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IL6ST interleukin 6 signal transducer [ Homo sapiens (human) ]

Gene ID: 3572, updated on 24-Nov-2020

Summary

Official Symbol
IL6STprovided by HGNC
Official Full Name
interleukin 6 signal transducerprovided by HGNC
Primary source
HGNC:HGNC:6021
See related
Ensembl:ENSG00000134352 MIM:600694
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD130; GP130; HIES4; CDW130; IL-6RB; sGP130
Summary
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in placenta (RPKM 88.6), fat (RPKM 53.5) and 24 other tissues See more
Orthologs

Genomic context

See IL6ST in Genome Data Viewer
Location:
5q11.2
Exon count:
19
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (55935095..55994963, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (55230923..55290821, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein H1 pseudogene 3 Neighboring gene interleukin 31 receptor A Neighboring gene Sharpr-MPRA regulatory region 5314 Neighboring gene uncharacterized LOC441072 Neighboring gene uncharacterized LOC105378976 Neighboring gene ankyrin repeat domain 55

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
HYPER-IgE RECURRENT INFECTION SYNDROME 4, AUTOSOMAL RECESSIVE
MedGen: C5193141 OMIM: 618523 GeneReviews: Not available
not available
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of interleukin 6 signal transducer (IL6ST; gp130, oncostatin M receptor; CD130) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef downregulates the cell surface expression of interleukin 6 signal transducer (IL6ST, CD130) PubMed
Tat tat HIV-1 Tat upregulates the expression of interleukin 6 signal transducer gene (IL6ST; GP130) in mammary epithelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564F053

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ciliary neurotrophic factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
ciliary neurotrophic factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
interleukin-11 binding IEA
Inferred from Electronic Annotation
more info
 
interleukin-11 receptor activity IEA
Inferred from Electronic Annotation
more info
 
interleukin-27 receptor activity IC
Inferred by Curator
more info
PubMed 
contributes_to interleukin-6 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to interleukin-6 binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to interleukin-6 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to interleukin-6 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to interleukin-6 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to leukemia inhibitory factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to oncostatin-M receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ciliary neurotrophic factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
interleukin-11-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
interleukin-27-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-27-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-35-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-6-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-6-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-6-mediated signaling pathway TAS
Traceable Author Statement
more info
 
intestinal epithelial cell development IDA
Inferred from Direct Assay
more info
PubMed 
leukemia inhibitory factor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
oncostatin-M-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of acute inflammatory response IC
Inferred by Curator
more info
PubMed 
positive regulation of adaptive immune response IC
Inferred by Curator
more info
PubMed 
positive regulation of astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle hypertrophy TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vascular endothelial growth factor production TAS
Traceable Author Statement
more info
PubMed 
response to cytokine IDA
Inferred from Direct Assay
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
ciliary neurotrophic factor receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
interleukin-6 receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
oncostatin-M receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-6 receptor subunit beta
Names
CD130 antigen
IL-6 receptor subunit beta
IL-6R subunit beta
gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form
gp130, oncostatin M receptor
interleukin receptor beta chain
membrane glycoprotein 130
membrane glycoprotein gp130
oncostatin-M receptor subunit alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190981.2NP_001177910.1  interleukin-6 receptor subunit beta isoform 3 precursor

    See identical proteins and their annotated locations for NP_001177910.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AB102802, AC008914, AC016596, BQ013034, DA863210, DA877322
    Consensus CDS
    CCDS54856.1
    UniProtKB/Swiss-Prot
    P40189
    UniProtKB/TrEMBL
    A0A0A0N0L2
    Related
    ENSP00000370694.3, ENST00000381294.7
    Conserved Domains (4) summary
    smart00060
    Location:458538
    FN3; Fibronectin type 3 domain
    cd00063
    Location:222321
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26112
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:121215
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_001364275.2NP_001351204.1  interleukin-6 receptor subunit beta isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC008914, AC016596, HQ628629
    Conserved Domains (4) summary
    smart00060
    Location:485565
    FN3; Fibronectin type 3 domain
    cd00063
    Location:222321
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26112
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:121215
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. NM_001364276.2NP_001351205.1  interleukin-6 receptor subunit beta isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC008914, AC016596
    Conserved Domains (4) summary
    smart00060
    Location:449529
    FN3; Fibronectin type 3 domain
    cd00063
    Location:152251
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:2653
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:54145
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  4. NM_001364277.2NP_001351206.1  interleukin-6 receptor subunit beta isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC008914, AC016596
    Conserved Domains (1) summary
    smart00060
    Location:230310
    FN3; Fibronectin type 3 domain
  5. NM_001364278.2NP_001351207.1  interleukin-6 receptor subunit beta isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC008914, AC016596
    Conserved Domains (1) summary
    smart00060
    Location:218298
    FN3; Fibronectin type 3 domain
  6. NM_001364279.2NP_001351208.1  interleukin-6 receptor subunit beta isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC008914, AC016596
    Conserved Domains (1) summary
    smart00060
    Location:187267
    FN3; Fibronectin type 3 domain
  7. NM_002184.4NP_002175.2  interleukin-6 receptor subunit beta isoform 1 precursor

    See identical proteins and their annotated locations for NP_002175.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC008914, AC016596, BC117402, BQ013034, DA863210, M57230
    Consensus CDS
    CCDS3971.1
    UniProtKB/Swiss-Prot
    P40189
    UniProtKB/TrEMBL
    Q17RA0
    Related
    ENSP00000370698.2, ENST00000381298.7
    Conserved Domains (4) summary
    smart00060
    Location:519599
    FN3; Fibronectin type 3 domain
    cd00063
    Location:222321
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26112
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:121215
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  8. NM_175767.3NP_786943.1  interleukin-6 receptor subunit beta isoform 2 precursor

    See identical proteins and their annotated locations for NP_786943.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, which results in a frameshift in the 3' coding region and a premature termination codon, compared to variant 1. The resulting isoform (2, also known as gp130-RAPS) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AB015706, AB102802, AC008914, AC016596, BQ013034, DA863210, DA877322
    Consensus CDS
    CCDS47209.1
    UniProtKB/Swiss-Prot
    P40189
    Related
    ENSP00000370687.4, ENST00000381287.8
    Conserved Domains (3) summary
    cd00063
    Location:222321
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26112
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:121215
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. NR_120480.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an additional internal exon, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translation start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC008914, AC016596, BC143842, BQ013034, DA863210, M57230
  2. NR_157112.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008914, AC016596
    Related
    ENST00000651614.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    55935095..55994963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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