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DAD1 defender against cell death 1 [ Homo sapiens (human) ]

Gene ID: 1603, updated on 5-Jan-2020

Summary

Official Symbol
DAD1provided by HGNC
Official Full Name
defender against cell death 1provided by HGNC
Primary source
HGNC:HGNC:2664
See related
Ensembl:ENSG00000129562 MIM:600243
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OST2
Summary
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 108.7), adrenal (RPKM 94.4) and 25 other tissues See more
Orthologs

Genomic context

See DAD1 in Genome Data Viewer
Location:
14q11.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (22564907..22589224, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23033807..23058143, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene T cell receptor alpha locus Neighboring gene uncharacterized LOC105370399 Neighboring gene long intergenic non-protein coding RNA 2332 Neighboring gene T cell receptor alpha constant Neighboring gene abhydrolase domain containing 4, N-acyl phospholipase B Neighboring gene olfactory receptor family 6 subfamily J member 1 (gene/pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of defender against cell death 1 (DAD1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
blastocyst development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein N-linked glycosylation via asparagine IC
Inferred by Curator
more info
PubMed 
protein N-linked glycosylation via asparagine TAS
Traceable Author Statement
more info
 
protein glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to nutrient IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oligosaccharyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
oligosaccharyltransferase complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
Names
DAD-1
oligosaccharyl transferase subunit DAD1
oligosaccharyltransferase 2 homolog
oligosaccharyltransferase subunit 2 (non-catalytic)
NP_001335.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001344.4NP_001335.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

    See identical proteins and their annotated locations for NP_001335.1

    Status: REVIEWED

    Source sequence(s)
    AC243965, AK223129, BP198316
    Consensus CDS
    CCDS9571.1
    UniProtKB/Swiss-Prot
    P61803
    UniProtKB/TrEMBL
    Q53G02
    Related
    ENSP00000250498.4, ENST00000250498.9
    Conserved Domains (1) summary
    pfam02109
    Location:7113
    DAD; DAD family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    22564907..22589224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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