

FN3; Fibronectin type 3 domain

cd00063
Location:222 → 321

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:26 → 112

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:121 → 215

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001364275.1 → NP_001351204.1 interleukin-6 receptor subunit beta isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AC008914, AC016596, HQ628629

Conserved Domains (4) summary

smart00060
Location:485 → 565

FN3; Fibronectin type 3 domain

cd00063
Location:222 → 321

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:26 → 112

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:121 → 215

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001364276.1 → NP_001351205.1 interleukin-6 receptor subunit beta isoform 5 precursor

Status: REVIEWED

Source sequence(s)

AC008914, AC016596

Conserved Domains (4) summary

smart00060
Location:449 → 529

FN3; Fibronectin type 3 domain

cd00063
Location:152 → 251

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:26 → 53

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:54 → 145

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001364277.1 → NP_001351206.1 interleukin-6 receptor subunit beta isoform 6

Status: REVIEWED

Source sequence(s)

AC008914, AC016596

Conserved Domains (1) summary

smart00060
Location:230 → 310

FN3; Fibronectin type 3 domain
NM_001364278.1 → NP_001351207.1 interleukin-6 receptor subunit beta isoform 7

Status: REVIEWED

Source sequence(s)

AC008914, AC016596

Conserved Domains (1) summary

smart00060
Location:218 → 298

FN3; Fibronectin type 3 domain
NM_001364279.1 → NP_001351208.1 interleukin-6 receptor subunit beta isoform 8

Status: REVIEWED

Source sequence(s)

AC008914, AC016596

Conserved Domains (1) summary

smart00060
Location:187 → 267

FN3; Fibronectin type 3 domain
NM_002184.3 → NP_002175.2 interleukin-6 receptor subunit beta isoform 1 precursor

See identical proteins and their annotated locations for NP_002175.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC008914, AC016596, BC117402, BQ013034, DA863210, M57230

Consensus CDS

CCDS3971.1

UniProtKB/Swiss-Prot

P40189

UniProtKB/TrEMBL

Q17RA0

Related

ENSP00000370698.2, OTTHUMP00000122545, ENST00000381298.6, OTTHUMT00000214146

Conserved Domains (4) summary

smart00060
Location:519 → 599

FN3; Fibronectin type 3 domain

cd00063
Location:222 → 321

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:26 → 112

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:121 → 215

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_175767.2 → NP_786943.1 interleukin-6 receptor subunit beta isoform 2 precursor

See identical proteins and their annotated locations for NP_786943.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate internal exon, which results in a frameshift in the 3' coding region and a premature termination codon, compared to variant 1. The resulting isoform (2, also known as gp130-RAPS) has a distinct and shorter C-terminus, compared to isoform 1.

Source sequence(s)

AB015706, AB102802, AC008914, AC016596, BQ013034, DA863210, DA877322

Consensus CDS

CCDS47209.1

UniProtKB/Swiss-Prot

P40189

Related

ENSP00000370687.4, ENST00000381287.8

Conserved Domains (3) summary

cd00063
Location:222 → 321

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:26 → 112

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:121 → 215

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

NR_120480.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) has an additional internal exon, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translation start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC008914, AC016596, BC143842, BQ013034, DA863210, M57230
NR_157112.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC008914, AC016596

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p12 Primary Assembly

Range

55935095..55994993 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017009442.2 → XP_016864931.1 interleukin-6 receptor subunit beta isoform X2

Conserved Domains (1) summary

smart00060
Location:218 → 298

FN3; Fibronectin type 3 domain
XM_017009441.1 → XP_016864930.1 interleukin-6 receptor subunit beta isoform X1

Conserved Domains (1) summary

smart00060
Location:230 → 310

FN3; Fibronectin type 3 domain