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DGKB diacylglycerol kinase beta [ Homo sapiens (human) ]

Gene ID: 1607, updated on 8-Dec-2018

Summary

Official Symbol
DGKBprovided by HGNC
Official Full Name
diacylglycerol kinase betaprovided by HGNC
Primary source
HGNC:HGNC:2850
See related
Ensembl:ENSG00000136267 MIM:604070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DGK; DAGK2; DGK-BETA
Summary
Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
Expression
Biased expression in brain (RPKM 7.2), adrenal (RPKM 0.9) and 2 other tissues See more
Orthologs

Genomic context

See DGKB in Genome Data Viewer
Location:
7p21.2
Exon count:
32
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (14145049..14974777, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (14184674..14943281, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375162 Neighboring gene solute carrier family 34 member 2 pseudogene Neighboring gene ribosomal protein L6 pseudogene 21 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 26 Neighboring gene VISTA enhancer hs816 Neighboring gene uncharacterized LOC105375164 Neighboring gene general transcription factor IIIA pseudogene 5 Neighboring gene alkylglycerol monooxygenase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
NHGRI GWA Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
NHGRI GWA Catalog
Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.
NHGRI GWA Catalog
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
NHGRI GWA Catalog
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
NHGRI GWA Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
NHGRI GWA Catalog
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0718

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NAD+ kinase activity IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
diacylglycerol kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerolipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerolipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
lipid phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
protein kinase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of postsynapse organization IEA
Inferred from Electronic Annotation
more info
 
response to bacterium IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
diacylglycerol kinase beta
Names
90 kDa diacylglycerol kinase
DAG kinase beta
diacylglycerol kinase, beta 90kDa
diglyceride kinase beta
NP_001337634.1
NP_001337635.1
NP_001337636.1
NP_001337637.1
NP_001337638.1
NP_001337640.1
NP_001337641.1
NP_001337643.1
NP_001337644.1
NP_001337645.1
NP_001337646.1
NP_001337647.1
NP_001337648.1
NP_001337649.1
NP_001337650.1
NP_001337651.1
NP_001337652.1
NP_001337653.1
NP_663733.1
XP_011513456.1
XP_016867279.1
XP_016867280.1
XP_016867281.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029494.2 RefSeqGene

