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DAD1 defender against cell death 1 [ Homo sapiens (human) ]

Gene ID: 1603, updated on 27-Nov-2024

Summary

Official Symbol
DAD1provided by HGNC
Official Full Name
defender against cell death 1provided by HGNC
Primary source
HGNC:HGNC:2664
See related
Ensembl:ENSG00000129562 MIM:600243; AllianceGenome:HGNC:2664
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OST2
Summary
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 108.7), adrenal (RPKM 94.4) and 25 other tissues See more
Orthologs
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Genomic context

See DAD1 in Genome Data Viewer
Location:
14q11.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (22564907..22589224, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (16762628..16786951, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23033807..23058130, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene T cell receptor alpha locus Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8130 Neighboring gene uncharacterized LOC105370399 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8135 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:23039191-23039913 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:23049159-23049321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23051199-23051700 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:23057127-23057768 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:23057769-23058410 Neighboring gene long intergenic non-protein coding RNA 2332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5587 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:23105272-23105983 Neighboring gene T cell receptor alpha constant Neighboring gene abhydrolase domain containing 4, N-acyl phospholipase B Neighboring gene olfactory receptor family 6 subfamily J member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of defender against cell death 1 (DAD1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in blastocyst development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein N-linked glycosylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein N-linked glycosylation via asparagine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of oligosaccharyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of oligosaccharyltransferase complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of oligosaccharyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of oligosaccharyltransferase complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
Names
DAD-1
oligosaccharyl transferase subunit DAD1
oligosaccharyltransferase 2 homolog
oligosaccharyltransferase subunit 2 (non-catalytic)
NP_001335.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001344.4NP_001335.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

    See identical proteins and their annotated locations for NP_001335.1

    Status: REVIEWED

    Source sequence(s)
    AC243965, AK223129, BP198316
    Consensus CDS
    CCDS9571.1
    UniProtKB/Swiss-Prot
    D3DS25, O08552, O70364, P46966, P46968, P61803, Q6FGA3, Q96GB7
    UniProtKB/TrEMBL
    Q53G02
    Related
    ENSP00000250498.4, ENST00000250498.9
    Conserved Domains (1) summary
    pfam02109
    Location:7113
    DAD; DAD family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    22564907..22589224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    16762628..16786951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)