    Range
    76122..834729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001350705.1NP_001337634.1  diacylglycerol kinase beta isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Consensus CDS
    CCDS47547.1
    Related
    ENSP00000385780.2, ENST00000403951.6
    Conserved Domains (6) summary
    smart00045
    Location:582762
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:440561
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310361
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7149
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  2. NM_001350706.1NP_001337635.1  diacylglycerol kinase beta isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Consensus CDS
    CCDS47547.1
    Related
    ENSP00000382260.3, ENST00000399322.7
    Conserved Domains (6) summary
    smart00045
    Location:582762
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:440561
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310361
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7149
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  3. NM_001350707.1NP_001337636.1  diacylglycerol kinase beta isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform 3.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Consensus CDS
    CCDS87481.1
    Conserved Domains (6) summary
    smart00045
    Location:581761
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:439560
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310361
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7149
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  4. NM_001350708.1NP_001337637.1  diacylglycerol kinase beta isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform 3.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Consensus CDS
    CCDS87481.1
    Conserved Domains (6) summary
    smart00045
    Location:581761
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:439560
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310361
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7149
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  5. NM_001350709.1NP_001337638.1  diacylglycerol kinase beta isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform 3.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Consensus CDS
    CCDS87481.1
    Related
    ENSP00000384909.1, ENST00000402815.5
    Conserved Domains (6) summary
    smart00045
    Location:581761
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:439560
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310361
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7149
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  6. NM_001350711.1NP_001337640.1  diacylglycerol kinase beta isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 8 and 9, encodes isoform 4.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Consensus CDS
    CCDS87480.1
    Conserved Domains (6) summary
    smart00045
    Location:574754
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:432553
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:238287
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:146215
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:303354
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7142
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  7. NM_001350712.1NP_001337641.1  diacylglycerol kinase beta isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 7 and 9, encodes isoform 4.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Consensus CDS
    CCDS87480.1
    Conserved Domains (6) summary
    smart00045
    Location:574754
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:432553
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:238287
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:146215
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:303354
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7142
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  8. NM_001350714.1NP_001337643.1  diacylglycerol kinase beta isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 7 and 8, encodes isoform 4.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Consensus CDS
    CCDS87480.1
    Related
    ENSP00000385031.1, ENST00000407950.5
    Conserved Domains (6) summary
    smart00045
    Location:574754
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:432553
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:238287
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:146215
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:303354
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7142
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  9. NM_001350715.1NP_001337644.1  diacylglycerol kinase beta isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variant 11, encodes isoform 5.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Conserved Domains (6) summary
    smart00045
    Location:575755
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:433554
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:238287
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:146215
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:303354
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7142
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  10. NM_001350716.1NP_001337645.1  diacylglycerol kinase beta isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variant 10, encodes isoform 5.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Conserved Domains (6) summary
    smart00045
    Location:575755
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:433554
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:238287
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:146215
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:303354
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7142
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  11. NM_001350717.1NP_001337646.1  diacylglycerol kinase beta isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform 6.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Conserved Domains (6) summary
    smart00045
    Location:570750
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:428549
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310361
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7149
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  12. NM_001350718.1NP_001337647.1  diacylglycerol kinase beta isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform 6.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Conserved Domains (6) summary
    smart00045
    Location:570750
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:428549
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310361
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7149
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  13. NM_001350719.1NP_001337648.1  diacylglycerol kinase beta isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform 6.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Conserved Domains (6) summary
    smart00045
    Location:570750
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:428549
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310361
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7149
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  14. NM_001350720.1NP_001337649.1  diacylglycerol kinase beta isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variant 16, encodes isoform 7.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Conserved Domains (6) summary
    smart00045
    Location:563743
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:421542
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:238287
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:146215
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:303354
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7142
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  15. NM_001350721.1NP_001337650.1  diacylglycerol kinase beta isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 15, encodes isoform 7.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Conserved Domains (6) summary
    smart00045
    Location:563743
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:421542
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:238287
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:146215
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:303354
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7142
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  16. NM_001350722.1NP_001337651.1  diacylglycerol kinase beta isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 18, encodes isoform 8.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Conserved Domains (6) summary
    smart00045
    Location:540720
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:398519
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:203252
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:111180
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:268319
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:14107
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  17. NM_001350723.1NP_001337652.1  diacylglycerol kinase beta isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variant 17, encodes isoform 8.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Conserved Domains (6) summary
    smart00045
    Location:540720
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:398519
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:203252
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:111180
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:268319
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:14107
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  18. NM_001350724.1NP_001337653.1  diacylglycerol kinase beta isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) encodes isoform 9.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Conserved Domains (6) summary
    smart00045
    Location:532712
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:390511
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:196245
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:104173
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:261312
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7100
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  19. NM_145695.2NP_663733.1  diacylglycerol kinase beta isoform 2

    See identical proteins and their annotated locations for NP_663733.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a distinct 3' UTR and 3' coding region compared to variant (1). The encoded protein (2) has a shorter, alternate C-terminus compared to isoform (1).
    Source sequence(s)
    AC005039, BC105005, DA321150
    Consensus CDS
    CCDS47548.1
    UniProtKB/Swiss-Prot
    Q9Y6T7
    Related
    ENSP00000386066.3, ENST00000406247.7
    Conserved Domains (8) summary
    smart00045
    Location:582762
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:440561
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:440772
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00029
    Location:245294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310361
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:154218
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:6149
    DAG_kinase_N; Diacylglycerol kinase N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    14145049..14974777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515154.2XP_011513456.1  diacylglycerol kinase beta isoform X1

    See identical proteins and their annotated locations for XP_011513456.1

    UniProtKB/Swiss-Prot
    Q9Y6T7
    Conserved Domains (6) summary
    smart00045
    Location:582762
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:440561
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310361
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7149
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  2. XM_017011790.1XP_016867279.1  diacylglycerol kinase beta isoform X2

    Conserved Domains (7) summary
    smart00046
    Location:440561
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310361
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:154218
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:6149
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cl02440
    Location:582679
    DAGK_acc; Diacylglycerol kinase accessory domain
  3. XM_017011791.1XP_016867280.1  diacylglycerol kinase beta isoform X3

  4. XM_017011792.2XP_016867281.1  diacylglycerol kinase beta isoform X4

RNA

  1. XR_001744571.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004080.2: Suppressed sequence

    Description
    NM_004080.2: This RefSeq was removed because currently there is insufficient support for the 5' end of the transcript.
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